Sodium signaling and astrocyte energy metabolism

Handle URI:
http://hdl.handle.net/10754/621415
Title:
Sodium signaling and astrocyte energy metabolism
Authors:
Chatton, Jean-Yves; Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Barros, L. Felipe
Abstract:
The Na+ gradient across the plasma membrane is constantly exploited by astrocytes as a secondary energy source to regulate the intracellular and extracellular milieu, and discard waste products. One of the most prominent roles of astrocytes in the brain is the Na+-dependent clearance of glutamate released by neurons during synaptic transmission. The intracellular Na+ load collectively generated by these processes converges at the Na,K-ATPase pump, responsible for Na+ extrusion from the cell, which is achieved at the expense of cellular ATP. These processes represent pivotal mechanisms enabling astrocytes to increase the local availability of metabolic substrates in response to neuronal activity. This review presents basic principles linking the intracellular handling of Na+ following activity-related transmembrane fluxes in astrocytes and the energy metabolic pathways involved. We propose a role of Na+ as an energy currency and as a mediator of metabolic signals in the context of neuron-glia interactions. We further discuss the possible impact of the astrocytic syncytium for the distribution and coordination of the metabolic response, and the compartmentation of these processes in cellular microdomains and subcellular organelles. Finally, we illustrate future avenues of investigation into signaling mechanisms aimed at bridging the gap between Na+ and the metabolic machinery. © 2016 Wiley Periodicals, Inc.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program
Citation:
Chatton J-Y, Magistretti PJ, Barros LF (2016) Sodium signaling and astrocyte energy metabolism. Glia 64: 1667–1676. Available: http://dx.doi.org/10.1002/glia.22971.
Publisher:
Wiley-Blackwell
Journal:
Glia
Issue Date:
31-Mar-2016
DOI:
10.1002/glia.22971
Type:
Article
ISSN:
0894-1491
Sponsors:
Comisión Nacional de Investigación Científica y Tecnológica; Fondecyt[1130095]
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/glia.22971/full
Appears in Collections:
Articles; Bioscience Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorChatton, Jean-Yvesen
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorBarros, L. Felipeen
dc.date.accessioned2016-11-03T08:28:47Z-
dc.date.available2016-11-03T08:28:47Z-
dc.date.issued2016-03-31en
dc.identifier.citationChatton J-Y, Magistretti PJ, Barros LF (2016) Sodium signaling and astrocyte energy metabolism. Glia 64: 1667–1676. Available: http://dx.doi.org/10.1002/glia.22971.en
dc.identifier.issn0894-1491en
dc.identifier.doi10.1002/glia.22971en
dc.identifier.urihttp://hdl.handle.net/10754/621415-
dc.description.abstractThe Na+ gradient across the plasma membrane is constantly exploited by astrocytes as a secondary energy source to regulate the intracellular and extracellular milieu, and discard waste products. One of the most prominent roles of astrocytes in the brain is the Na+-dependent clearance of glutamate released by neurons during synaptic transmission. The intracellular Na+ load collectively generated by these processes converges at the Na,K-ATPase pump, responsible for Na+ extrusion from the cell, which is achieved at the expense of cellular ATP. These processes represent pivotal mechanisms enabling astrocytes to increase the local availability of metabolic substrates in response to neuronal activity. This review presents basic principles linking the intracellular handling of Na+ following activity-related transmembrane fluxes in astrocytes and the energy metabolic pathways involved. We propose a role of Na+ as an energy currency and as a mediator of metabolic signals in the context of neuron-glia interactions. We further discuss the possible impact of the astrocytic syncytium for the distribution and coordination of the metabolic response, and the compartmentation of these processes in cellular microdomains and subcellular organelles. Finally, we illustrate future avenues of investigation into signaling mechanisms aimed at bridging the gap between Na+ and the metabolic machinery. © 2016 Wiley Periodicals, Inc.en
dc.description.sponsorshipComisión Nacional de Investigación Científica y Tecnológicaen
dc.description.sponsorshipFondecyt[1130095]en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/glia.22971/fullen
dc.subjectGlycolysisen
dc.subjectLactateen
dc.subjectMembrane transporten
dc.subjectMitochondriaen
dc.subjectNa,K-ATPaseen
dc.subjectNeuron-glia interactionsen
dc.subjectSyncytiumen
dc.titleSodium signaling and astrocyte energy metabolismen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.identifier.journalGliaen
dc.contributor.institutionDepartment of Fundamental Neurosciences; University of Lausanne; Rue Du Bugnon 9 Lausanne Switzerlanden
dc.contributor.institutionBrain Mind Institute, Ecole Polytechnique Fédérale De Lausanne (EPFL); Lausanne Switzerlanden
dc.contributor.institutionCentro De Estudios Científicos; Valdivia Chileen
kaust.authorMagistretti, Pierre J.en
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.