Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa

Handle URI:
http://hdl.handle.net/10754/622517
Title:
Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa
Authors:
Gallego Llorente, M.; Jones, E. R.; Eriksson, Anders ( 0000-0003-3436-3726 ) ; Siska, V.; Arthur, K. W.; Arthur, J. W.; Curtis, M. C.; Stock, J. T.; Coltorti, M.; Pieruccini, P.; Stretton, S.; Brock, F.; Higham, T.; Park, Y.; Hofreiter, M.; Bradley, D. G.; Bhak, J.; Pinhasi, R.; Manica, A.
Abstract:
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5×coverage ancient genome of an Ethiopian male ("Mota") who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Integrative Systems Biology Lab
Citation:
Llorente MG, Jones ER, Eriksson A, Siska V, Arthur KW, et al. (2015) Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa. Science 350: 820–822. Available: http://dx.doi.org/10.1126/science.aad2879.
Publisher:
American Association for the Advancement of Science (AAAS)
Journal:
Science
Issue Date:
9-Oct-2015
DOI:
10.1126/science.aad2879
PubMed ID:
26449472
Type:
Article
ISSN:
0036-8075; 1095-9203
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGallego Llorente, M.en
dc.contributor.authorJones, E. R.en
dc.contributor.authorEriksson, Andersen
dc.contributor.authorSiska, V.en
dc.contributor.authorArthur, K. W.en
dc.contributor.authorArthur, J. W.en
dc.contributor.authorCurtis, M. C.en
dc.contributor.authorStock, J. T.en
dc.contributor.authorColtorti, M.en
dc.contributor.authorPieruccini, P.en
dc.contributor.authorStretton, S.en
dc.contributor.authorBrock, F.en
dc.contributor.authorHigham, T.en
dc.contributor.authorPark, Y.en
dc.contributor.authorHofreiter, M.en
dc.contributor.authorBradley, D. G.en
dc.contributor.authorBhak, J.en
dc.contributor.authorPinhasi, R.en
dc.contributor.authorManica, A.en
dc.date.accessioned2017-01-02T09:55:27Z-
dc.date.available2017-01-02T09:55:27Z-
dc.date.issued2015-10-09en
dc.identifier.citationLlorente MG, Jones ER, Eriksson A, Siska V, Arthur KW, et al. (2015) Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa. Science 350: 820–822. Available: http://dx.doi.org/10.1126/science.aad2879.en
dc.identifier.issn0036-8075en
dc.identifier.issn1095-9203en
dc.identifier.pmid26449472en
dc.identifier.doi10.1126/science.aad2879en
dc.identifier.urihttp://hdl.handle.net/10754/622517-
dc.description.abstractCharacterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5×coverage ancient genome of an Ethiopian male ("Mota") who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.en
dc.publisherAmerican Association for the Advancement of Science (AAAS)en
dc.titleAncient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africaen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentIntegrative Systems Biology Laben
dc.identifier.journalScienceen
dc.contributor.institutionDepartment of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, United Kingdomen
dc.contributor.institutionSmurfit Institute of Genetics, Trinity College Dublin, I-Dublin, Irelanden
dc.contributor.institutionDepartment of Society, Culture, and Language, University of South Florida St. Petersburg, 140 7th Avenue South, St. Petersburg, FL, 33701, United Statesen
dc.contributor.institutionDepartment of Anthropology, Ventura College, 4667 Telegraph Road, Ventura, CA, 93003, United Statesen
dc.contributor.institutionHumanities and Social Sciences Program, UCLA Extension, University of California Los Angeles, 10995 Le Conte Avenue, Los Angeles, CA, 90095, United Statesen
dc.contributor.institutionDepartment of Archaeology and Anthropology, University of Cambridge, Pembroke Street, Cambridge, CB2 3QG, United Kingdomen
dc.contributor.institutionDepartment of Physical Sciences, Earth and Environment, University of Siena, Via di Laterina, 8, Siena, 53100, Italyen
dc.contributor.institutionDepartment of Anthropology, University of Illinois at Urbana-Champaign, Public Service Archaeology and Architecture Program, 109 Davenport Hall, 607 South Mathews Avenue, Urbana, IL, 61801, United Statesen
dc.contributor.institutionOxford Radiocarbon Accelerator Unit, Research Laboratory for Archaeology and the History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford, OX1 3QY, United Kingdomen
dc.contributor.institutionCranfield Forensic Institute, Cranfield University, Defence Academy of the United Kingdom, Shrivenham, Oxon, SN6 8LA, United Kingdomen
dc.contributor.institutionTheragen BiO Institute, B-dong, AICT Bldg, Iui-dong, Youngtong-gu, Suwon, 443-270, South Koreaen
dc.contributor.institutionInstitute for Biochemistry and Biology, Faculty for Mathematics and Natural Sciences, University of Potsdam, Karl-Liebknechtstraße 24-25, Potsdam Golm, 14476, Germanyen
dc.contributor.institutionDepartment of Biology, University of York, Wentworth Way, Heslington, York, YO10 5DD, United Kingdomen
dc.contributor.institutionGenomics Institute, Ulsan National Institute of Science and Technology, Ulsan, 689-798, South Koreaen
dc.contributor.institutionSchool of Archaeology and Earth Institute, University College Dublin, I-Dublin-4, Irelanden
kaust.authorEriksson, Andersen

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