A pulsed mode electrolytic drug delivery device

Handle URI:
http://hdl.handle.net/10754/622371
Title:
A pulsed mode electrolytic drug delivery device
Authors:
Yi, Ying; Buttner, Ulrich; Carreno, Armando Arpys Arevalo ( 0000-0001-9446-3310 ) ; Conchouso Gonzalez, David ( 0000-0002-9788-0977 ) ; Foulds, Ian G.
Abstract:
This paper reports the design of a proof-of-concept drug delivery device that is actuated using the bubbles formed during electrolysis. The device uses a platinum (Pt) coated nickel (Ni) metal foam and a solid drug in reservoir (SDR) approach to improve the device's performance. This electrochemically-driven pump has many features that are unlike conventional drug delivery devices: it is capable of pumping periodically and being refilled automatically; it features drug release control; and it enables targeted delivery. Pt-coated metal foam is used as a catalytic reforming element, which reduces the period of each delivery cycle. Two methods were used for fabricating the Pt-coated metal: sputtering and electroplating. Of these two methods, the sputtered Pt-coated metal foam has a higher pumping rate; it also has a comparable recombination rate when compared to the electroplated Pt-coated metal foam. The only drawback of this catalytic reformer is that it consumes nickel scaffold. Considering long-term applications, the electroplated Pt metal foam was selected for drug delivery, where a controlled drug release rate of 2.2 μg ± 0.3 μg per actuation pulse was achieved using 4 mW of power.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
Yi Y, Buttner U, Carreno AAA, Conchouso D, Foulds IG (2015) A pulsed mode electrolytic drug delivery device. Journal of Micromechanics and Microengineering 25: 105011. Available: http://dx.doi.org/10.1088/0960-1317/25/10/105011.
Publisher:
IOP Publishing
Journal:
Journal of Micromechanics and Microengineering
Issue Date:
14-Sep-2015
DOI:
10.1088/0960-1317/25/10/105011
Type:
Article
ISSN:
0960-1317; 1361-6439
Appears in Collections:
Articles; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYi, Yingen
dc.contributor.authorButtner, Ulrichen
dc.contributor.authorCarreno, Armando Arpys Arevaloen
dc.contributor.authorConchouso Gonzalez, Daviden
dc.contributor.authorFoulds, Ian G.en
dc.date.accessioned2017-01-02T09:28:27Z-
dc.date.available2017-01-02T09:28:27Z-
dc.date.issued2015-09-14en
dc.identifier.citationYi Y, Buttner U, Carreno AAA, Conchouso D, Foulds IG (2015) A pulsed mode electrolytic drug delivery device. Journal of Micromechanics and Microengineering 25: 105011. Available: http://dx.doi.org/10.1088/0960-1317/25/10/105011.en
dc.identifier.issn0960-1317en
dc.identifier.issn1361-6439en
dc.identifier.doi10.1088/0960-1317/25/10/105011en
dc.identifier.urihttp://hdl.handle.net/10754/622371-
dc.description.abstractThis paper reports the design of a proof-of-concept drug delivery device that is actuated using the bubbles formed during electrolysis. The device uses a platinum (Pt) coated nickel (Ni) metal foam and a solid drug in reservoir (SDR) approach to improve the device's performance. This electrochemically-driven pump has many features that are unlike conventional drug delivery devices: it is capable of pumping periodically and being refilled automatically; it features drug release control; and it enables targeted delivery. Pt-coated metal foam is used as a catalytic reforming element, which reduces the period of each delivery cycle. Two methods were used for fabricating the Pt-coated metal: sputtering and electroplating. Of these two methods, the sputtered Pt-coated metal foam has a higher pumping rate; it also has a comparable recombination rate when compared to the electroplated Pt-coated metal foam. The only drawback of this catalytic reformer is that it consumes nickel scaffold. Considering long-term applications, the electroplated Pt metal foam was selected for drug delivery, where a controlled drug release rate of 2.2 μg ± 0.3 μg per actuation pulse was achieved using 4 mW of power.en
dc.publisherIOP Publishingen
dc.subjectcatalytic reformeren
dc.subjectdrug deliveryen
dc.subjectelectrolytic pumpen
dc.subjectSDRen
dc.titleA pulsed mode electrolytic drug delivery deviceen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalJournal of Micromechanics and Microengineeringen
dc.contributor.institutionSchool of Engineering, University of British Columbia, Kelowna, BC, Canadaen
kaust.authorButtner, Ulrichen
kaust.authorCarreno, Armando Arpys Arevaloen
kaust.authorConchouso Gonzalez, Daviden
kaust.authorFoulds, Ian G.en
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