Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem

Handle URI:
http://hdl.handle.net/10754/623266
Title:
Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem
Authors:
Dippenaar, Anzaan; Parsons, Sven David Charles; Miller, Michele Ann; Hlokwe, Tiny; van Pittius, Nicolaas Claudius Gey; Adroub, Sabir Abdu; Abdallah, Abdallah Musa; Pain, Arnab ( 0000-0002-1755-2819 ) ; Warren, Robin Mark; Michel, Anita Luise; van Helden, Paul David
Abstract:
Mycobacterium bovis infects multiple wildlife species and domesticated cattle across South Africa, and negatively impacts on livestock trade and movement of wildlife for conservation purposes. M. bovis infection was first reported in the Kruger National Park (KNP) in South Africa during the 1990s, and has since spread to infect numerous animal host species throughout the park and across South Africa. Whole genome sequencing data of 17 M. bovis isolates were analyzed to investigate the genomic diversity among M. bovis isolates causing disease in different animal host species from various locations in South Africa. M. bovis strains analyzed in this study are geographic rather than host species-specific. The clonal expansion of M. bovis in the KNP highlights the effect of an introduction of a transmissible infectious disease leading to a rising epidemic in wildlife, and emphasizes the importance of disease control and movement restriction of species that serve as disease reservoirs. In conclusion, the point source introduction of a single M. bovis strain type in the KNP ecosystem lead to an M. bovis outbreak in this area that affects various host species and poses an infection risk in neighboring rural communities where HIV prevalence is high.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Pathogen Genomics Laboratory
Citation:
Dippenaar A, Parsons SDC, Miller MA, Hlokwe T, van Pittius NCG, et al. (2017) Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem. Infection, Genetics and Evolution. Available: http://dx.doi.org/10.1016/j.meegid.2017.04.012.
Publisher:
Elsevier BV
Journal:
Infection, Genetics and Evolution
Issue Date:
13-Apr-2017
DOI:
10.1016/j.meegid.2017.04.012
Type:
Article
ISSN:
1567-1348
Sponsors:
This study was enabled by funding from the South African Medical Research Council, the National Research Foundation, and faculty baseline funding from King Abdullah University of Science and Technology (KAUST, Thuwal, Saudi Arabia) awarded to A Pain. MA Miller is funded by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation (NRF) of South Africa, award number UID 86949. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard. The authors declare that no conflict of interest exists.
Additional Links:
http://www.sciencedirect.com/science/article/pii/S1567134817301259
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorDippenaar, Anzaanen
dc.contributor.authorParsons, Sven David Charlesen
dc.contributor.authorMiller, Michele Annen
dc.contributor.authorHlokwe, Tinyen
dc.contributor.authorvan Pittius, Nicolaas Claudius Geyen
dc.contributor.authorAdroub, Sabir Abduen
dc.contributor.authorAbdallah, Abdallah Musaen
dc.contributor.authorPain, Arnaben
dc.contributor.authorWarren, Robin Marken
dc.contributor.authorMichel, Anita Luiseen
dc.contributor.authorvan Helden, Paul Daviden
dc.date.accessioned2017-04-20T08:08:16Z-
dc.date.available2017-04-20T08:08:16Z-
dc.date.issued2017-04-13en
dc.identifier.citationDippenaar A, Parsons SDC, Miller MA, Hlokwe T, van Pittius NCG, et al. (2017) Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem. Infection, Genetics and Evolution. Available: http://dx.doi.org/10.1016/j.meegid.2017.04.012.en
dc.identifier.issn1567-1348en
dc.identifier.doi10.1016/j.meegid.2017.04.012en
dc.identifier.urihttp://hdl.handle.net/10754/623266-
dc.description.abstractMycobacterium bovis infects multiple wildlife species and domesticated cattle across South Africa, and negatively impacts on livestock trade and movement of wildlife for conservation purposes. M. bovis infection was first reported in the Kruger National Park (KNP) in South Africa during the 1990s, and has since spread to infect numerous animal host species throughout the park and across South Africa. Whole genome sequencing data of 17 M. bovis isolates were analyzed to investigate the genomic diversity among M. bovis isolates causing disease in different animal host species from various locations in South Africa. M. bovis strains analyzed in this study are geographic rather than host species-specific. The clonal expansion of M. bovis in the KNP highlights the effect of an introduction of a transmissible infectious disease leading to a rising epidemic in wildlife, and emphasizes the importance of disease control and movement restriction of species that serve as disease reservoirs. In conclusion, the point source introduction of a single M. bovis strain type in the KNP ecosystem lead to an M. bovis outbreak in this area that affects various host species and poses an infection risk in neighboring rural communities where HIV prevalence is high.en
dc.description.sponsorshipThis study was enabled by funding from the South African Medical Research Council, the National Research Foundation, and faculty baseline funding from King Abdullah University of Science and Technology (KAUST, Thuwal, Saudi Arabia) awarded to A Pain. MA Miller is funded by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation (NRF) of South Africa, award number UID 86949. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard. The authors declare that no conflict of interest exists.en
dc.publisherElsevier BVen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S1567134817301259en
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Infection, Genetics and Evolution. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Infection, Genetics and Evolution, 13 April 2017. DOI: 10.1016/j.meegid.2017.04.012. © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectKruger National parken
dc.subjectMycobacterium bovisen
dc.subjectWhole genome sequenceen
dc.subjectBovine tuberculosisen
dc.titleProgenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystemen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentPathogen Genomics Laboratoryen
dc.identifier.journalInfection, Genetics and Evolutionen
dc.eprint.versionPost-printen
dc.contributor.institutionDST/NRF Centre of Excellence in Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Francie van Zijl Drive, Cape Town 8000, South Africaen
dc.contributor.institutionTuberculosis Laboratory, ARC-Onderstepoort Veterinary Institute, South Africaen
dc.contributor.institutionDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africaen
kaust.authorAdroub, Sabir Abduen
kaust.authorAbdallah, Abdallah Musaen
kaust.authorPain, Arnaben
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