Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures

Handle URI:
http://hdl.handle.net/10754/622245
Title:
Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures
Authors:
Pahovnik, David; Hadjichristidis, Nikolaos ( 0000-0003-1442-1714 )
Abstract:
Different synthetic approaches utilizing ring-opening polymerization of N-carboxyanhydrides for preparation of polypeptide and polypeptide-based hybrid materials with various molecular architectures are described. An overview of polymerization mechanisms using conventional (various amines) as well as some recently developed initiators (hexamethyldisilazane, N-heterocyclic persistent carbenes, etc.) is presented, and their benefits and drawbacks for preparation of polypeptides with well-defined chain lengths and chain-end functionality are discussed. Recent examples from literature are used to illustrate different possibilities for synthesis of pure polypeptide materials with different molecular architectures bearing various functional groups, which are introduced either by modification of amino acids, before they are transformed into corresponding Ncarboxyanhydrides, or by post-polymerization modifications using protective groups and/or orthogonal functional groups. Different approaches for preparation of polypeptide-based hybrid materials are discussed as well using examples from recent literature. Syntheses of simple block copolymers or copolymers with more complex molecular architectures (graft and star copolymers) as well as modifications of nanoparticles and other surfaces with polypeptides are described.
KAUST Department:
KAUST Catalysis Center (KCC); Physical Sciences and Engineering (PSE) Division
Citation:
Pahovnik D, Hadjichristidis N (2015) Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures. Anionic Polymerization: 307–337. Available: http://dx.doi.org/10.1007/978-4-431-54186-8_6.
Publisher:
Springer Science + Business Media
Journal:
Anionic Polymerization
Issue Date:
1-Sep-2015
DOI:
10.1007/978-4-431-54186-8_6
Type:
Book Chapter
Appears in Collections:
Physical Sciences and Engineering (PSE) Division; KAUST Catalysis Center (KCC); Book Chapters

Full metadata record

DC FieldValue Language
dc.contributor.authorPahovnik, Daviden
dc.contributor.authorHadjichristidis, Nikolaosen
dc.date.accessioned2017-01-02T08:42:40Z-
dc.date.available2017-01-02T08:42:40Z-
dc.date.issued2015-09-01en
dc.identifier.citationPahovnik D, Hadjichristidis N (2015) Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures. Anionic Polymerization: 307–337. Available: http://dx.doi.org/10.1007/978-4-431-54186-8_6.en
dc.identifier.doi10.1007/978-4-431-54186-8_6en
dc.identifier.urihttp://hdl.handle.net/10754/622245-
dc.description.abstractDifferent synthetic approaches utilizing ring-opening polymerization of N-carboxyanhydrides for preparation of polypeptide and polypeptide-based hybrid materials with various molecular architectures are described. An overview of polymerization mechanisms using conventional (various amines) as well as some recently developed initiators (hexamethyldisilazane, N-heterocyclic persistent carbenes, etc.) is presented, and their benefits and drawbacks for preparation of polypeptides with well-defined chain lengths and chain-end functionality are discussed. Recent examples from literature are used to illustrate different possibilities for synthesis of pure polypeptide materials with different molecular architectures bearing various functional groups, which are introduced either by modification of amino acids, before they are transformed into corresponding Ncarboxyanhydrides, or by post-polymerization modifications using protective groups and/or orthogonal functional groups. Different approaches for preparation of polypeptide-based hybrid materials are discussed as well using examples from recent literature. Syntheses of simple block copolymers or copolymers with more complex molecular architectures (graft and star copolymers) as well as modifications of nanoparticles and other surfaces with polypeptides are described.en
dc.publisherSpringer Science + Business Mediaen
dc.subjectHybrid materialsen
dc.subjectMolecular architecturesen
dc.subjectN-carboxyanhydridesen
dc.subjectPolypeptidesen
dc.subjectRing-opening polymerizationen
dc.titleRing-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architecturesen
dc.typeBook Chapteren
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalAnionic Polymerizationen
kaust.authorPahovnik, Daviden
kaust.authorHadjichristidis, Nikolaosen
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