Silane-coated magnetic nanoparticles with surface thiol functions for conjugation with gold nanostars

Handle URI:
http://hdl.handle.net/10754/622464
Title:
Silane-coated magnetic nanoparticles with surface thiol functions for conjugation with gold nanostars
Authors:
Pallavicini, Piersandro; Cabrini, Elisa; Casu, Alberto; Dacarro, Giacomo; Antonio Diaz-Fernandez, Yuri; Falqui, Andrea ( 0000-0002-1476-7742 ) ; Milanese, Chiara; Vita, Francesco
Abstract:
Small (d ∼ 8 nm) magnetite nanoparticles, FeONP, are prepared and coated with mercaptopropyl trimethoxysilane (MPTS) to form FeONP@MPTS. In the coating step controlled MPTS/FeONP molar ratios are used, ranging from 1 to 7.8 × 10. The total quantity of MPTS per FeONP is determined by SEM-EDS analysis and the average number of free, reactive -SH groups per FeONP is calculated by a colorimetric method. At very low molar ratios MPTS forms a submonolayer on the FeONP surface with all -SH free to react, while on increasing the MPTS/FeONP molar ratio the (CHO)Si- groups of MPTS polymerize, forming a progressively thicker shell, in which only a small fraction of the -SH groups, positioned on the shell surface, is available for further reaction. The MPTS shell reduces the magnetic interactions occurring between the magnetite cores, lowering the occurrence and strength of collective magnetic states, with FeONP@MPTS showing the typical behaviour expected for a sample with a mono-modal size distribution of superparamagnetic nanoparticles. Interaction of FeONP@MPTS with gold nanostars (GNS) was tested, using both FeONP@MPTS with a MPTS submonolayer and with increasing shell thickness. Provided that a good balance is used between the number of available -SH and the overall size of FeONP@MPTS, the free thiols of such nanoparticles bind GNS decorating their surface, as shown by UV-Vis spectroscopy and TEM imaging.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Pallavicini P, Cabrini E, Casu A, Dacarro G, Antonio Diaz-Fernandez Y, et al. (2015) Silane-coated magnetic nanoparticles with surface thiol functions for conjugation with gold nanostars. Dalton Trans 44: 21088–21098. Available: http://dx.doi.org/10.1039/c5dt02812d.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Dalton Trans.
Issue Date:
10-Nov-2015
DOI:
10.1039/c5dt02812d
PubMed ID:
26594047
Type:
Article
ISSN:
1477-9226; 1477-9234
Sponsors:
We thank Fondazione Cariplo Milano, Italy (project 2010-0454), MIUR (PRIN 2010-2011, 20109P1MH2_003) and the University of Pavia (Fondo Ricerca Giovani) for funding.
Additional Links:
http://pubs.rsc.org/en/content/articlehtml/2015/dt/c5dt02812d
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorPallavicini, Piersandroen
dc.contributor.authorCabrini, Elisaen
dc.contributor.authorCasu, Albertoen
dc.contributor.authorDacarro, Giacomoen
dc.contributor.authorAntonio Diaz-Fernandez, Yurien
dc.contributor.authorFalqui, Andreaen
dc.contributor.authorMilanese, Chiaraen
dc.contributor.authorVita, Francescoen
dc.date.accessioned2017-01-02T09:28:32Z-
dc.date.available2017-01-02T09:28:32Z-
dc.date.issued2015-11-10en
dc.identifier.citationPallavicini P, Cabrini E, Casu A, Dacarro G, Antonio Diaz-Fernandez Y, et al. (2015) Silane-coated magnetic nanoparticles with surface thiol functions for conjugation with gold nanostars. Dalton Trans 44: 21088–21098. Available: http://dx.doi.org/10.1039/c5dt02812d.en
dc.identifier.issn1477-9226en
dc.identifier.issn1477-9234en
dc.identifier.pmid26594047en
dc.identifier.doi10.1039/c5dt02812den
dc.identifier.urihttp://hdl.handle.net/10754/622464-
dc.description.abstractSmall (d ∼ 8 nm) magnetite nanoparticles, FeONP, are prepared and coated with mercaptopropyl trimethoxysilane (MPTS) to form FeONP@MPTS. In the coating step controlled MPTS/FeONP molar ratios are used, ranging from 1 to 7.8 × 10. The total quantity of MPTS per FeONP is determined by SEM-EDS analysis and the average number of free, reactive -SH groups per FeONP is calculated by a colorimetric method. At very low molar ratios MPTS forms a submonolayer on the FeONP surface with all -SH free to react, while on increasing the MPTS/FeONP molar ratio the (CHO)Si- groups of MPTS polymerize, forming a progressively thicker shell, in which only a small fraction of the -SH groups, positioned on the shell surface, is available for further reaction. The MPTS shell reduces the magnetic interactions occurring between the magnetite cores, lowering the occurrence and strength of collective magnetic states, with FeONP@MPTS showing the typical behaviour expected for a sample with a mono-modal size distribution of superparamagnetic nanoparticles. Interaction of FeONP@MPTS with gold nanostars (GNS) was tested, using both FeONP@MPTS with a MPTS submonolayer and with increasing shell thickness. Provided that a good balance is used between the number of available -SH and the overall size of FeONP@MPTS, the free thiols of such nanoparticles bind GNS decorating their surface, as shown by UV-Vis spectroscopy and TEM imaging.en
dc.description.sponsorshipWe thank Fondazione Cariplo Milano, Italy (project 2010-0454), MIUR (PRIN 2010-2011, 20109P1MH2_003) and the University of Pavia (Fondo Ricerca Giovani) for funding.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.urlhttp://pubs.rsc.org/en/content/articlehtml/2015/dt/c5dt02812den
dc.titleSilane-coated magnetic nanoparticles with surface thiol functions for conjugation with gold nanostarsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalDalton Trans.en
dc.contributor.institutionDipartimento di Chimica, Università di Pavia, viale Taramelli 12, Pavia, 27100, Italyen
dc.contributor.institutionDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, United Kingdomen
dc.contributor.institutionDipartimento di Chimica, Università di Parma, Parco Area delle Scienze 17/A, Parma, 43124, Italyen
kaust.authorCasu, Albertoen
kaust.authorFalqui, Andreaen

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