Nanomembrane-Based, Thermal-Transport Biosensor for Living Cells

Handle URI:
http://hdl.handle.net/10754/622092
Title:
Nanomembrane-Based, Thermal-Transport Biosensor for Living Cells
Authors:
Elafandy, Rami T. ( 0000-0002-8529-2967 ) ; AbuElela, Ayman ( 0000-0002-4529-3156 ) ; Mishra, Pawan ( 0000-0001-9764-6016 ) ; Janjua, Bilal ( 0000-0001-9974-9879 ) ; Oubei, Hassan M. ( 0000-0001-6440-2488 ) ; Buttner, Ulrich; Majid, Mohammed Abdul ( 0000-0003-2224-8982 ) ; Ng, Tien Khee ( 0000-0002-1480-6975 ) ; Merzaban, Jasmeen S. ( 0000-0002-7276-2907 ) ; Ooi, Boon S. ( 0000-0001-9606-5578 )
Abstract:
Knowledge of materials' thermal-transport properties, conductivity and diffusivity, is crucial for several applications within areas of biology, material science and engineering. Specifically, a microsized, flexible, biologically integrated thermal transport sensor is beneficial to a plethora of applications, ranging across plants physiological ecology and thermal imaging and treatment of cancerous cells, to thermal dissipation in flexible semiconductors and thermoelectrics. Living cells pose extra challenges, due to their small volumes and irregular curvilinear shapes. Here a novel approach of simultaneously measuring thermal conductivity and diffusivity of different materials and its applicability to single cells is demonstrated. This technique is based on increasing phonon-boundary-scattering rate in nanomembranes, having extremely low flexural rigidities, to induce a considerable spectral dependence of the bandgap-emission over excitation-laser intensity. It is demonstrated that once in contact with organic or inorganic materials, the nanomembranes' emission spectrally shift based on the material's thermal diffusivity and conductivity. This NM-based technique is further applied to differentiate between different types and subtypes of cancer cells, based on their thermal-transport properties. It is anticipated that this novel technique to enable an efficient single-cell thermal targeting, allow better modeling of cellular thermal distribution and enable novel diagnostic techniques based on variations of single-cell thermal-transport properties.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Photonics Laboratory; Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
ElAfandy RT, AbuElela AF, Mishra P, Janjua B, Oubei HM, et al. (2016) Nanomembrane-Based, Thermal-Transport Biosensor for Living Cells. Small. Available: http://dx.doi.org/10.1002/smll.201603080.
Publisher:
Wiley-Blackwell
Journal:
Small
KAUST Grant Number:
BAS/1/1614-01- 01
Issue Date:
23-Nov-2016
DOI:
10.1002/smll.201603080
Type:
Article
ISSN:
1613-6810
Sponsors:
R.T.E. conceived, designed, and performed the experiments and numerical simulations and wrote the manuscript. A.F.A. prepared the living cells for measurements and edited the manuscript. P.M. and B.J. performed epitaxial growth of GaN wafers and edited the manuscript. U.B. assisted in experimental setup and approved the manuscript. H.O., M.A.M., T.K.N., and J.S.M. provided useful discussions on the project, discussed the results, and edited the manuscript. B.S.O. supervised the project, discussed the progress and results, and edited the manuscript. The authors acknowledge funding support from King Abdulaziz City for Science and Technology (KACST) Technology Innovation Center (TIC) for Solid State Lighting, grant no. KACST TIC R2-FP- 008, King Abdullah University of Science and Technology (KAUST) baseline funding, grant no. BAS/1/1614-01- 01.
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/smll.201603080/full
Appears in Collections:
Articles; Photonics Laboratory; Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorElafandy, Rami T.en
dc.contributor.authorAbuElela, Aymanen
dc.contributor.authorMishra, Pawanen
dc.contributor.authorJanjua, Bilalen
dc.contributor.authorOubei, Hassan M.en
dc.contributor.authorButtner, Ulrichen
dc.contributor.authorMajid, Mohammed Abdulen
dc.contributor.authorNg, Tien Kheeen
dc.contributor.authorMerzaban, Jasmeen S.en
dc.contributor.authorOoi, Boon S.en
dc.date.accessioned2016-12-29T13:20:21Z-
dc.date.available2016-12-29T13:20:21Z-
dc.date.issued2016-11-23en
dc.identifier.citationElAfandy RT, AbuElela AF, Mishra P, Janjua B, Oubei HM, et al. (2016) Nanomembrane-Based, Thermal-Transport Biosensor for Living Cells. Small. Available: http://dx.doi.org/10.1002/smll.201603080.en
dc.identifier.issn1613-6810en
dc.identifier.doi10.1002/smll.201603080en
dc.identifier.urihttp://hdl.handle.net/10754/622092-
dc.description.abstractKnowledge of materials' thermal-transport properties, conductivity and diffusivity, is crucial for several applications within areas of biology, material science and engineering. Specifically, a microsized, flexible, biologically integrated thermal transport sensor is beneficial to a plethora of applications, ranging across plants physiological ecology and thermal imaging and treatment of cancerous cells, to thermal dissipation in flexible semiconductors and thermoelectrics. Living cells pose extra challenges, due to their small volumes and irregular curvilinear shapes. Here a novel approach of simultaneously measuring thermal conductivity and diffusivity of different materials and its applicability to single cells is demonstrated. This technique is based on increasing phonon-boundary-scattering rate in nanomembranes, having extremely low flexural rigidities, to induce a considerable spectral dependence of the bandgap-emission over excitation-laser intensity. It is demonstrated that once in contact with organic or inorganic materials, the nanomembranes' emission spectrally shift based on the material's thermal diffusivity and conductivity. This NM-based technique is further applied to differentiate between different types and subtypes of cancer cells, based on their thermal-transport properties. It is anticipated that this novel technique to enable an efficient single-cell thermal targeting, allow better modeling of cellular thermal distribution and enable novel diagnostic techniques based on variations of single-cell thermal-transport properties.en
dc.description.sponsorshipR.T.E. conceived, designed, and performed the experiments and numerical simulations and wrote the manuscript. A.F.A. prepared the living cells for measurements and edited the manuscript. P.M. and B.J. performed epitaxial growth of GaN wafers and edited the manuscript. U.B. assisted in experimental setup and approved the manuscript. H.O., M.A.M., T.K.N., and J.S.M. provided useful discussions on the project, discussed the results, and edited the manuscript. B.S.O. supervised the project, discussed the progress and results, and edited the manuscript. The authors acknowledge funding support from King Abdulaziz City for Science and Technology (KACST) Technology Innovation Center (TIC) for Solid State Lighting, grant no. KACST TIC R2-FP- 008, King Abdullah University of Science and Technology (KAUST) baseline funding, grant no. BAS/1/1614-01- 01.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/smll.201603080/fullen
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCancer cellsen
dc.subjectGallium nitrideen
dc.subjectNanomembranesen
dc.subjectThermal biosensorsen
dc.subjectThermal conductivityen
dc.subjectThermal diffusivityen
dc.titleNanomembrane-Based, Thermal-Transport Biosensor for Living Cellsen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentPhotonics Laboratoryen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalSmallen
dc.eprint.versionPublisher's Version/PDFen
kaust.authorElafandy, Rami T.en
kaust.authorAbuElela, Aymanen
kaust.authorMishra, Pawanen
kaust.authorJanjua, Bilalen
kaust.authorOubei, Hassan M.en
kaust.authorButtner, Ulrichen
kaust.authorMajid, Mohammed Abdulen
kaust.authorNg, Tien Kheeen
kaust.authorMerzaban, Jasmeen S.en
kaust.authorOoi, Boon S.en
kaust.grant.numberBAS/1/1614-01- 01en
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