Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones

Handle URI:
http://hdl.handle.net/10754/622311
Title:
Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones
Authors:
Ye, Min; Wen, Yuelu; Li, Huifang; Fu, Yejuan; Wang, Qinghao
Abstract:
A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
KAUST Department:
Laboratory for Computational and Theoretical Chemistry of Advanced Materials; Physical Sciences and Engineering (PSE) Division
Citation:
Ye M, Wen Y, Li H, Fu Y, Wang Q (2016) Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones. Tetrahedron Letters 57: 4983–4986. Available: http://dx.doi.org/10.1016/j.tetlet.2016.09.088.
Publisher:
Elsevier BV
Journal:
Tetrahedron Letters
Issue Date:
1-Oct-2016
DOI:
10.1016/j.tetlet.2016.09.088
Type:
Article
ISSN:
0040-4039
Sponsors:
The authors thank the NSFC (21202023) and the NSF of Jiangxi Provincial Education Department (GJJ151005 and GJJ14656) for financial support.
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0040403916312722
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYe, Minen
dc.contributor.authorWen, Yueluen
dc.contributor.authorLi, Huifangen
dc.contributor.authorFu, Yejuanen
dc.contributor.authorWang, Qinghaoen
dc.date.accessioned2017-01-02T09:08:25Z-
dc.date.available2017-01-02T09:08:25Z-
dc.date.issued2016-10-01en
dc.identifier.citationYe M, Wen Y, Li H, Fu Y, Wang Q (2016) Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones. Tetrahedron Letters 57: 4983–4986. Available: http://dx.doi.org/10.1016/j.tetlet.2016.09.088.en
dc.identifier.issn0040-4039en
dc.identifier.doi10.1016/j.tetlet.2016.09.088en
dc.identifier.urihttp://hdl.handle.net/10754/622311-
dc.description.abstractA highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipThe authors thank the NSFC (21202023) and the NSF of Jiangxi Provincial Education Department (GJJ151005 and GJJ14656) for financial support.en
dc.publisherElsevier BVen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0040403916312722en
dc.subjectMetal-freeen
dc.subjectHydrationen
dc.subjectHaloalkyneen
dc.subjectalpha-Halomethyl ketoneen
dc.subjectRegioselectivityen
dc.titleMetal-free hydration of aromatic haloalkynes to α-halomethyl ketonesen
dc.typeArticleen
dc.contributor.departmentLaboratory for Computational and Theoretical Chemistry of Advanced Materialsen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalTetrahedron Lettersen
dc.contributor.institutionKey Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi, Chinaen
kaust.authorLi, Huifangen
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