Transposable elements and circular DNAs

Handle URI:
http://hdl.handle.net/10754/622823
Title:
Transposable elements and circular DNAs
Authors:
Mourier, Tobias
Abstract:
Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs). Similarly, circular DNAs can be generated by recombination between LTRs residing at different genomic loci, in which case the circular DNA will contain the intervening sequence. In yeast, this can result in gene copy number variations when circles contain genes and origins of replication. Here, I speculate on the potential and implications of circular DNAs generated through recombination between human transposable elements.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Pathogen Genomics Laboratory
Citation:
Mourier T (2016) Transposable elements and circular DNAs. Mobile Genetic Elements 6: e1240748. Available: http://dx.doi.org/10.1080/2159256x.2016.1240748.
Publisher:
Informa UK Limited
Journal:
Mobile Genetic Elements
Issue Date:
26-Sep-2016
DOI:
10.1080/2159256x.2016.1240748
Type:
Article
ISSN:
2159-256X
Additional Links:
http://www.tandfonline.com/doi/full/10.1080/2159256X.2016.1240748
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMourier, Tobiasen
dc.date.accessioned2017-01-30T13:02:47Z-
dc.date.available2017-01-30T13:02:47Z-
dc.date.issued2016-09-26en
dc.identifier.citationMourier T (2016) Transposable elements and circular DNAs. Mobile Genetic Elements 6: e1240748. Available: http://dx.doi.org/10.1080/2159256x.2016.1240748.en
dc.identifier.issn2159-256Xen
dc.identifier.doi10.1080/2159256x.2016.1240748en
dc.identifier.urihttp://hdl.handle.net/10754/622823-
dc.description.abstractCircular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs). Similarly, circular DNAs can be generated by recombination between LTRs residing at different genomic loci, in which case the circular DNA will contain the intervening sequence. In yeast, this can result in gene copy number variations when circles contain genes and origins of replication. Here, I speculate on the potential and implications of circular DNAs generated through recombination between human transposable elements.en
dc.publisherInforma UK Limiteden
dc.relation.urlhttp://www.tandfonline.com/doi/full/10.1080/2159256X.2016.1240748en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGenomeen
dc.subjectHumanen
dc.subjectEvolutionen
dc.subjectYeasten
dc.subjectAlu Elementsen
dc.subjectCircular Dnasen
dc.subjectEccdnasen
dc.titleTransposable elements and circular DNAsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentPathogen Genomics Laboratoryen
dc.identifier.journalMobile Genetic Elementsen
dc.eprint.versionPublisher's Version/PDFen
kaust.authorMourier, Tobiasen
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