The Emerging Role of Epigenetics on Dietary Treatment for Epilepsy

Handle URI:
http://hdl.handle.net/10754/623188
Title:
The Emerging Role of Epigenetics on Dietary Treatment for Epilepsy
Authors:
Landgrave Gomez, Jorge; Vargas-Romero, Fernanda; Mercado-Gómez, Octavio Fabian; Guevara-Guzmán, Rosalinda
Abstract:
Purpose of ReviewSeizures are able to induce a wide range of complex alterations that may be due to abnormalities in gene expression patterns. In recent years, there has been resurgence regarding the use of dietary therapies for seizure treatment. Unfortunately, the precise mechanisms by which these therapies exert its effects remain unknown.Recent FindingsRecent evidence suggest that dietary treatment, throughout a metabolic shift, could impact the concentration of some metabolites, such as beta-hydroxybutyrate (B-HB) or S-adenosyl methionine (SAM), which are able to modulate the activity of enzymes involved in regulatory processes that control gene expression. Despite of this evidence, only a few studies have fully explored this emerging field.SummaryThe purpose of this article is to discuss how dietary treatment, throughout these molecules, could influence epigenetic modifications that may be able to restore aberrant patterns of gene expression produced by seizures, having an impact on this complex disease, such as seizures or even in epileptogenesis.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Landgrave-Gómez J, Vargas-Romero F, Mercado-Gómez OF, Guevara-Guzmán R (2017) The Emerging Role of Epigenetics on Dietary Treatment for Epilepsy. Current Nutrition Reports 6: 9–15. Available: http://dx.doi.org/10.1007/s13668-017-0189-7.
Publisher:
Springer Nature
Journal:
Current Nutrition Reports
Issue Date:
15-Feb-2017
DOI:
10.1007/s13668-017-0189-7
Type:
Article
ISSN:
2161-3311
Additional Links:
http://link.springer.com/article/10.1007/s13668-017-0189-7
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLandgrave Gomez, Jorgeen
dc.contributor.authorVargas-Romero, Fernandaen
dc.contributor.authorMercado-Gómez, Octavio Fabianen
dc.contributor.authorGuevara-Guzmán, Rosalindaen
dc.date.accessioned2017-04-13T11:51:00Z-
dc.date.available2017-04-13T11:51:00Z-
dc.date.issued2017-02-15en
dc.identifier.citationLandgrave-Gómez J, Vargas-Romero F, Mercado-Gómez OF, Guevara-Guzmán R (2017) The Emerging Role of Epigenetics on Dietary Treatment for Epilepsy. Current Nutrition Reports 6: 9–15. Available: http://dx.doi.org/10.1007/s13668-017-0189-7.en
dc.identifier.issn2161-3311en
dc.identifier.doi10.1007/s13668-017-0189-7en
dc.identifier.urihttp://hdl.handle.net/10754/623188-
dc.description.abstractPurpose of ReviewSeizures are able to induce a wide range of complex alterations that may be due to abnormalities in gene expression patterns. In recent years, there has been resurgence regarding the use of dietary therapies for seizure treatment. Unfortunately, the precise mechanisms by which these therapies exert its effects remain unknown.Recent FindingsRecent evidence suggest that dietary treatment, throughout a metabolic shift, could impact the concentration of some metabolites, such as beta-hydroxybutyrate (B-HB) or S-adenosyl methionine (SAM), which are able to modulate the activity of enzymes involved in regulatory processes that control gene expression. Despite of this evidence, only a few studies have fully explored this emerging field.SummaryThe purpose of this article is to discuss how dietary treatment, throughout these molecules, could influence epigenetic modifications that may be able to restore aberrant patterns of gene expression produced by seizures, having an impact on this complex disease, such as seizures or even in epileptogenesis.en
dc.publisherSpringer Natureen
dc.relation.urlhttp://link.springer.com/article/10.1007/s13668-017-0189-7en
dc.subjectEpilepsyen
dc.subjectDietary treatmenten
dc.subjectEpigeneticsen
dc.subjectBeta-hydroxybutyrateen
dc.subjectNicotinamide adenine dinucleotideen
dc.subjectS-Adenosyl methionineen
dc.titleThe Emerging Role of Epigenetics on Dietary Treatment for Epilepsyen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalCurrent Nutrition Reportsen
dc.contributor.institutionDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico, Mexicoen
dc.contributor.institutionInstituto de Fisiología Celular-Neurociencias, Universidad Nacional Autónoma de México, Mexico, Mexicoen
kaust.authorLandgrave Gomez, Jorgeen
kaust.authorVargas-Romero, Fernandaen
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