Ground rules of the pluripotency gene regulatory network.

Handle URI:
http://hdl.handle.net/10754/622673
Title:
Ground rules of the pluripotency gene regulatory network.
Authors:
Li, Mo ( 0000-0003-0827-8907 ) ; Belmonte, Juan Carlos Izpisua
Abstract:
Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Ground rules of the pluripotency gene regulatory network. 2017 Nat. Rev. Genet.
Publisher:
Springer Nature
Journal:
Nature Reviews Genetics
Issue Date:
3-Jan-2017
DOI:
10.1038/nrg.2016.156
PubMed ID:
28045100
Type:
Article
ISSN:
1471-0064
Sponsors:
The authors apologize to the colleagues whose work is not covered in this article because of space constraints. The authors would like to thank D. O'Keefe and M. Schwarz for critical reading and generous help during the preparation of the manuscript. Work in the laboratory of J.C.I.B. is supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant 2012-PG-MED002), the Moxie Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
Additional Links:
http://www.nature.com/nrg/journal/vaop/ncurrent/full/nrg.2016.156.html
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Moen
dc.contributor.authorBelmonte, Juan Carlos Izpisuaen
dc.date.accessioned2017-01-10T13:59:56Z-
dc.date.available2017-01-10T13:59:56Z-
dc.date.issued2017-01-03-
dc.identifier.citationGround rules of the pluripotency gene regulatory network. 2017 Nat. Rev. Genet.en
dc.identifier.issn1471-0064-
dc.identifier.pmid28045100-
dc.identifier.doi10.1038/nrg.2016.156-
dc.identifier.urihttp://hdl.handle.net/10754/622673-
dc.description.abstractPluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.en
dc.description.sponsorshipThe authors apologize to the colleagues whose work is not covered in this article because of space constraints. The authors would like to thank D. O'Keefe and M. Schwarz for critical reading and generous help during the preparation of the manuscript. Work in the laboratory of J.C.I.B. is supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant 2012-PG-MED002), the Moxie Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).en
dc.language.isoenen
dc.language.isoen-
dc.publisherSpringer Natureen
dc.relation.urlhttp://www.nature.com/nrg/journal/vaop/ncurrent/full/nrg.2016.156.htmlen
dc.rightsArchived with thanks to Nature reviews. Geneticsen
dc.subjectpluripotent stem cellsen
dc.subjectGene Expression Regulationen
dc.titleGround rules of the pluripotency gene regulatory network.en
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalNature Reviews Geneticsen
dc.eprint.versionPost-printen
dc.contributor.institutionSalk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.en
dc.contributor.institutionUniversidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, No. 135 Guadalupe 30107, Murcia, Spain.en
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorLi, Moen

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