Whole genome sequence analysis of Mycobacterium suricattae

Handle URI:
http://hdl.handle.net/10754/622349
Title:
Whole genome sequence analysis of Mycobacterium suricattae
Authors:
Dippenaar, Anzaan; Parsons, Sven David Charles; Sampson, Samantha Leigh; Van Der Merwe, Ruben Gerhard; Drewe, Julian Ashley; Abdallah, Abdallah; Siame, Kabengele Keith; Gey Van Pittius, Nicolaas Claudius; Van Helden, Paul David; Pain, Arnab ( 0000-0002-1755-2819 ) ; Warren, Robin Mark
Abstract:
Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Pathogen Genomics Laboratory
Citation:
Dippenaar A, Parsons SDC, Sampson SL, van der Merwe RG, Drewe JA, et al. (2015) Whole genome sequence analysis of Mycobacterium suricattae. Tuberculosis 95: 682–688. Available: http://dx.doi.org/10.1016/j.tube.2015.10.001.
Publisher:
Elsevier BV
Journal:
Tuberculosis
Issue Date:
21-Oct-2015
DOI:
10.1016/j.tube.2015.10.001
PubMed ID:
26542221
Type:
Article
ISSN:
1472-9792
Sponsors:
This paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorDippenaar, Anzaanen
dc.contributor.authorParsons, Sven David Charlesen
dc.contributor.authorSampson, Samantha Leighen
dc.contributor.authorVan Der Merwe, Ruben Gerharden
dc.contributor.authorDrewe, Julian Ashleyen
dc.contributor.authorAbdallah, Abdallahen
dc.contributor.authorSiame, Kabengele Keithen
dc.contributor.authorGey Van Pittius, Nicolaas Claudiusen
dc.contributor.authorVan Helden, Paul Daviden
dc.contributor.authorPain, Arnaben
dc.contributor.authorWarren, Robin Marken
dc.date.accessioned2017-01-02T09:08:27Z-
dc.date.available2017-01-02T09:08:27Z-
dc.date.issued2015-10-21en
dc.identifier.citationDippenaar A, Parsons SDC, Sampson SL, van der Merwe RG, Drewe JA, et al. (2015) Whole genome sequence analysis of Mycobacterium suricattae. Tuberculosis 95: 682–688. Available: http://dx.doi.org/10.1016/j.tube.2015.10.001.en
dc.identifier.issn1472-9792en
dc.identifier.pmid26542221en
dc.identifier.doi10.1016/j.tube.2015.10.001en
dc.identifier.urihttp://hdl.handle.net/10754/622349-
dc.description.abstractTuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.en
dc.description.sponsorshipThis paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.en
dc.publisherElsevier BVen
dc.subjectHigh-throughput nucleotide sequencingen
dc.subjectMeerkaten
dc.subjectMycobacterium suricattaeen
dc.subjectTuberculosisen
dc.titleWhole genome sequence analysis of Mycobacterium suricattaeen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentPathogen Genomics Laboratoryen
dc.identifier.journalTuberculosisen
dc.contributor.institutionDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africaen
dc.contributor.institutionRoyal Veterinary College, London, United Kingdomen
kaust.authorAbdallah, Abdallahen
kaust.authorPain, Arnaben

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