Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

Handle URI:
http://hdl.handle.net/10754/621898
Title:
Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery
Authors:
Omar, Haneen; Croissant, Jonas G.; Alamoudi, Kholod; Alsaiari, Shahad K.; Alradwan, Ibrahim; Majrashi, Majed A.; Anjum, Dalaver H.; Martins, Patricia; Moosa, Basem ( 0000-0002-2350-4100 ) ; Almalik, Abdulaziz; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
The delivery of large cargos of diameter above 15 nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60 nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~ 534 kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Imaging and Characterization Core Lab
Citation:
Omar H, Croissant JG, Alamoudi K, Alsaiari S, Alradwan I, et al. (2016) Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery. Journal of Controlled Release. Available: http://dx.doi.org/10.1016/j.jconrel.2016.11.032.
Publisher:
Elsevier BV
Journal:
Journal of Controlled Release
Issue Date:
29-Nov-2016
DOI:
10.1016/j.jconrel.2016.11.032
Type:
Article
ISSN:
0168-3659
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0168365916312251
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorOmar, Haneenen
dc.contributor.authorCroissant, Jonas G.en
dc.contributor.authorAlamoudi, Kholoden
dc.contributor.authorAlsaiari, Shahad K.en
dc.contributor.authorAlradwan, Ibrahimen
dc.contributor.authorMajrashi, Majed A.en
dc.contributor.authorAnjum, Dalaver H.en
dc.contributor.authorMartins, Patriciaen
dc.contributor.authorMoosa, Basemen
dc.contributor.authorAlmalik, Abdulazizen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2016-11-30T08:43:10Z-
dc.date.available2016-11-30T08:43:10Z-
dc.date.issued2016-11-29en
dc.identifier.citationOmar H, Croissant JG, Alamoudi K, Alsaiari S, Alradwan I, et al. (2016) Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery. Journal of Controlled Release. Available: http://dx.doi.org/10.1016/j.jconrel.2016.11.032.en
dc.identifier.issn0168-3659en
dc.identifier.doi10.1016/j.jconrel.2016.11.032en
dc.identifier.urihttp://hdl.handle.net/10754/621898-
dc.description.abstractThe delivery of large cargos of diameter above 15 nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60 nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~ 534 kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications.en
dc.publisherElsevier BVen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0168365916312251en
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Journal of Controlled Release. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Controlled Release, 29 November 2016. DOI: 10.1016/j.jconrel.2016.11.032en
dc.subjectsilica nanoparticlesen
dc.subjectmagnetic nanoparticlesen
dc.subjectprotein deliveryen
dc.subjectbiodegradable nanoparticlesen
dc.subjectpH triggered deliveryen
dc.titleBiodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Deliveryen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentImaging and Characterization Core Laben
dc.identifier.journalJournal of Controlled Releaseen
dc.eprint.versionPost-printen
dc.contributor.institutionLife sciences and Environment Research Institute, Center of Excellence in Nanomedicine (CENM), King Abdulaziz City for Science and Technology (KACST), Riyadh 11461, Saudi Arabiaen
kaust.authorOmar, Haneenen
kaust.authorCroissant, Jonas G.en
kaust.authorAlamoudi, Kholoden
kaust.authorAlsaiari, Shahad K.en
kaust.authorAnjum, Dalaver H.en
kaust.authorMartins, Patriciaen
kaust.authorMoosa, Basemen
kaust.authorKhashab, Niveen M.en
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