Chloroplasts activity and PAP-signaling regulate programmed cell death in Arabidopsis

Handle URI:
http://hdl.handle.net/10754/621468
Title:
Chloroplasts activity and PAP-signaling regulate programmed cell death in Arabidopsis
Authors:
Bruggeman, Quentin; Mazubert, Christelle; Prunier, Florence; Lugan, Raphael; Chan, Kai Xun; Phua, Su Yin; Pogson, Barry J.; Krieger-Liszkay, Anja; Delarue, Marianne; Benhamed, Moussa ( 0000-0002-4181-1702 ) ; Bergounioux, Catherine; Raynaud, Cécile
Abstract:
Programmed cell death (PCD) is a crucial process both for plant development and responses to biotic and abiotic stress. There is accumulating evidence that chloroplasts may play a central role during plant PCD as for mitochondria in animal cells, but it is still unclear whether they participate in PCD onset, execution, or both. To tackle this question, we have analyzed the contribution of chloroplast function to the cell death phenotype of the myoinositol phosphate synthase1 (mips1) mutant that forms spontaneous lesions in a light-dependent manner. We show that photosynthetically active chloroplasts are required for PCD to occur in mips1, but this process is independent of the redox state of the chloroplast. Systematic genetic analyses with retrograde signaling mutants reveal that 3’-phosphoadenosine 5’-phosphate, a chloroplast retrograde signal that modulates nuclear gene expression in response to stress, can inhibit cell death and compromises plant innate immunity via inhibition of the RNA-processing 5’-3’ exoribonucleases. Our results provide evidence for the role of chloroplast-derived signal and RNA metabolism in the control of cell death and biotic stress response. © 2016 American Society of Plant Biologists. All Rights Reserved.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Center for Desert Agriculture
Citation:
Bruggeman Q, Mazubert C, Prunier F, Lugan R, Chan KX, et al. (2016) Chloroplasts activity and PAP-signaling regulate programmed cell death in Arabidopsis. Plant Physiol: pp.01872.2015. Available: http://dx.doi.org/10.1104/pp.15.01872.
Publisher:
American Society of Plant Biologists (ASPB)
Journal:
Plant Physiology
Issue Date:
9-Jan-2016
DOI:
10.1104/pp.15.01872
Type:
Article
ISSN:
0032-0889; 1532-2548
Sponsors:
This work was supported by the Agence Nationale de la Recherche (grant nos. ANR 2010 JCJC1207 01 and MAPK-IPS ANR-2010-BLAN-1613-02).
Appears in Collections:
Articles; Center for Desert Agriculture; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBruggeman, Quentinen
dc.contributor.authorMazubert, Christelleen
dc.contributor.authorPrunier, Florenceen
dc.contributor.authorLugan, Raphaelen
dc.contributor.authorChan, Kai Xunen
dc.contributor.authorPhua, Su Yinen
dc.contributor.authorPogson, Barry J.en
dc.contributor.authorKrieger-Liszkay, Anjaen
dc.contributor.authorDelarue, Marianneen
dc.contributor.authorBenhamed, Moussaen
dc.contributor.authorBergounioux, Catherineen
dc.contributor.authorRaynaud, Cécileen
dc.date.accessioned2016-11-03T08:30:04Z-
dc.date.available2016-11-03T08:30:04Z-
dc.date.issued2016-01-09en
dc.identifier.citationBruggeman Q, Mazubert C, Prunier F, Lugan R, Chan KX, et al. (2016) Chloroplasts activity and PAP-signaling regulate programmed cell death in Arabidopsis. Plant Physiol: pp.01872.2015. Available: http://dx.doi.org/10.1104/pp.15.01872.en
dc.identifier.issn0032-0889en
dc.identifier.issn1532-2548en
dc.identifier.doi10.1104/pp.15.01872en
dc.identifier.urihttp://hdl.handle.net/10754/621468-
dc.description.abstractProgrammed cell death (PCD) is a crucial process both for plant development and responses to biotic and abiotic stress. There is accumulating evidence that chloroplasts may play a central role during plant PCD as for mitochondria in animal cells, but it is still unclear whether they participate in PCD onset, execution, or both. To tackle this question, we have analyzed the contribution of chloroplast function to the cell death phenotype of the myoinositol phosphate synthase1 (mips1) mutant that forms spontaneous lesions in a light-dependent manner. We show that photosynthetically active chloroplasts are required for PCD to occur in mips1, but this process is independent of the redox state of the chloroplast. Systematic genetic analyses with retrograde signaling mutants reveal that 3’-phosphoadenosine 5’-phosphate, a chloroplast retrograde signal that modulates nuclear gene expression in response to stress, can inhibit cell death and compromises plant innate immunity via inhibition of the RNA-processing 5’-3’ exoribonucleases. Our results provide evidence for the role of chloroplast-derived signal and RNA metabolism in the control of cell death and biotic stress response. © 2016 American Society of Plant Biologists. All Rights Reserved.en
dc.description.sponsorshipThis work was supported by the Agence Nationale de la Recherche (grant nos. ANR 2010 JCJC1207 01 and MAPK-IPS ANR-2010-BLAN-1613-02).en
dc.publisherAmerican Society of Plant Biologists (ASPB)en
dc.titleChloroplasts activity and PAP-signaling regulate programmed cell death in Arabidopsisen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentCenter for Desert Agricultureen
dc.identifier.journalPlant Physiologyen
dc.contributor.institutionInstitute of Plant Sciences Paris-Saclay (IPS2), UMR 9213/UMR1403, CNRS, INRA, Université Paris-Sud, Université d’Evry, Université Paris-Diderot, Sorbonne Paris-Cité, Bâtiment 630, Orsay, Franceen
dc.contributor.institutionCNRS UMR 7205, Muséum National d’Histoire Naturelle, CP50, 45 rue Buffon, Paris, Franceen
dc.contributor.institutionInstitut de Biologie Moléculaire des Plantes, Unité Propre de Recherche 2357 CNRS, Université de Strasbourg, 12 rue du Général Zimmer, Strasbourg cedex, Franceen
dc.contributor.institutionLaboratoire de Physiologie des Fruits et Légumes, Université d’Avignon et des Pays du Vaucluse, Bat. Agrosciences, Avignon cedex 9, Franceen
dc.contributor.institutionAustralian Research Council Centre of Excellence in Plant Energy Biology, Research School of Biology, Australian National University, Acton, ACT, Australiaen
dc.contributor.institutionInstitute for Integrative Biology of the Cell (I2BC), Commissariat à l’Energie Atomique et aux Energies Alternatives Saclay, Centre National de la Recherche Scientifique, Université Paris-Sud, Gif-sur-Yvette cedex, Franceen
kaust.authorBenhamed, Moussaen
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