Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions

Handle URI:
http://hdl.handle.net/10754/623158
Title:
Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions
Authors:
El-Sepelgy, Osama; Alandini, Nurtalya; Rueping, Magnus ( 0000-0003-4580-5227 )
Abstract:
A dual catalytic iron/lipase system has been developed and applied in the dynamic kinetic resolution of benzylic and aliphatic secondary alcohols. A detailed study of the Knölker-type iron complexes demonstrated the hydrogen autotransfer of alcohols to proceed under mild reaction conditions and allowed the combination with the enzymatic resolution. Different racemic alcohols were efficiently converted to chiral acetates in good yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
KAUST Department:
KAUST Catalysis Center (KCC)
Citation:
El-Sepelgy O, Alandini N, Rueping M (2016) Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions. Angewandte Chemie International Edition 55: 13602–13605. Available: http://dx.doi.org/10.1002/anie.201606197.
Publisher:
Wiley-Blackwell
Journal:
Angewandte Chemie International Edition
Issue Date:
29-Sep-2016
DOI:
10.1002/anie.201606197; 10.1002/ange.201606197
Type:
Article
ISSN:
1433-7851
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/anie.201606197/abstract
Appears in Collections:
Articles; KAUST Catalysis Center (KCC)

Full metadata record

DC FieldValue Language
dc.contributor.authorEl-Sepelgy, Osamaen
dc.contributor.authorAlandini, Nurtalyaen
dc.contributor.authorRueping, Magnusen
dc.date.accessioned2017-04-13T11:50:58Z-
dc.date.available2017-04-13T11:50:58Z-
dc.date.issued2016-09-29en
dc.identifier.citationEl-Sepelgy O, Alandini N, Rueping M (2016) Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions. Angewandte Chemie International Edition 55: 13602–13605. Available: http://dx.doi.org/10.1002/anie.201606197.en
dc.identifier.issn1433-7851en
dc.identifier.doi10.1002/anie.201606197en
dc.identifier.doi10.1002/ange.201606197en
dc.identifier.urihttp://hdl.handle.net/10754/623158-
dc.description.abstractA dual catalytic iron/lipase system has been developed and applied in the dynamic kinetic resolution of benzylic and aliphatic secondary alcohols. A detailed study of the Knölker-type iron complexes demonstrated the hydrogen autotransfer of alcohols to proceed under mild reaction conditions and allowed the combination with the enzymatic resolution. Different racemic alcohols were efficiently converted to chiral acetates in good yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201606197/abstracten
dc.subjectchiral alcoholsen
dc.subjecthydrogenasesen
dc.subjectkinetic resolutionen
dc.subjectlipasesen
dc.subjectreductionen
dc.titleMerging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutionsen
dc.typeArticleen
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.identifier.journalAngewandte Chemie International Editionen
dc.contributor.institutionInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen, Germanyen
kaust.authorRueping, Magnusen
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