Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure

Handle URI:
http://hdl.handle.net/10754/621441
Title:
Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure
Authors:
Baud, Maxime O.; Parafita, Julia; Nguyen, Audrey; Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Petit, Jean-Marie
Abstract:
© 2016 European Sleep Research Society. Sleep is viewed as a fundamental restorative function of the brain, but its specific role in neural energy budget remains poorly understood. Sleep deprivation dampens brain energy metabolism and impairs cognitive functions. Intriguingly, sleep fragmentation, despite normal total sleep duration, has a similar cognitive impact, and in this paper we ask the question of whether it may also impair brain energy metabolism. To this end, we used a recently developed mouse model of 2 weeks of sleep fragmentation and measured 2-deoxy-glucose uptake and glycogen, glucose and lactate concentration in different brain regions. In order to homogenize mice behaviour during metabolic measurements, we exposed them to a novel environment for 1 h. Using an intra-hippocampal electrode, we first showed that hippocampal electroencephalograph (EEG) response to exploration was unaltered by 1 or 14 days of sleep fragmentation. However, after 14 days, sleep fragmented mice exhibited a lower uptake of 2-deoxy-glucose in cortex and hippocampus and lower cortical lactate levels than control mice. Our results suggest that long-term sleep fragmentation impaired brain metabolism to a similar extent as total sleep deprivation without affecting the neuronal responsiveness of hippocampus to a novel environment.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Baud MO, Parafita J, Nguyen A, Magistretti PJ, Petit J-M (2016) Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure. Journal of Sleep Research 25: 583–590. Available: http://dx.doi.org/10.1111/jsr.12419.
Publisher:
Wiley-Blackwell
Journal:
Journal of Sleep Research
Issue Date:
3-May-2016
DOI:
10.1111/jsr.12419
Type:
Article
ISSN:
0962-1105
Sponsors:
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung[323600-119351/1, 3100AO-108336/1]
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBaud, Maxime O.en
dc.contributor.authorParafita, Juliaen
dc.contributor.authorNguyen, Audreyen
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorPetit, Jean-Marieen
dc.date.accessioned2016-11-03T08:29:24Z-
dc.date.available2016-11-03T08:29:24Z-
dc.date.issued2016-05-03en
dc.identifier.citationBaud MO, Parafita J, Nguyen A, Magistretti PJ, Petit J-M (2016) Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure. Journal of Sleep Research 25: 583–590. Available: http://dx.doi.org/10.1111/jsr.12419.en
dc.identifier.issn0962-1105en
dc.identifier.doi10.1111/jsr.12419en
dc.identifier.urihttp://hdl.handle.net/10754/621441-
dc.description.abstract© 2016 European Sleep Research Society. Sleep is viewed as a fundamental restorative function of the brain, but its specific role in neural energy budget remains poorly understood. Sleep deprivation dampens brain energy metabolism and impairs cognitive functions. Intriguingly, sleep fragmentation, despite normal total sleep duration, has a similar cognitive impact, and in this paper we ask the question of whether it may also impair brain energy metabolism. To this end, we used a recently developed mouse model of 2 weeks of sleep fragmentation and measured 2-deoxy-glucose uptake and glycogen, glucose and lactate concentration in different brain regions. In order to homogenize mice behaviour during metabolic measurements, we exposed them to a novel environment for 1 h. Using an intra-hippocampal electrode, we first showed that hippocampal electroencephalograph (EEG) response to exploration was unaltered by 1 or 14 days of sleep fragmentation. However, after 14 days, sleep fragmented mice exhibited a lower uptake of 2-deoxy-glucose in cortex and hippocampus and lower cortical lactate levels than control mice. Our results suggest that long-term sleep fragmentation impaired brain metabolism to a similar extent as total sleep deprivation without affecting the neuronal responsiveness of hippocampus to a novel environment.en
dc.description.sponsorshipSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung[323600-119351/1, 3100AO-108336/1]en
dc.publisherWiley-Blackwellen
dc.subjectAstrocyte-neurone lactate shuttleen
dc.subjectBeta rhythmen
dc.subjectEnergy metabolismen
dc.subjectExploratory behavioren
dc.subjectNeurometabolic couplingen
dc.titleSleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposureen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalJournal of Sleep Researchen
dc.contributor.institutionLNDC; Brain Mind Institute; Faculté des Sciences de la Vie; Ecole Polytechnique Fédérale de Lausanne (EPFL); Lausanne Switzerlanden
dc.contributor.institutionDepartment of Neurology; UCSF; San Francisco CA USAen
dc.contributor.institutionCentre de Neurosciences Psychiatriques; Centre Hospitalier Universitaire Vaudois (CHUV); Prilly Switzerlanden
kaust.authorMagistretti, Pierre J.en
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