Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles

Handle URI:
http://hdl.handle.net/10754/622803
Title:
Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles
Authors:
Croissant, Jonas G.; Fatieiev, Yevhen ( 0000-0002-2844-8427 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
The biorelated degradability and clearance of siliceous nanomaterials have been questioned worldwide, since they are crucial prerequisites for the successful translation in clinics. Typically, the degradability and biocompatibility of mesoporous silica nanoparticles (MSNs) have been an ongoing discussion in research circles. The reason for such a concern is that approved pharmaceutical products must not accumulate in the human body, to prevent severe and unpredictable side-effects. Here, the biorelated degradability and clearance of silicon and silica nanoparticles (NPs) are comprehensively summarized. The influence of the size, morphology, surface area, pore size, and surface functional groups, to name a few, on the degradability of silicon and silica NPs is described. The noncovalent organic doping of silica and the covalent incorporation of either hydrolytically stable or redox- and enzymatically cleavable silsesquioxanes is then described for organosilica, bridged silsesquioxane (BS), and periodic mesoporous organosilica (PMO) NPs. Inorganically doped silica particles such as calcium-, iron-, manganese-, and zirconium-doped NPs, also have radically different hydrolytic stabilities. To conclude, the degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanomaterial in this large family according to the targeted applications and the required clearance kinetics.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab
Citation:
Croissant JG, Fatieiev Y, Khashab NM (2017) Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles. Advanced Materials: 1604634. Available: http://dx.doi.org/10.1002/adma.201604634.
Publisher:
Wiley-Blackwell
Journal:
Advanced Materials
Issue Date:
13-Jan-2017
DOI:
10.1002/adma.201604634
Type:
Article
ISSN:
0935-9648
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/adma.201604634/full
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorCroissant, Jonas G.en
dc.contributor.authorFatieiev, Yevhenen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2017-01-29T13:51:40Z-
dc.date.available2017-01-29T13:51:40Z-
dc.date.issued2017-01-13en
dc.identifier.citationCroissant JG, Fatieiev Y, Khashab NM (2017) Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles. Advanced Materials: 1604634. Available: http://dx.doi.org/10.1002/adma.201604634.en
dc.identifier.issn0935-9648en
dc.identifier.doi10.1002/adma.201604634en
dc.identifier.urihttp://hdl.handle.net/10754/622803-
dc.description.abstractThe biorelated degradability and clearance of siliceous nanomaterials have been questioned worldwide, since they are crucial prerequisites for the successful translation in clinics. Typically, the degradability and biocompatibility of mesoporous silica nanoparticles (MSNs) have been an ongoing discussion in research circles. The reason for such a concern is that approved pharmaceutical products must not accumulate in the human body, to prevent severe and unpredictable side-effects. Here, the biorelated degradability and clearance of silicon and silica nanoparticles (NPs) are comprehensively summarized. The influence of the size, morphology, surface area, pore size, and surface functional groups, to name a few, on the degradability of silicon and silica NPs is described. The noncovalent organic doping of silica and the covalent incorporation of either hydrolytically stable or redox- and enzymatically cleavable silsesquioxanes is then described for organosilica, bridged silsesquioxane (BS), and periodic mesoporous organosilica (PMO) NPs. Inorganically doped silica particles such as calcium-, iron-, manganese-, and zirconium-doped NPs, also have radically different hydrolytic stabilities. To conclude, the degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanomaterial in this large family according to the targeted applications and the required clearance kinetics.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/adma.201604634/fullen
dc.subjectClearanceen
dc.subjectBiodegradableen
dc.subjectMesoporous Silica Nanoparticlesen
dc.subjectSilicon Nanoparticlesen
dc.subjectOrganosilica Nanoparticlesen
dc.titleDegradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticlesen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalAdvanced Materialsen
kaust.authorCroissant, Jonas G.en
kaust.authorFatieiev, Yevhenen
kaust.authorKhashab, Niveen M.en
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