Method of inhibiting plant virus pathogen infections by crispr/cas9-mediated interference

Handle URI:
http://hdl.handle.net/10754/622697
Title:
Method of inhibiting plant virus pathogen infections by crispr/cas9-mediated interference
Authors:
Mahfouz, Magdy Mahmoud ( 0000-0002-0616-6365 ) ; Ali, Zahir ( 0000-0002-7814-8908 )
Assignee:
King Abdullah University Of Science And Technology
Abstract:
A genetically modified tobacco plant or tomato plant resistant to at least one pathogenic geminiviridae virus species is provided. The plant comprises a heterologous CRISPR/Cas9 system and at least one heterologous nucleotide sequence that is capable of hybridizing to a nucleotide sequence of the pathogenic virus and that directs inactivation of the pathogenic virus species or plurality of viral species by the CRISPR/Cas9 system. The heterologous nucleotide sequence can be complementary to, but not limited to an Intergenic Region (IR) of the Tomato Yellow Leaf Curl Virus (TYLCV), Further provided are methods of generating a genetically modified plant that is resistant to a virus pathogen by a heterologous CRISPR/Cas9 system and expression of a gRNA specifically targeting the virus.
KAUST Department:
Biological, Environmental Sciences & Engineering Division
Issue Date:
24-Nov-2016
Submitted date:
2015-05-18
Type:
Patent
Application Number:
WO 2016185411 A1
Patent Status:
Published Application
Additional Links:
http://www.google.com/patents/WO2016185411A1; http://worldwide.espacenet.com/publicationDetails/biblio?CC=WO&NR=2016185411A1&KC=A1&FT=D
Appears in Collections:
Patents

Full metadata record

DC FieldValue Language
dc.contributor.authorMahfouz, Magdy Mahmouden
dc.contributor.authorAli, Zahiren
dc.date.accessioned2017-01-19T07:02:57Z-
dc.date.available2017-01-19T07:02:57Z-
dc.date.issued2016-11-24-
dc.date.submitted2015-05-18-
dc.identifier.urihttp://hdl.handle.net/10754/622697-
dc.description.abstractA genetically modified tobacco plant or tomato plant resistant to at least one pathogenic geminiviridae virus species is provided. The plant comprises a heterologous CRISPR/Cas9 system and at least one heterologous nucleotide sequence that is capable of hybridizing to a nucleotide sequence of the pathogenic virus and that directs inactivation of the pathogenic virus species or plurality of viral species by the CRISPR/Cas9 system. The heterologous nucleotide sequence can be complementary to, but not limited to an Intergenic Region (IR) of the Tomato Yellow Leaf Curl Virus (TYLCV), Further provided are methods of generating a genetically modified plant that is resistant to a virus pathogen by a heterologous CRISPR/Cas9 system and expression of a gRNA specifically targeting the virus.en
dc.relation.urlhttp://www.google.com/patents/WO2016185411A1en
dc.relation.urlhttp://worldwide.espacenet.com/publicationDetails/biblio?CC=WO&NR=2016185411A1&KC=A1&FT=Den
dc.titleMethod of inhibiting plant virus pathogen infections by crispr/cas9-mediated interferenceen
dc.typePatenten
dc.contributor.departmentBiological, Environmental Sciences & Engineering Divisionen
dc.description.statusPublished Applicationen
dc.contributor.assigneeKing Abdullah University Of Science And Technologyen
dc.description.countryWorld Intellectual Property Organization (WIPO)en
dc.identifier.applicationnumberWO 2016185411 A1en
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