Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors

Handle URI:
http://hdl.handle.net/10754/623166
Title:
Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors
Authors:
Liu, Yijing; Yang, Xiangyu; Huang, Zhiqi; Huang, Peng; Zhang, Yang; Deng, Lin ( 0000-0001-8954-5610 ) ; Wang, Zhantong; Zhou, Zijian; Liu, Yi; Kalish, Heather; Khachab, Niveen M.; Chen, Xiaoyuan; Nie, Zhihong
Abstract:
Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto-plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2–3 times in the PA and MR imaging, compared with control groups without a magnetic field.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Chemical Science Program; Smart Hybrid Materials (SHMs) lab
Citation:
Liu Y, Yang X, Huang Z, Huang P, Zhang Y, et al. (2016) Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors. Angewandte Chemie International Edition 55: 15297–15300. Available: http://dx.doi.org/10.1002/anie.201608338.
Publisher:
Wiley-Blackwell
Journal:
Angewandte Chemie International Edition
KAUST Grant Number:
CRG-2015
Issue Date:
10-Nov-2016
DOI:
10.1002/anie.201608338; 10.1002/ange.201608338
Type:
Article
ISSN:
1433-7851
Sponsors:
Z.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377, CHE-1505839) and 3M Non-tenured Faculty Award. N.M.K. and Z.N. further acknowledge support provided by a King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health. P.H. acknowledges financial support from National Science Foundation of China (81401465, 51573096). We acknowledge Maryland NanoCenter and its NispLab. NispLab is supported, in part, by the NSF in partnership with MRSEC Shared Experimental Facilities.
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/anie.201608338/full
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorLiu, Yijingen
dc.contributor.authorYang, Xiangyuen
dc.contributor.authorHuang, Zhiqien
dc.contributor.authorHuang, Pengen
dc.contributor.authorZhang, Yangen
dc.contributor.authorDeng, Linen
dc.contributor.authorWang, Zhantongen
dc.contributor.authorZhou, Zijianen
dc.contributor.authorLiu, Yien
dc.contributor.authorKalish, Heatheren
dc.contributor.authorKhachab, Niveen M.en
dc.contributor.authorChen, Xiaoyuanen
dc.contributor.authorNie, Zhihongen
dc.date.accessioned2017-04-13T11:50:58Z-
dc.date.available2017-04-13T11:50:58Z-
dc.date.issued2016-11-10en
dc.identifier.citationLiu Y, Yang X, Huang Z, Huang P, Zhang Y, et al. (2016) Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors. Angewandte Chemie International Edition 55: 15297–15300. Available: http://dx.doi.org/10.1002/anie.201608338.en
dc.identifier.issn1433-7851en
dc.identifier.doi10.1002/anie.201608338en
dc.identifier.doi10.1002/ange.201608338en
dc.identifier.urihttp://hdl.handle.net/10754/623166-
dc.description.abstractMagneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto-plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2–3 times in the PA and MR imaging, compared with control groups without a magnetic field.en
dc.description.sponsorshipZ.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377, CHE-1505839) and 3M Non-tenured Faculty Award. N.M.K. and Z.N. further acknowledge support provided by a King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health. P.H. acknowledges financial support from National Science Foundation of China (81401465, 51573096). We acknowledge Maryland NanoCenter and its NispLab. NispLab is supported, in part, by the NSF in partnership with MRSEC Shared Experimental Facilities.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201608338/fullen
dc.subjectJanus vesiclesen
dc.subjectmagnetic resonance imagingen
dc.subjectnanoparticlesen
dc.subjectphotoacoustic imagingen
dc.subjectself-assemblyen
dc.titleMagneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumorsen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalAngewandte Chemie International Editionen
dc.contributor.institutionDepartment of Chemistry and Biochemistry; University of Maryland; College Park MD 20742 USAen
dc.contributor.institutionLaboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB); National Institutes of Health; USAen
dc.contributor.institutionTrans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS), National Institute of Biomedical Imaging and Bioengineering (NIBIB); National Institutes of Health; USAen
dc.contributor.institutionGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering; Shenzhen University; Shenzhen 518060 P.R. Chinaen
dc.contributor.institutionLiu, Yijingen
kaust.authorZhang, Yangen
kaust.authorDeng, Linen
kaust.authorKhachab, Niveen M.en
kaust.grant.numberCRG-2015en
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.