Division of Labor

Handle URI:
http://hdl.handle.net/10754/623132
Title:
Division of Labor
Authors:
Oke, Muse; Zaher, Manal S.; Hamdan, Samir ( 0000-0001-5192-1852 )
Abstract:
The first assignment of DNA polymerases at the eukaryotic replication fork was possible after the in vitro reconstitution of the simian virus 40 (SV40) replication system. In this system, DNA polymerase α (Pol α) provides both leading and lagging strands with RNA-DNA primers that are extended by DNA polymerase δ (Pol δ). Extrapolating the architecture of the replication fork from the SV40 model system to an actual eukaryotic cell has been challenged by the discovery of a third DNA polymerase in Saccharomyces cerevisiae, DNA polymerase ε (Pol ε). A division of labor has been proposed for the eukaryotic replication fork whereby Pol ε replicates the leading strand and Pol δ replicates the lagging strand. However, an alternative model of unequal division of labor in which Pol δ can still participate in leading-strand synthesis is plausible.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Laboratory of DNA Replication and Recombination
Citation:
Oke M, Zaher MS, Hamdan SM (2014) Division of Labor. Molecular Life Sciences: 1–5. Available: http://dx.doi.org/10.1007/978-1-4614-6436-5_134-1.
Publisher:
Springer Nature
Journal:
Molecular Life Sciences
Issue Date:
12-Sep-2014
DOI:
10.1007/978-1-4614-6436-5_134-1
Type:
Book Chapter
Additional Links:
http://link.springer.com/chapter/10.1007/978-1-4614-6436-5_134-1
Appears in Collections:
Book Chapters; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorOke, Museen
dc.contributor.authorZaher, Manal S.en
dc.contributor.authorHamdan, Samiren
dc.date.accessioned2017-04-13T11:50:56Z-
dc.date.available2017-04-13T11:50:56Z-
dc.date.issued2014-09-12en
dc.identifier.citationOke M, Zaher MS, Hamdan SM (2014) Division of Labor. Molecular Life Sciences: 1–5. Available: http://dx.doi.org/10.1007/978-1-4614-6436-5_134-1.en
dc.identifier.doi10.1007/978-1-4614-6436-5_134-1en
dc.identifier.urihttp://hdl.handle.net/10754/623132-
dc.description.abstractThe first assignment of DNA polymerases at the eukaryotic replication fork was possible after the in vitro reconstitution of the simian virus 40 (SV40) replication system. In this system, DNA polymerase α (Pol α) provides both leading and lagging strands with RNA-DNA primers that are extended by DNA polymerase δ (Pol δ). Extrapolating the architecture of the replication fork from the SV40 model system to an actual eukaryotic cell has been challenged by the discovery of a third DNA polymerase in Saccharomyces cerevisiae, DNA polymerase ε (Pol ε). A division of labor has been proposed for the eukaryotic replication fork whereby Pol ε replicates the leading strand and Pol δ replicates the lagging strand. However, an alternative model of unequal division of labor in which Pol δ can still participate in leading-strand synthesis is plausible.en
dc.publisherSpringer Natureen
dc.relation.urlhttp://link.springer.com/chapter/10.1007/978-1-4614-6436-5_134-1en
dc.titleDivision of Laboren
dc.typeBook Chapteren
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentLaboratory of DNA Replication and Recombinationen
dc.identifier.journalMolecular Life Sciencesen
kaust.authorOke, Museen
kaust.authorZaher, Manal S.en
kaust.authorHamdan, Samiren
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