Lactate release from astrocytes to neurons contributes to cocaine memory formation

Handle URI:
http://hdl.handle.net/10754/622120
Title:
Lactate release from astrocytes to neurons contributes to cocaine memory formation
Authors:
Boury-Jamot, Benjamin; Halfon, Olivier; Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Boutrel, Benjamin
Abstract:
The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons actively interact in response of neuronal activity, but recent findings suggested that disrupting metabolic coupling may represent an innovative approach to prevent memory formation, in particular drug-related memories. Here, we review converging evidence illustrating how memory and addiction share neural circuitry and molecular mechanisms implicating lactate-mediated metabolic coupling between astrocytes and neurons. With several aspects of addiction depending on mnemonic processes elicited by drug experience, disrupting lactate transport involved in the formation of a pathological learning, linking the incentive, and motivational effects of drugs with drug-conditioned stimuli represent a promising approach to encourage abstinence.
KAUST Department:
King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia
Citation:
Boury-Jamot B, Halfon O, Magistretti PJ, Boutrel B (2016) Lactate release from astrocytes to neurons contributes to cocaine memory formation. BioEssays 38: 1266–1273. Available: http://dx.doi.org/10.1002/bies.201600118.
Publisher:
Wiley-Blackwell
Journal:
BioEssays
Issue Date:
12-Oct-2016
DOI:
10.1002/bies.201600118
Type:
Article
ISSN:
0265-9247
Sponsors:
The financial support of the NCCR Synapsy and the Préfargier Foundation is gratefully acknowledged. The authors thank Jessica Scheurer (graphic designer at Lausanne University Hospital) for assistance in the preparation of the figures.
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/bies.201600118/abstract
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBoury-Jamot, Benjaminen
dc.contributor.authorHalfon, Olivieren
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorBoutrel, Benjaminen
dc.date.accessioned2017-01-01T13:44:45Z-
dc.date.available2017-01-01T13:44:45Z-
dc.date.issued2016-10-12en
dc.identifier.citationBoury-Jamot B, Halfon O, Magistretti PJ, Boutrel B (2016) Lactate release from astrocytes to neurons contributes to cocaine memory formation. BioEssays 38: 1266–1273. Available: http://dx.doi.org/10.1002/bies.201600118.en
dc.identifier.issn0265-9247en
dc.identifier.doi10.1002/bies.201600118en
dc.identifier.urihttp://hdl.handle.net/10754/622120-
dc.description.abstractThe identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons actively interact in response of neuronal activity, but recent findings suggested that disrupting metabolic coupling may represent an innovative approach to prevent memory formation, in particular drug-related memories. Here, we review converging evidence illustrating how memory and addiction share neural circuitry and molecular mechanisms implicating lactate-mediated metabolic coupling between astrocytes and neurons. With several aspects of addiction depending on mnemonic processes elicited by drug experience, disrupting lactate transport involved in the formation of a pathological learning, linking the incentive, and motivational effects of drugs with drug-conditioned stimuli represent a promising approach to encourage abstinence.en
dc.description.sponsorshipThe financial support of the NCCR Synapsy and the Préfargier Foundation is gratefully acknowledged. The authors thank Jessica Scheurer (graphic designer at Lausanne University Hospital) for assistance in the preparation of the figures.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/bies.201600118/abstracten
dc.subjectastrocyteen
dc.subjectcocaineen
dc.subjectconditioningen
dc.subjectlactateen
dc.subjectmemoryen
dc.titleLactate release from astrocytes to neurons contributes to cocaine memory formationen
dc.typeArticleen
dc.contributor.departmentKing Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabiaen
dc.identifier.journalBioEssaysen
dc.contributor.institutionDepartment of Psychiatry, Centre for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerlanden
dc.contributor.institutionBrain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerlanden
dc.contributor.institutionDivision of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerlanden
kaust.authorMagistretti, Pierre J.en
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