Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector

Handle URI:
http://hdl.handle.net/10754/622961
Title:
Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector
Authors:
Crawford, Jacob E.; Alves, Joel M.; Palmer, William J.; Day, Jonathan P.; Sylla, Massamba; Ramasamy, Ranjan; Surendran, Sinnathamby N.; Black, William C., IV; Pain, Arnab ( 0000-0002-1755-2819 ) ; Jiggins, Francis M.
Abstract:
BackgroundThe mosquito Aedes aegypti is the main vector of dengue, Zika, chikungunya and yellow fever viruses. This major disease vector is thought to have arisen when the African subspecies Ae. aegypti formosus evolved from being zoophilic and living in forest habitats into a form that specialises on humans and resides near human population centres. The resulting domestic subspecies, Ae. aegypti aegypti, is found throughout the tropics and largely blood-feeds on humans.ResultsTo understand this transition, we have sequenced the exomes of mosquitoes collected from five populations from around the world. We found that Ae. aegypti specimens from an urban population in Senegal in West Africa were more closely related to populations in Mexico and Sri Lanka than they were to a nearby forest population. We estimate that the populations in Senegal and Mexico split just a few hundred years ago, and we found no evidence of Ae. aegypti aegypti mosquitoes migrating back to Africa from elsewhere in the tropics. The out-of-Africa migration was accompanied by a dramatic reduction in effective population size, resulting in a loss of genetic diversity and rare genetic variants.ConclusionsWe conclude that a domestic population of Ae. aegypti in Senegal and domestic populations on other continents are more closely related to each other than to other African populations. This suggests that an ancestral population of Ae. aegypti evolved to become a human specialist in Africa, giving rise to the subspecies Ae. aegypti aegypti. The descendants of this population are still found in West Africa today, and the rest of the world was colonised when mosquitoes from this population migrated out of Africa. This is the first report of an African population of Ae. aegypti aegypti mosquitoes that is closely related to Asian and American populations. As the two subspecies differ in their ability to vector disease, their existence side by side in West Africa may have important implications for disease transmission.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Crawford JE, Alves JM, Palmer WJ, Day JP, Sylla M, et al. (2017) Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector. BMC Biology 15. Available: http://dx.doi.org/10.1186/s12915-017-0351-0.
Publisher:
Springer Nature
Journal:
BMC Biology
Issue Date:
20-Feb-2017
DOI:
10.1186/s12915-017-0351-0
PubMed ID:
28241828
PubMed Central ID:
PMC5329927
Type:
Article
ISSN:
1741-7007
Sponsors:
This work was funded by European Research Council grant Drosophila Infection 281668 to FMJ, a KAUST AEA award to FMJ and AP, a Medical Research Council Centenary Award to WJP and a National Institutes of Health Ruth L. Kirschstein National Research Service Award to JC.
Additional Links:
http://link.springer.com/article/10.1186/s12915-017-0351-0
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorCrawford, Jacob E.en
dc.contributor.authorAlves, Joel M.en
dc.contributor.authorPalmer, William J.en
dc.contributor.authorDay, Jonathan P.en
dc.contributor.authorSylla, Massambaen
dc.contributor.authorRamasamy, Ranjanen
dc.contributor.authorSurendran, Sinnathamby N.en
dc.contributor.authorBlack, William C., IVen
dc.contributor.authorPain, Arnaben
dc.contributor.authorJiggins, Francis M.en
dc.date.accessioned2017-03-05T06:13:15Z-
dc.date.available2017-03-05T06:13:15Z-
dc.date.issued2017-02-20en
dc.identifier.citationCrawford JE, Alves JM, Palmer WJ, Day JP, Sylla M, et al. (2017) Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector. BMC Biology 15. Available: http://dx.doi.org/10.1186/s12915-017-0351-0.en
dc.identifier.issn1741-7007en
dc.identifier.pmid28241828en
dc.identifier.doi10.1186/s12915-017-0351-0en
dc.identifier.urihttp://hdl.handle.net/10754/622961-
dc.description.abstractBackgroundThe mosquito Aedes aegypti is the main vector of dengue, Zika, chikungunya and yellow fever viruses. This major disease vector is thought to have arisen when the African subspecies Ae. aegypti formosus evolved from being zoophilic and living in forest habitats into a form that specialises on humans and resides near human population centres. The resulting domestic subspecies, Ae. aegypti aegypti, is found throughout the tropics and largely blood-feeds on humans.ResultsTo understand this transition, we have sequenced the exomes of mosquitoes collected from five populations from around the world. We found that Ae. aegypti specimens from an urban population in Senegal in West Africa were more closely related to populations in Mexico and Sri Lanka than they were to a nearby forest population. We estimate that the populations in Senegal and Mexico split just a few hundred years ago, and we found no evidence of Ae. aegypti aegypti mosquitoes migrating back to Africa from elsewhere in the tropics. The out-of-Africa migration was accompanied by a dramatic reduction in effective population size, resulting in a loss of genetic diversity and rare genetic variants.ConclusionsWe conclude that a domestic population of Ae. aegypti in Senegal and domestic populations on other continents are more closely related to each other than to other African populations. This suggests that an ancestral population of Ae. aegypti evolved to become a human specialist in Africa, giving rise to the subspecies Ae. aegypti aegypti. The descendants of this population are still found in West Africa today, and the rest of the world was colonised when mosquitoes from this population migrated out of Africa. This is the first report of an African population of Ae. aegypti aegypti mosquitoes that is closely related to Asian and American populations. As the two subspecies differ in their ability to vector disease, their existence side by side in West Africa may have important implications for disease transmission.en
dc.description.sponsorshipThis work was funded by European Research Council grant Drosophila Infection 281668 to FMJ, a KAUST AEA award to FMJ and AP, a Medical Research Council Centenary Award to WJP and a National Institutes of Health Ruth L. Kirschstein National Research Service Award to JC.en
dc.publisherSpringer Natureen
dc.relation.urlhttp://link.springer.com/article/10.1186/s12915-017-0351-0en
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAedes aegyptien
dc.subjectAnthropophilicen
dc.subjectDengue virusen
dc.subjectZika virusen
dc.subjectArboviral diseasesen
dc.subjectMosquito evolutionen
dc.subjectVector-borne diseasesen
dc.titlePopulation genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vectoren
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalBMC Biologyen
dc.identifier.pmcidPMC5329927en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Integrative Biology, University of California, Berkeley, CA 94720-3140, USAen
dc.contributor.institutionVerily Life Sciences, South San Francisco, CA 94080, USAen
dc.contributor.institutionDepartment of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UKen
dc.contributor.institutionCIBIO/InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, 4485-661 Vairão, Portugalen
dc.contributor.institutionDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USAen
dc.contributor.institutionID-FISH Technology, Palo Alto, CA 94303, USAen
dc.contributor.institutionDepartment of Zoology, University of Jaffna, Jaffna, Sri Lankaen
kaust.authorPain, Arnaben

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