Condition-specific RNA editing in the coral symbiont Symbiodinium microadriaticum

Handle URI:
http://hdl.handle.net/10754/623074
Title:
Condition-specific RNA editing in the coral symbiont Symbiodinium microadriaticum
Authors:
Liew, Yi Jin ( 0000-0003-2553-8870 ) ; Li, Yong ( 0000-0003-2609-2401 ) ; Baumgarten, Sebastian ( 0000-0003-2646-7699 ) ; Voolstra, Christian R. ( 0000-0003-4555-3795 ) ; Aranda, Manuel ( 0000-0001-6673-016X )
Abstract:
RNA editing is a rare post-transcriptional event that provides cells with an additional level of gene expression regulation. It has been implicated in various processes including adaptation, viral defence and RNA interference; however, its potential role as a mechanism in acclimatization has just recently been recognised. Here, we show that RNA editing occurs in 1.6% of all nuclear-encoded genes of Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals. All base-substitution edit types were present, and statistically significant motifs were associated with three edit types. Strikingly, a subset of genes exhibited condition-specific editing patterns in response to different stressors that resulted in significant increases of non-synonymous changes. We posit that this previously unrecognised mechanism extends this organism’s capability to respond to stress beyond what is encoded by the genome. This in turn may provide further acclimatization capacity to these organisms, and by extension, their coral hosts.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Red Sea Research Center (RSRC)
Citation:
Liew YJ, Li Y, Baumgarten S, Voolstra CR, Aranda M (2017) Condition-specific RNA editing in the coral symbiont Symbiodinium microadriaticum. PLOS Genetics 13: e1006619. Available: http://dx.doi.org/10.1371/journal.pgen.1006619.
Publisher:
Public Library of Science (PLoS)
Journal:
PLOS Genetics
Issue Date:
1-Mar-2017
DOI:
10.1371/journal.pgen.1006619
Type:
Article
ISSN:
1553-7404
Sponsors:
Research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Craig Michell for RNA-seq library construction, the KAUST Bioscience Core lab for library sequencing and Guoxin Cui for performing the differential expression analysis.
Additional Links:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006619
Appears in Collections:
Articles; Red Sea Research Center (RSRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLiew, Yi Jinen
dc.contributor.authorLi, Yongen
dc.contributor.authorBaumgarten, Sebastianen
dc.contributor.authorVoolstra, Christian R.en
dc.contributor.authorAranda, Manuelen
dc.date.accessioned2017-04-10T07:49:49Z-
dc.date.available2017-04-10T07:49:49Z-
dc.date.issued2017-03-01en
dc.identifier.citationLiew YJ, Li Y, Baumgarten S, Voolstra CR, Aranda M (2017) Condition-specific RNA editing in the coral symbiont Symbiodinium microadriaticum. PLOS Genetics 13: e1006619. Available: http://dx.doi.org/10.1371/journal.pgen.1006619.en
dc.identifier.issn1553-7404en
dc.identifier.doi10.1371/journal.pgen.1006619en
dc.identifier.urihttp://hdl.handle.net/10754/623074-
dc.description.abstractRNA editing is a rare post-transcriptional event that provides cells with an additional level of gene expression regulation. It has been implicated in various processes including adaptation, viral defence and RNA interference; however, its potential role as a mechanism in acclimatization has just recently been recognised. Here, we show that RNA editing occurs in 1.6% of all nuclear-encoded genes of Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals. All base-substitution edit types were present, and statistically significant motifs were associated with three edit types. Strikingly, a subset of genes exhibited condition-specific editing patterns in response to different stressors that resulted in significant increases of non-synonymous changes. We posit that this previously unrecognised mechanism extends this organism’s capability to respond to stress beyond what is encoded by the genome. This in turn may provide further acclimatization capacity to these organisms, and by extension, their coral hosts.en
dc.description.sponsorshipResearch reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Craig Michell for RNA-seq library construction, the KAUST Bioscience Core lab for library sequencing and Guoxin Cui for performing the differential expression analysis.en
dc.publisherPublic Library of Science (PLoS)en
dc.relation.urlhttp://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006619en
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleCondition-specific RNA editing in the coral symbiont Symbiodinium microadriaticumen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentRed Sea Research Center (RSRC)en
dc.identifier.journalPLOS Geneticsen
dc.eprint.versionPublisher's Version/PDFen
kaust.authorLiew, Yi Jinen
kaust.authorLi, Yongen
kaust.authorBaumgarten, Sebastianen
kaust.authorVoolstra, Christian R.en
kaust.authorAranda, Manuelen
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