TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions

Handle URI:
http://hdl.handle.net/10754/622045
Title:
TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions
Authors:
Schmeier, Sebastian ( 0000-0002-3947-8226 ) ; Alam, Tanvir ( 0000-0003-4844-0171 ) ; Essack, Magbubah ( 0000-0003-2709-5356 ) ; Bajic, Vladimir B. ( 0000-0001-5435-4750 )
Abstract:
Transcription factors (TFs) play a pivotal role in transcriptional regulation, making them crucial for cell survival and important biological functions. For the regulation of transcription, interactions of different regulatory proteins known as transcription co-factors (TcoFs) and TFs are essential in forming necessary protein complexes. Although TcoFs themselves do not bind DNA directly, their influence on transcriptional regulation and initiation, although indirect, has been shown to be significant, with the functionality of TFs strongly influenced by the presence of TcoFs. In the TcoF-DB v2 database, we collect information on TcoFs. In this article, we describe updates and improvements implemented in TcoF-DB v2. TcoF-DB v2 provides several new features that enables exploration of the roles of TcoFs. The content of the database has significantly expanded, and is enriched with information from Gene Ontology, biological pathways, diseases and molecular signatures. TcoF-DB v2 now includes many more TFs; has substantially increased the number of human TcoFs to 958, and now includes information on mouse (418 new TcoFs). TcoF-DB v2 enables the exploration of information on TcoFs and allows investigations into their influence on transcriptional regulation in humans and mice. TcoF-DB v2 can be accessed at http://tcofdb.org/.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
Schmeier S, Alam T, Essack M, Bajic VB (2016) TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions. Nucleic Acids Research: gkw1007. Available: http://dx.doi.org/10.1093/nar/gkw1007.
Publisher:
Oxford University Press (OUP)
Journal:
Nucleic Acids Research
KAUST Grant Number:
URF/1/1976-02
Issue Date:
17-Oct-2016
DOI:
10.1093/nar/gkw1007
Type:
Article
ISSN:
0305-1048; 1362-4962
Sponsors:
King Abdullah University of Science and Technology (KAUST) base research fund (to T.A. and V.B.B.); KAUST Office of Sponsored Research (OSR) [URF/1/1976-02 to M.E.]. Funding for open access charge: KAUST.
Additional Links:
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkw1007
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorSchmeier, Sebastianen
dc.contributor.authorAlam, Tanviren
dc.contributor.authorEssack, Magbubahen
dc.contributor.authorBajic, Vladimir B.en
dc.date.accessioned2016-12-20T05:52:12Z-
dc.date.available2016-12-20T05:52:12Z-
dc.date.issued2016-10-17en
dc.identifier.citationSchmeier S, Alam T, Essack M, Bajic VB (2016) TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions. Nucleic Acids Research: gkw1007. Available: http://dx.doi.org/10.1093/nar/gkw1007.en
dc.identifier.issn0305-1048en
dc.identifier.issn1362-4962en
dc.identifier.doi10.1093/nar/gkw1007en
dc.identifier.urihttp://hdl.handle.net/10754/622045-
dc.description.abstractTranscription factors (TFs) play a pivotal role in transcriptional regulation, making them crucial for cell survival and important biological functions. For the regulation of transcription, interactions of different regulatory proteins known as transcription co-factors (TcoFs) and TFs are essential in forming necessary protein complexes. Although TcoFs themselves do not bind DNA directly, their influence on transcriptional regulation and initiation, although indirect, has been shown to be significant, with the functionality of TFs strongly influenced by the presence of TcoFs. In the TcoF-DB v2 database, we collect information on TcoFs. In this article, we describe updates and improvements implemented in TcoF-DB v2. TcoF-DB v2 provides several new features that enables exploration of the roles of TcoFs. The content of the database has significantly expanded, and is enriched with information from Gene Ontology, biological pathways, diseases and molecular signatures. TcoF-DB v2 now includes many more TFs; has substantially increased the number of human TcoFs to 958, and now includes information on mouse (418 new TcoFs). TcoF-DB v2 enables the exploration of information on TcoFs and allows investigations into their influence on transcriptional regulation in humans and mice. TcoF-DB v2 can be accessed at http://tcofdb.org/.en
dc.description.sponsorshipKing Abdullah University of Science and Technology (KAUST) base research fund (to T.A. and V.B.B.); KAUST Office of Sponsored Research (OSR) [URF/1/1976-02 to M.E.]. Funding for open access charge: KAUST.en
dc.publisherOxford University Press (OUP)en
dc.relation.urlhttps://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkw1007en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectgenesen
dc.subjectmandibulofacial dysostosisen
dc.subjectmiceen
dc.subjecttranscription factoren
dc.subjecttranscriptional controlen
dc.titleTcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactionsen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalNucleic Acids Researchen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionMassey University Auckland, Institute of Natural and Mathematical Sciences, Auckland, New Zealanden
kaust.authorAlam, Tanviren
kaust.authorEssack, Magbubahen
kaust.authorBajic, Vladimir B.en
kaust.grant.numberURF/1/1976-02en
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