Surface modification of promising cerium oxide nanoparticles for nanomedicine applications

Handle URI:
http://hdl.handle.net/10754/622476
Title:
Surface modification of promising cerium oxide nanoparticles for nanomedicine applications
Authors:
Nanda, Himansu Sekhar ( 0000-0001-5543-3565 )
Abstract:
Cerium oxide nanoparticles (CNPs) or nanoceria have emerged as a potential nanomedicine for the treatment of several diseases such as cancer. CNPs have a natural tendency to aggregate or agglomerate in their bare state, which leads to sedimentation in a biological environment. Since the natural biological environment is essentially aqueous, nanoparticle surface modification using suitable biocompatible hydrophilic chemical moieties is highly desirable to create effective aqueous dispersions. In this report, (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane was used as a functional, biocompatible organosilane to modify the surface of CNPs to produce promising nanoparticles which open substantial therapeutic avenues. The surface modified nanoparticles were produced in situ via an ammonia-induced ethylene glycol-assisted precipitation method and were characterized using complimentary characterization techniques. The interaction between the functional moiety and the nanoparticle was studied using powerful cross polarization/magic angle sample spinning solid state nuclear magnetic resonance spectroscopy. The surface-modified nanoparticles were extremely small and demonstrated a significant improvement in aqueous dispersibility. Moreover, the existence of a strong ionic coordination between the functional moiety and the surface of the nanoparticle was realised, indicating that the surface modified nanoceria are stable and that the nanoparticles should demonstrate an enhanced circulation time in a biological environment. The surface modification approach should be promising for the production of CNPs for nanomedicine applications. © The Royal Society of Chemistry.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
Nanda HS (2016) Surface modification of promising cerium oxide nanoparticles for nanomedicine applications. RSC Adv 6: 111889–111894. Available: http://dx.doi.org/10.1039/c6ra23046f.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
RSC Adv.
Issue Date:
14-Nov-2016
DOI:
10.1039/c6ra23046f
Type:
Article
ISSN:
2046-2069
Sponsors:
The author would like to acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), Saudi Arabia.
Additional Links:
http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C6RA23046F
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorNanda, Himansu Sekharen
dc.date.accessioned2017-01-02T09:28:33Z-
dc.date.available2017-01-02T09:28:33Z-
dc.date.issued2016-11-14en
dc.identifier.citationNanda HS (2016) Surface modification of promising cerium oxide nanoparticles for nanomedicine applications. RSC Adv 6: 111889–111894. Available: http://dx.doi.org/10.1039/c6ra23046f.en
dc.identifier.issn2046-2069en
dc.identifier.doi10.1039/c6ra23046fen
dc.identifier.urihttp://hdl.handle.net/10754/622476-
dc.description.abstractCerium oxide nanoparticles (CNPs) or nanoceria have emerged as a potential nanomedicine for the treatment of several diseases such as cancer. CNPs have a natural tendency to aggregate or agglomerate in their bare state, which leads to sedimentation in a biological environment. Since the natural biological environment is essentially aqueous, nanoparticle surface modification using suitable biocompatible hydrophilic chemical moieties is highly desirable to create effective aqueous dispersions. In this report, (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane was used as a functional, biocompatible organosilane to modify the surface of CNPs to produce promising nanoparticles which open substantial therapeutic avenues. The surface modified nanoparticles were produced in situ via an ammonia-induced ethylene glycol-assisted precipitation method and were characterized using complimentary characterization techniques. The interaction between the functional moiety and the nanoparticle was studied using powerful cross polarization/magic angle sample spinning solid state nuclear magnetic resonance spectroscopy. The surface-modified nanoparticles were extremely small and demonstrated a significant improvement in aqueous dispersibility. Moreover, the existence of a strong ionic coordination between the functional moiety and the surface of the nanoparticle was realised, indicating that the surface modified nanoceria are stable and that the nanoparticles should demonstrate an enhanced circulation time in a biological environment. The surface modification approach should be promising for the production of CNPs for nanomedicine applications. © The Royal Society of Chemistry.en
dc.description.sponsorshipThe author would like to acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), Saudi Arabia.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C6RA23046Fen
dc.titleSurface modification of promising cerium oxide nanoparticles for nanomedicine applicationsen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalRSC Adv.en
dc.contributor.institutionSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, Singaporeen
kaust.authorNanda, Himansu Sekharen
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