Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy?

Handle URI:
http://hdl.handle.net/10754/623004
Title:
Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy?
Authors:
Bajic, Vladan; B. Bajic, Vladimir; Zivkovic, Lada; Arendt, Thomas; Perry, George; Spremo-Potparevic, Biljana
Abstract:
Alzheimer’s disease (AD) is represented by neuronal loss and this loss is correlated to a constant state of neuronal instability induced by intrinsic and extrinsic factors. In this paper data is presented regarding the possible roles of late phase cell cycle proteins in normal and affected neurons with the goal that understanding the mechanisms involved in the regulation of these proteins may represent a novel strategy for AD treatment. The results demonstrate a relative differential pattern of expression of certain proteins (APC/C, Mad1 and Mad2, Bub R1, Bub1, CDK 11, cohesin subunit Rad 21 and astrin) in the AD brain versus age matched controls, and it is suggested that targeting these proteins might translate into potential treatments for AD. Although the data presented here is of some interest, the ability to translate such information into clinical applications is often a challenge.
KAUST Department:
Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
Bajic V, B. Bajic V, Zivkovic L, Arendt T, Perry G, et al. (2016) Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy? Journal of Systems and Integrative Neuroscience 3. Available: http://dx.doi.org/10.15761/jsin.1000143.
Publisher:
Open Access Text Pvt, Ltd.
Journal:
Journal of Systems and Integrative Neuroscience
Issue Date:
22-Feb-2017
DOI:
10.15761/jsin.1000143
Type:
Article
ISSN:
2059-9781
Sponsors:
Author thanks the Fulbright Association , German DAAD Association and the Ministry of Education, Science and Technological Development of the Republic of Serbia for financial support (Project No: 173034).
Additional Links:
http://oatext.com/Late-phase-cell-cycle-proteins-in-Alzheimers-disease-a-possible-target-for-therapy.php
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBajic, Vladanen
dc.contributor.authorB. Bajic, Vladimiren
dc.contributor.authorZivkovic, Ladaen
dc.contributor.authorArendt, Thomasen
dc.contributor.authorPerry, Georgeen
dc.contributor.authorSpremo-Potparevic, Biljanaen
dc.date.accessioned2017-03-15T07:15:27Z-
dc.date.available2017-03-15T07:15:27Z-
dc.date.issued2017-02-22en
dc.identifier.citationBajic V, B. Bajic V, Zivkovic L, Arendt T, Perry G, et al. (2016) Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy? Journal of Systems and Integrative Neuroscience 3. Available: http://dx.doi.org/10.15761/jsin.1000143.en
dc.identifier.issn2059-9781en
dc.identifier.doi10.15761/jsin.1000143en
dc.identifier.urihttp://hdl.handle.net/10754/623004-
dc.description.abstractAlzheimer’s disease (AD) is represented by neuronal loss and this loss is correlated to a constant state of neuronal instability induced by intrinsic and extrinsic factors. In this paper data is presented regarding the possible roles of late phase cell cycle proteins in normal and affected neurons with the goal that understanding the mechanisms involved in the regulation of these proteins may represent a novel strategy for AD treatment. The results demonstrate a relative differential pattern of expression of certain proteins (APC/C, Mad1 and Mad2, Bub R1, Bub1, CDK 11, cohesin subunit Rad 21 and astrin) in the AD brain versus age matched controls, and it is suggested that targeting these proteins might translate into potential treatments for AD. Although the data presented here is of some interest, the ability to translate such information into clinical applications is often a challenge.en
dc.description.sponsorshipAuthor thanks the Fulbright Association , German DAAD Association and the Ministry of Education, Science and Technological Development of the Republic of Serbia for financial support (Project No: 173034).en
dc.publisherOpen Access Text Pvt, Ltd.en
dc.relation.urlhttp://oatext.com/Late-phase-cell-cycle-proteins-in-Alzheimers-disease-a-possible-target-for-therapy.phpen
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectAlzheimer’s diseaseen
dc.subjectneuronal instabilityen
dc.titleLate phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy?en
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalJournal of Systems and Integrative Neuroscienceen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Radiobiology and Molecular Genetics, ‘’Vinca’’ Institute; PO Box 552, University of Belgrade, Belgrade, Serbiaen
dc.contributor.institutionDepartment of Endocrinology and Molecular Biology, ‘’Vinca’’ Institute; PO Box 552, Belgrade, Serbiaen
dc.contributor.institutionPaul-Flechsig-Institute for Brain Research, University of Leipzig, Medical Faculty, 04109, Leipzig, Germanyen
dc.contributor.institutionDepartment of Biology, The University of Texas at San Antonio, San Antonio, TX, 78249, USAen
kaust.authorB. Bajic, Vladimiren
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.