Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine

Handle URI:
http://hdl.handle.net/10754/622925
Title:
Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine
Authors:
Nanda, Himansu Sekhar ( 0000-0001-5543-3565 )
Abstract:
The biocompatible surface modification of metal oxide nanoparticles via surface functionalization technique has been used as an important tool in nanotechnology and medicine. In this report, we have prepared aqueous dispersible, trivalent metal ion (samarium)-doped cerium oxide nanoparticles (SmCNPs) as model redox altered CNPs of biological relevance. SmCNP surface modified with hydrophilic biocompatible (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl) triethoxysilane (MEEETES) were prepared using ammonia-induced ethylene glycol-assisted precipitation method and were characterized using a variety of complementary characterization techniques. The chemical interaction of functional moieties with the surface of doped nanoparticle was studied using powerful 13C cross polarization magic angle sample spinning nuclear magnetic resonance spectroscopy. The results demonstrated the production of the extremely small size MEEETES surface modified doped nanoparticles with significant reduction in aggregation compared to their unmodified state. Moreover, the functional moieties had strong chemical interaction with the surface of the doped nanoparticles. The biocompatible surface modification using MEEETES should also be extended to several other transition metal ion doped and co-doped CNPs for the production of aqueous dispersible redox altered CNPs that are promising for nanobiology and medicine.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
Nanda H (2016) Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine. Bioengineering 3: 28. Available: http://dx.doi.org/10.3390/bioengineering3040028.
Publisher:
MDPI AG
Journal:
Bioengineering
Issue Date:
3-Nov-2016
DOI:
10.3390/bioengineering3040028
Type:
Article
ISSN:
2306-5354
Sponsors:
The author would like to acknowledge the financial support from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia.
Additional Links:
http://www.mdpi.com/2306-5354/3/4/28
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorNanda, Himansu Sekharen
dc.date.accessioned2017-02-26T06:34:21Z-
dc.date.available2017-02-26T06:34:21Z-
dc.date.issued2016-11-03en
dc.identifier.citationNanda H (2016) Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine. Bioengineering 3: 28. Available: http://dx.doi.org/10.3390/bioengineering3040028.en
dc.identifier.issn2306-5354en
dc.identifier.doi10.3390/bioengineering3040028en
dc.identifier.urihttp://hdl.handle.net/10754/622925-
dc.description.abstractThe biocompatible surface modification of metal oxide nanoparticles via surface functionalization technique has been used as an important tool in nanotechnology and medicine. In this report, we have prepared aqueous dispersible, trivalent metal ion (samarium)-doped cerium oxide nanoparticles (SmCNPs) as model redox altered CNPs of biological relevance. SmCNP surface modified with hydrophilic biocompatible (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl) triethoxysilane (MEEETES) were prepared using ammonia-induced ethylene glycol-assisted precipitation method and were characterized using a variety of complementary characterization techniques. The chemical interaction of functional moieties with the surface of doped nanoparticle was studied using powerful 13C cross polarization magic angle sample spinning nuclear magnetic resonance spectroscopy. The results demonstrated the production of the extremely small size MEEETES surface modified doped nanoparticles with significant reduction in aggregation compared to their unmodified state. Moreover, the functional moieties had strong chemical interaction with the surface of the doped nanoparticles. The biocompatible surface modification using MEEETES should also be extended to several other transition metal ion doped and co-doped CNPs for the production of aqueous dispersible redox altered CNPs that are promising for nanobiology and medicine.en
dc.description.sponsorshipThe author would like to acknowledge the financial support from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia.en
dc.publisherMDPI AGen
dc.relation.urlhttp://www.mdpi.com/2306-5354/3/4/28en
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).en
dc.subjectcerium oxide nanoparticleen
dc.subjectbiocompatibleen
dc.subjectsurface modificationen
dc.subjectaqueous dispersibleen
dc.subjectdoped and co-dopeden
dc.subjectnanobiology and medicineen
dc.titlePreparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicineen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalBioengineeringen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionSchool of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singaporeen
kaust.authorNanda, Himansu Sekharen
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