Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections

Handle URI:
http://hdl.handle.net/10754/622886
Title:
Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections
Authors:
Alsaiari, Shahad K.; Hammami, Mohamed Amen ( 0000-0002-6162-3629 ) ; Croissant, Jonas G.; Omar, Haneen; Neelakanda, Pradeep; Yapici, Tahir; Peinemann, Klaus-Viktor ( 0000-0003-0309-9598 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Healthcare-associated infections (HAIs) are the infections that patients get while receiving medical treatment in a medical facility with bacterial HAIs being the most common. Silver and gold nanoparticles (NPs) have been successfully employed as antibacterial motifs; however, NPs leaching in addition to poor dispersion and overall reproducibility are major hurdles to further product development. In this study, the authors design and fabricate a smart antibacterial mixed-matrix membrane coating comprising colloidal lysozyme-templated gold nanoclusters as nanofillers in poly(ethylene oxide)/poly(butylene terephthalate) amphiphilic polymer matrix. Mesoporous silica nanoparticles-lysozyme functionalized gold nanoclusters disperse homogenously within the polymer matrix with no phase separation and zero NPs leaching. This mixed-matrix coating can successfully sense and inhibit bacterial contamination via a controlled release mechanism that is only triggered by bacteria. The system is coated on a common radiographic dental imaging device (photostimulable phosphor plate) that is prone to oral bacteria contamination. Variation and eventually disappearance of the red fluorescence surface under UV light signals bacterial infection. Kanamycin, an antimicrobial agent, is controllably released to instantly inhibit bacterial growth. Interestingly, the quality of the images obtained with these coated surfaces is the same as uncoated surfaces and thus the safe application of such smart coatings can be expanded to include other medical devices without compromising their utility.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab; Analytical Core Lab
Citation:
Alsaiari SK, Hammami MA, Croissant JG, Omar HW, Neelakanda P, et al. (2017) Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections. Advanced Healthcare Materials: 1601135. Available: http://dx.doi.org/10.1002/adhm.201601135.
Publisher:
Wiley-Blackwell
Journal:
Advanced Healthcare Materials
Issue Date:
25-Jan-2017
DOI:
10.1002/adhm.201601135
Type:
Article
ISSN:
2192-2640
Sponsors:
S.K.A. and M.A.H. contributed equally to this work. The authors gratefully acknowledge Dr. Abdallah Abdallah from King Abdullah University of Science and Technology (KAUST) for providing E. coli. The authors also thank Dr. Asma'a A. Al-Ekrish from King Saud University and Dr. Alhasan Alsaiari from King Abdulaziz University College of Dentistry for providing and testing the dental imaging plates. The authors declare no competing financial interest.
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201601135/full
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Analytical Core Lab; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorAlsaiari, Shahad K.en
dc.contributor.authorHammami, Mohamed Amenen
dc.contributor.authorCroissant, Jonas G.en
dc.contributor.authorOmar, Haneenen
dc.contributor.authorNeelakanda, Pradeepen
dc.contributor.authorYapici, Tahiren
dc.contributor.authorPeinemann, Klaus-Viktoren
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2017-02-15T08:32:14Z-
dc.date.available2017-02-15T08:32:14Z-
dc.date.issued2017-01-25en
dc.identifier.citationAlsaiari SK, Hammami MA, Croissant JG, Omar HW, Neelakanda P, et al. (2017) Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections. Advanced Healthcare Materials: 1601135. Available: http://dx.doi.org/10.1002/adhm.201601135.en
dc.identifier.issn2192-2640en
dc.identifier.doi10.1002/adhm.201601135en
dc.identifier.urihttp://hdl.handle.net/10754/622886-
dc.description.abstractHealthcare-associated infections (HAIs) are the infections that patients get while receiving medical treatment in a medical facility with bacterial HAIs being the most common. Silver and gold nanoparticles (NPs) have been successfully employed as antibacterial motifs; however, NPs leaching in addition to poor dispersion and overall reproducibility are major hurdles to further product development. In this study, the authors design and fabricate a smart antibacterial mixed-matrix membrane coating comprising colloidal lysozyme-templated gold nanoclusters as nanofillers in poly(ethylene oxide)/poly(butylene terephthalate) amphiphilic polymer matrix. Mesoporous silica nanoparticles-lysozyme functionalized gold nanoclusters disperse homogenously within the polymer matrix with no phase separation and zero NPs leaching. This mixed-matrix coating can successfully sense and inhibit bacterial contamination via a controlled release mechanism that is only triggered by bacteria. The system is coated on a common radiographic dental imaging device (photostimulable phosphor plate) that is prone to oral bacteria contamination. Variation and eventually disappearance of the red fluorescence surface under UV light signals bacterial infection. Kanamycin, an antimicrobial agent, is controllably released to instantly inhibit bacterial growth. Interestingly, the quality of the images obtained with these coated surfaces is the same as uncoated surfaces and thus the safe application of such smart coatings can be expanded to include other medical devices without compromising their utility.en
dc.description.sponsorshipS.K.A. and M.A.H. contributed equally to this work. The authors gratefully acknowledge Dr. Abdallah Abdallah from King Abdullah University of Science and Technology (KAUST) for providing E. coli. The authors also thank Dr. Asma'a A. Al-Ekrish from King Saud University and Dr. Alhasan Alsaiari from King Abdulaziz University College of Dentistry for providing and testing the dental imaging plates. The authors declare no competing financial interest.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/adhm.201601135/fullen
dc.subjectControlled releaseen
dc.subjectMesoporous Silica Nanoparticlesen
dc.subjectGold Nanoclustersen
dc.subjectMixed Matrix Membranesen
dc.subjectAntibacterial Surfacesen
dc.titleColloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infectionsen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAnalytical Core Laben
dc.identifier.journalAdvanced Healthcare Materialsen
kaust.authorAlsaiari, Shahad K.en
kaust.authorHammami, Mohamed Amenen
kaust.authorCroissant, Jonas G.en
kaust.authorOmar, Haneenen
kaust.authorNeelakanda, Pradeepen
kaust.authorYapici, Tahiren
kaust.authorPeinemann, Klaus-Viktoren
kaust.authorKhashab, Niveen M.en
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