Biocompatible 3D printed magnetic micro needles

Handle URI:
http://hdl.handle.net/10754/623023
Title:
Biocompatible 3D printed magnetic micro needles
Authors:
Kavaldzhiev, Mincho ( 0000-0003-1335-6797 ) ; Perez, Jose E. ( 0000-0002-2206-0034 ) ; Ivanov, Yurii; Bertoncini, Andrea; Liberale, Carlo ( 0000-0002-5653-199X ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
Biocompatible functional materials play a significant role in drug delivery, tissue engineering and single cell analysis. We utilized 3D printing to produce high aspect ratio polymer resist microneedles on a silicon substrate and functionalized them by iron coating. Two-photon polymerization lithography has been used for printing cylindrical, pyramidal, and conical needles from a drop cast IP-DIP resist. Experiments with cells were conducted with cylindrical microneedles with 630 ± 15 nm in diameter with an aspect ratio of 1:10 and pitch of 12 μm. The needles have been arranged in square shaped arrays with various dimensions. The iron coating of the needles was 120 ± 15 nm thick and has isotropic magnetic behavior. The chemical composition and oxidation state were determined using energy electron loss spectroscopy, revealing a mixture of iron and Fe3O4 clusters. A biocompatibility assessment was performed through fluorescence microscopy using calcein/EthD-1 live/dead assay. The results show a very high biocompatibility of the iron coated needle arrays. This study provides a strategy to obtain electromagnetically functional microneedles that benefit from the flexibility in terms of geometry and shape of 3D printing. Potential applications are in areas like tissue engineering, single cell analysis or drug delivery.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Kavaldzhiev M, Perez JE, Ivanov Y, Bertoncini A, Liberale C, et al. (2017) Biocompatible 3D printed magnetic micro needles. Biomedical Physics & Engineering Express 3: 025005. Available: http://dx.doi.org/10.1088/2057-1976/aa5ccb.
Publisher:
IOP Publishing
Journal:
Biomedical Physics & Engineering Express
Issue Date:
30-Jan-2017
DOI:
10.1088/2057-1976/aa5ccb
Type:
Article
ISSN:
2057-1976
Additional Links:
http://iopscience.iop.org/article/10.1088/2057-1976/aa5ccb/meta
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorKavaldzhiev, Minchoen
dc.contributor.authorPerez, Jose E.en
dc.contributor.authorIvanov, Yuriien
dc.contributor.authorBertoncini, Andreaen
dc.contributor.authorLiberale, Carloen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2017-03-20T07:50:09Z-
dc.date.available2017-03-20T07:50:09Z-
dc.date.issued2017-01-30en
dc.identifier.citationKavaldzhiev M, Perez JE, Ivanov Y, Bertoncini A, Liberale C, et al. (2017) Biocompatible 3D printed magnetic micro needles. Biomedical Physics & Engineering Express 3: 025005. Available: http://dx.doi.org/10.1088/2057-1976/aa5ccb.en
dc.identifier.issn2057-1976en
dc.identifier.doi10.1088/2057-1976/aa5ccben
dc.identifier.urihttp://hdl.handle.net/10754/623023-
dc.description.abstractBiocompatible functional materials play a significant role in drug delivery, tissue engineering and single cell analysis. We utilized 3D printing to produce high aspect ratio polymer resist microneedles on a silicon substrate and functionalized them by iron coating. Two-photon polymerization lithography has been used for printing cylindrical, pyramidal, and conical needles from a drop cast IP-DIP resist. Experiments with cells were conducted with cylindrical microneedles with 630 ± 15 nm in diameter with an aspect ratio of 1:10 and pitch of 12 μm. The needles have been arranged in square shaped arrays with various dimensions. The iron coating of the needles was 120 ± 15 nm thick and has isotropic magnetic behavior. The chemical composition and oxidation state were determined using energy electron loss spectroscopy, revealing a mixture of iron and Fe3O4 clusters. A biocompatibility assessment was performed through fluorescence microscopy using calcein/EthD-1 live/dead assay. The results show a very high biocompatibility of the iron coated needle arrays. This study provides a strategy to obtain electromagnetically functional microneedles that benefit from the flexibility in terms of geometry and shape of 3D printing. Potential applications are in areas like tissue engineering, single cell analysis or drug delivery.en
dc.publisherIOP Publishingen
dc.relation.urlhttp://iopscience.iop.org/article/10.1088/2057-1976/aa5ccb/metaen
dc.rightsThis is an author-created, un-copyedited version of an article accepted for publication/published in Biomedical Physics & Engineering Express. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://doi.org/10.1088/2057-1976/aa5ccben
dc.titleBiocompatible 3D printed magnetic micro needlesen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalBiomedical Physics & Engineering Expressen
dc.eprint.versionPost-printen
dc.contributor.institutionComputer, Electrical and Mathematical Science and Engineering, Kingdom of Saudi Arabiaen
dc.contributor.institutionErich Schmid Institute of Materials Science, Austrian Academy of Sciences, A-8700 Leoben, Jahnstraße 12, Austriaen
dc.contributor.institutionBiological and Environmental Sciences and Engineering, Kingdom of Saudi Arabiaen
kaust.authorKavaldzhiev, Minchoen
kaust.authorPerez, Jose E.en
kaust.authorLiberale, Carloen
kaust.authorKosel, Jürgenen
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