Near-Infrared Intraoperative Chemiluminescence Imaging

Handle URI:
http://hdl.handle.net/10754/621683
Title:
Near-Infrared Intraoperative Chemiluminescence Imaging
Authors:
Büchel, Gabriel E. ( 0000-0002-5055-7099 ) ; Carney, Brandon; Shaffer, Travis M.; Tang, Jun; Austin, Christine; Arora, Manish; Zeglis, Brian M.; Grimm, Jan; Eppinger, Jorg ( 0000-0001-7886-7059 ) ; Reiner, Thomas ( 0000-0002-7819-5480 )
Abstract:
Intraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near-infrared light upon exposure to an aqueous solution of Ce4+ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9pmolcm-2 of the transition-metal-based ICI agent. As a proof of concept, we use ICI for the invivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal-to-noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
KAUST Department:
KAUST Catalysis Center (KCC)
Citation:
Büchel GE, Carney B, Shaffer TM, Tang J, Austin C, et al. (2016) Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem 11: 1978–1982. Available: http://dx.doi.org/10.1002/cmdc.201600301.
Publisher:
Wiley-Blackwell
Journal:
ChemMedChem
Issue Date:
3-Aug-2016
DOI:
10.1002/cmdc.201600301
Type:
Article
ISSN:
1860-7179
Sponsors:
King Abdullah University of Science and Technology; US National Institutes of Health (NIH)[P30 CA008748-48, R01CA183953, R01A183953, 4R00A178205-02, K25 EB016673, R01EB014944, R21 CA191679]; MSKCC Center for Molecular Imaging and Nanotechnology; Tow Foundation; MSKCC Experimental Therapeutics Center; National Science Foundation Integrative Graduate Education and Research Traineeship[IGERT 0965983]
Appears in Collections:
Articles; KAUST Catalysis Center (KCC)

Full metadata record

DC FieldValue Language
dc.contributor.authorBüchel, Gabriel E.en
dc.contributor.authorCarney, Brandonen
dc.contributor.authorShaffer, Travis M.en
dc.contributor.authorTang, Junen
dc.contributor.authorAustin, Christineen
dc.contributor.authorArora, Manishen
dc.contributor.authorZeglis, Brian M.en
dc.contributor.authorGrimm, Janen
dc.contributor.authorEppinger, Jorgen
dc.contributor.authorReiner, Thomasen
dc.date.accessioned2016-11-03T13:22:41Z-
dc.date.available2016-11-03T13:22:41Z-
dc.date.issued2016-08-03en
dc.identifier.citationBüchel GE, Carney B, Shaffer TM, Tang J, Austin C, et al. (2016) Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem 11: 1978–1982. Available: http://dx.doi.org/10.1002/cmdc.201600301.en
dc.identifier.issn1860-7179en
dc.identifier.doi10.1002/cmdc.201600301en
dc.identifier.urihttp://hdl.handle.net/10754/621683-
dc.description.abstractIntraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near-infrared light upon exposure to an aqueous solution of Ce4+ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9pmolcm-2 of the transition-metal-based ICI agent. As a proof of concept, we use ICI for the invivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal-to-noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.description.sponsorshipKing Abdullah University of Science and Technologyen
dc.description.sponsorshipUS National Institutes of Health (NIH)[P30 CA008748-48, R01CA183953, R01A183953, 4R00A178205-02, K25 EB016673, R01EB014944, R21 CA191679]en
dc.description.sponsorshipMSKCC Center for Molecular Imaging and Nanotechnologyen
dc.description.sponsorshipTow Foundationen
dc.description.sponsorshipMSKCC Experimental Therapeutics Centeren
dc.description.sponsorshipNational Science Foundation Integrative Graduate Education and Research Traineeship[IGERT 0965983]en
dc.publisherWiley-Blackwellen
dc.subjectChemiluminescenceen
dc.titleNear-Infrared Intraoperative Chemiluminescence Imagingen
dc.typeArticleen
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.identifier.journalChemMedChemen
dc.contributor.institutionDepartment of Radiology; Memorial Sloan Kettering Cancer Center; New York NY 10065 USAen
dc.contributor.institutionDepartment of Chemistry; Hunter College and PhD Program in Chemistry; The Graduate Center of the; City University of New York; New York NY 10018 USAen
dc.contributor.institutionMolecular Pharmacology Program; Memorial Sloan Kettering Cancer Center; 1275 York Avenue New York NY 10065 USAen
dc.contributor.institutionDepartment of Preventive Medicine; Icahn School of Medicine at Mount Sinai; New York NY 10029 USAen
dc.contributor.institutionDepartment of Radiology; Weill Cornell Medical College; New York NY 10065 USAen
dc.contributor.institutionProgram of Pharmacology; Weill Cornell Medical College; New York NY 10065 USAen
kaust.authorBüchel, Gabriel E.en
kaust.authorEppinger, Jorgen
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