Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells

Handle URI:
http://hdl.handle.net/10754/621675
Title:
Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells
Authors:
Croissant, Jonas G.; Fatieiev, Yevhen; Omar, Haneen; Anjum, Dalaver H.; Gurinov, Andrei; Lu, Jie; Tamanoi, Fuyuhiko; Zink, Jeffrey I.; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Despite the worldwide interest generated by periodic mesoporous organosilica (PMO) bulk materials, the design of PMO nanomaterials with controlled morphology remains largely unexplored and their properties unknown. In this work, we describe the first study of PMO nanoparticles (NPs) based on meta-phenylene bridges, and we conducted a comparative structure–property relationship investigation with para-phenylene-bridged PMO NPs. Our findings indicate that the change of the isomer drastically affects the structure, morphology, size, porosity and thermal stability of PMO materials. We observed a much higher porosity and thermal stability of the para-based PMO which was likely due to a higher molecular periodicity. Additionally, the para isomer could generate multipodal NPs at very low stirring speed and upon this discovery we designed a phenylene–ethylene bridged PMO with a controlled Janus morphology. Unprecedentedly high payloads could be obtained from 40 to 110 wt % regardless of the organic bridge of PMOs. Finally, we demonstrate for the first time the co-delivery of two cargos by PMO NPs. Importantly, the cargo stability in PMOs did not require the capping of the pores, unlike pure silica, and the delivery could be autonomously triggered in cancer cells by acidic pH with nearly 70 % cell killing. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab; Imaging and Characterization Core Lab
Citation:
Croissant JG, Fatieiev Y, Omar H, Anjum DH, Gurinov A, et al. (2016) Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells. Chem Eur J 22: 9607–9615. Available: http://dx.doi.org/10.1002/chem.201600587.
Publisher:
Wiley-Blackwell
Journal:
Chemistry - A European Journal
Issue Date:
1-Jun-2016
DOI:
10.1002/chem.201600587
Type:
Article
ISSN:
0947-6539
Sponsors:
We gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST), and NSF Grant DBI-1266377.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorCroissant, Jonas G.en
dc.contributor.authorFatieiev, Yevhenen
dc.contributor.authorOmar, Haneenen
dc.contributor.authorAnjum, Dalaver H.en
dc.contributor.authorGurinov, Andreien
dc.contributor.authorLu, Jieen
dc.contributor.authorTamanoi, Fuyuhikoen
dc.contributor.authorZink, Jeffrey I.en
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2016-11-03T13:22:30Z-
dc.date.available2016-11-03T13:22:30Z-
dc.date.issued2016-06-01en
dc.identifier.citationCroissant JG, Fatieiev Y, Omar H, Anjum DH, Gurinov A, et al. (2016) Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells. Chem Eur J 22: 9607–9615. Available: http://dx.doi.org/10.1002/chem.201600587.en
dc.identifier.issn0947-6539en
dc.identifier.doi10.1002/chem.201600587en
dc.identifier.urihttp://hdl.handle.net/10754/621675-
dc.description.abstractDespite the worldwide interest generated by periodic mesoporous organosilica (PMO) bulk materials, the design of PMO nanomaterials with controlled morphology remains largely unexplored and their properties unknown. In this work, we describe the first study of PMO nanoparticles (NPs) based on meta-phenylene bridges, and we conducted a comparative structure–property relationship investigation with para-phenylene-bridged PMO NPs. Our findings indicate that the change of the isomer drastically affects the structure, morphology, size, porosity and thermal stability of PMO materials. We observed a much higher porosity and thermal stability of the para-based PMO which was likely due to a higher molecular periodicity. Additionally, the para isomer could generate multipodal NPs at very low stirring speed and upon this discovery we designed a phenylene–ethylene bridged PMO with a controlled Janus morphology. Unprecedentedly high payloads could be obtained from 40 to 110 wt % regardless of the organic bridge of PMOs. Finally, we demonstrate for the first time the co-delivery of two cargos by PMO NPs. Importantly, the cargo stability in PMOs did not require the capping of the pores, unlike pure silica, and the delivery could be autonomously triggered in cancer cells by acidic pH with nearly 70 % cell killing. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen
dc.description.sponsorshipWe gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST), and NSF Grant DBI-1266377.en
dc.publisherWiley-Blackwellen
dc.subjectBridged silsesquioxanesen
dc.titlePeriodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cellsen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentImaging and Characterization Core Laben
dc.identifier.journalChemistry - A European Journalen
dc.contributor.institutionDepartment of Chemistry and Biochemistry; California NanoSystems Institute; Jonsson Comprehensive Cancer Center; University of California Los Angeles; Los Angeles California USAen
dc.contributor.institutionDepartment of Microbiology; Immunology and Molecular Genetics; California NanoSystems Institute; Jonsson Comprehensive Cancer Center; University of California Los Angeles; Los Angeles California USAen
kaust.authorCroissant, Jonas G.en
kaust.authorFatieiev, Yevhenen
kaust.authorOmar, Haneenen
kaust.authorAnjum, Dalaver H.en
kaust.authorGurinov, Andreien
kaust.authorKhashab, Niveen M.en
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