Highly porous polytriazole ion exchange membranes cast from solutions in non-toxic cosolvents

Handle URI:
http://hdl.handle.net/10754/623090
Title:
Highly porous polytriazole ion exchange membranes cast from solutions in non-toxic cosolvents
Authors:
Chisca, Stefan; Torsello, Monica; Avanzato, Marco; Xie, Yihui ( 0000-0003-0159-9011 ) ; Boi, Cristiana; Nunes, Suzana Pereira ( 0000-0002-3669-138X )
Abstract:
The development of highly functionalized porous materials for protein separation is important for biotech processes. We report the preparation of highly porous polytriazole with sulfonic acid functionalization. The resulting ion exchange membranes are selective for protein adsorption. The starting material was a hydroxyl-functionalized polytriazole, which is an advantageous platform for further modification. The polymer was dissolved in a mixture of 1-ethyl-3-methylimidazolium acetate ([C2mim]OAc) and dimethyl carbonate (DMC), which can be both considered green solvents. The polymer solubilization was only possible due to an interesting effect of cosolvency, which is discussed, based in phase diagrams. Membranes were prepared by solution casting, followed by immersion in a non-solvent bath. We then grafted sulfone groups on the membranes, by reacting the hydroxyl groups with 1,3-propane sultone and 1,4-butane sultone. Lysozyme adsorption was successfully evaluated. Membranes modified with 1,4-butane sultone adsorbed more protein than those with 1,3-propane sultone.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Chisca S, Torsello M, Avanzato M, Xie Y, Boi C, et al. (2017) Highly porous polytriazole ion exchange membranes cast from solutions in non-toxic cosolvents. Polymer. Available: http://dx.doi.org/10.1016/j.polymer.2017.04.002.
Publisher:
Elsevier BV
Journal:
Polymer
Issue Date:
4-Apr-2017
DOI:
10.1016/j.polymer.2017.04.002
Type:
Article
ISSN:
0032-3861
Sponsors:
This research was supported by King Abdullah University of Science and Technology.
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0032386117303683
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorChisca, Stefanen
dc.contributor.authorTorsello, Monicaen
dc.contributor.authorAvanzato, Marcoen
dc.contributor.authorXie, Yihuien
dc.contributor.authorBoi, Cristianaen
dc.contributor.authorNunes, Suzana Pereiraen
dc.date.accessioned2017-04-10T07:49:51Z-
dc.date.available2017-04-10T07:49:51Z-
dc.date.issued2017-04-04en
dc.identifier.citationChisca S, Torsello M, Avanzato M, Xie Y, Boi C, et al. (2017) Highly porous polytriazole ion exchange membranes cast from solutions in non-toxic cosolvents. Polymer. Available: http://dx.doi.org/10.1016/j.polymer.2017.04.002.en
dc.identifier.issn0032-3861en
dc.identifier.doi10.1016/j.polymer.2017.04.002en
dc.identifier.urihttp://hdl.handle.net/10754/623090-
dc.description.abstractThe development of highly functionalized porous materials for protein separation is important for biotech processes. We report the preparation of highly porous polytriazole with sulfonic acid functionalization. The resulting ion exchange membranes are selective for protein adsorption. The starting material was a hydroxyl-functionalized polytriazole, which is an advantageous platform for further modification. The polymer was dissolved in a mixture of 1-ethyl-3-methylimidazolium acetate ([C2mim]OAc) and dimethyl carbonate (DMC), which can be both considered green solvents. The polymer solubilization was only possible due to an interesting effect of cosolvency, which is discussed, based in phase diagrams. Membranes were prepared by solution casting, followed by immersion in a non-solvent bath. We then grafted sulfone groups on the membranes, by reacting the hydroxyl groups with 1,3-propane sultone and 1,4-butane sultone. Lysozyme adsorption was successfully evaluated. Membranes modified with 1,4-butane sultone adsorbed more protein than those with 1,3-propane sultone.en
dc.description.sponsorshipThis research was supported by King Abdullah University of Science and Technology.en
dc.publisherElsevier BVen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0032386117303683en
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Polymer. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Polymer, 4 April 2017. DOI: 10.1016/j.polymer.2017.04.002. © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPolytriazoleen
dc.subjectHigh porous membraneen
dc.subjectGreen solventsen
dc.subjectIon exchange chromatographyen
dc.titleHighly porous polytriazole ion exchange membranes cast from solutions in non-toxic cosolventsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalPolymeren
dc.eprint.versionPost-printen
dc.contributor.institutionDipartimento di Ingegneria Civile, Chimica, Ambientale e dei Materiali, DICAM, Università di Bologna, via Terracini 28, 40131, Bologna, Italyen
kaust.authorChisca, Stefanen
kaust.authorXie, Yihuien
kaust.authorNunes, Suzana Pereiraen
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