Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis

Handle URI:
http://hdl.handle.net/10754/621384
Title:
Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis
Authors:
Caputo, Fanny; De Nicola, Milena; Sienkiewicz, Andrzej; Giovanetti, Anna; Bejarano, Ignacio; Licoccia, Silvia; Traversa, Enrico ( 0000-0001-6336-941X ) ; Ghibelli, Lina
Abstract:
Efficient inorganic UV shields, mostly based on refracting TiO2 particles, have dramatically changed the sun exposure habits. Unfortunately, health concerns have emerged from the pro-oxidant photocatalytic effect of UV-irradiated TiO2, which mediates toxic effects on cells. Therefore, improvements in cosmetic solar shield technology are a strong priority. CeO2 nanoparticles are not only UV refractors but also potent biological antioxidants due to the surface 3+/4+ valency switch, which confers anti-inflammatory, anti-ageing and therapeutic properties. Herein, UV irradiation protocols were set up, allowing selective study of the extra-shielding effects of CeO2vs. TiO2 nanoparticles on reporter cells. TiO2 irradiated with UV (especially UVA) exerted strong photocatalytic effects, superimposing their pro-oxidant, cell-damaging and mutagenic action when induced by UV, thereby worsening the UV toxicity. On the contrary, irradiated CeO2 nanoparticles, via their Ce3+/Ce4+ redox couple, exerted impressive protection on UV-treated cells, by buffering oxidation, preserving viability and proliferation, reducing DNA damage and accelerating repair; strikingly, they almost eliminated mutagenesis, thus acting as an important tool to prevent skin cancer. Interestingly, CeO2 nanoparticles also protect cells from the damage induced by irradiated TiO2, suggesting that these two particles may also complement their effects in solar lotions. CeO2 nanoparticles, which intrinsically couple UV shielding with biological and genetic protection, appear to be ideal candidates for next-generation sun shields. © The Royal Society of Chemistry 2015.
KAUST Department:
King Abdullah University, Science and Technology, Thuwal, Saudi Arabia
Citation:
Caputo F, De Nicola M, Sienkiewicz A, Giovanetti A, Bejarano I, et al. (2015) Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis. Nanoscale 7: 15643–15656. Available: http://dx.doi.org/10.1039/c5nr03767k.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale
Issue Date:
20-Aug-2015
DOI:
10.1039/c5nr03767k
PubMed ID:
26349675
Type:
Article
ISSN:
2040-3364; 2040-3372
Sponsors:
F.C. and M.D.N. are recipient of fellowships from the PhD school in Materials for Health, Energy and Environment, Universita di Roma Tor Vergata. We wish to thank Dr Vittoria Maresca, Ospedale S. Gallicano (Roma, Italy), and Prof. Giampiero Gualandi, Universita La Tuscia (Viterbo, Italy) for invaluable support. Thanks are due to Prof. Francesco Stellacci and Dr Marta Mameli, Ecole Polytechnique Federal de Lausanne (EPFL, Lausanne, Switzerland), for invaluable discussions and support. We thank Dr Dalaver H. Anjum, King Abdullah University of Science and Technology (KAUST, Thuwal, Saudi Arabia) for assistance in TEM observations; Ms Marianeve Polimeno and Ms Monica Maio (Dipartimento di Biologia, Universita di Roma Tor Vergata) are acknowledged for the experiments with HaCat cells.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCaputo, Fannyen
dc.contributor.authorDe Nicola, Milenaen
dc.contributor.authorSienkiewicz, Andrzejen
dc.contributor.authorGiovanetti, Annaen
dc.contributor.authorBejarano, Ignacioen
dc.contributor.authorLicoccia, Silviaen
dc.contributor.authorTraversa, Enricoen
dc.contributor.authorGhibelli, Linaen
dc.date.accessioned2016-11-03T08:28:02Z-
dc.date.available2016-11-03T08:28:02Z-
dc.date.issued2015-08-20en
dc.identifier.citationCaputo F, De Nicola M, Sienkiewicz A, Giovanetti A, Bejarano I, et al. (2015) Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis. Nanoscale 7: 15643–15656. Available: http://dx.doi.org/10.1039/c5nr03767k.en
dc.identifier.issn2040-3364en
dc.identifier.issn2040-3372en
dc.identifier.pmid26349675en
dc.identifier.doi10.1039/c5nr03767ken
dc.identifier.urihttp://hdl.handle.net/10754/621384-
dc.description.abstractEfficient inorganic UV shields, mostly based on refracting TiO2 particles, have dramatically changed the sun exposure habits. Unfortunately, health concerns have emerged from the pro-oxidant photocatalytic effect of UV-irradiated TiO2, which mediates toxic effects on cells. Therefore, improvements in cosmetic solar shield technology are a strong priority. CeO2 nanoparticles are not only UV refractors but also potent biological antioxidants due to the surface 3+/4+ valency switch, which confers anti-inflammatory, anti-ageing and therapeutic properties. Herein, UV irradiation protocols were set up, allowing selective study of the extra-shielding effects of CeO2vs. TiO2 nanoparticles on reporter cells. TiO2 irradiated with UV (especially UVA) exerted strong photocatalytic effects, superimposing their pro-oxidant, cell-damaging and mutagenic action when induced by UV, thereby worsening the UV toxicity. On the contrary, irradiated CeO2 nanoparticles, via their Ce3+/Ce4+ redox couple, exerted impressive protection on UV-treated cells, by buffering oxidation, preserving viability and proliferation, reducing DNA damage and accelerating repair; strikingly, they almost eliminated mutagenesis, thus acting as an important tool to prevent skin cancer. Interestingly, CeO2 nanoparticles also protect cells from the damage induced by irradiated TiO2, suggesting that these two particles may also complement their effects in solar lotions. CeO2 nanoparticles, which intrinsically couple UV shielding with biological and genetic protection, appear to be ideal candidates for next-generation sun shields. © The Royal Society of Chemistry 2015.en
dc.description.sponsorshipF.C. and M.D.N. are recipient of fellowships from the PhD school in Materials for Health, Energy and Environment, Universita di Roma Tor Vergata. We wish to thank Dr Vittoria Maresca, Ospedale S. Gallicano (Roma, Italy), and Prof. Giampiero Gualandi, Universita La Tuscia (Viterbo, Italy) for invaluable support. Thanks are due to Prof. Francesco Stellacci and Dr Marta Mameli, Ecole Polytechnique Federal de Lausanne (EPFL, Lausanne, Switzerland), for invaluable discussions and support. We thank Dr Dalaver H. Anjum, King Abdullah University of Science and Technology (KAUST, Thuwal, Saudi Arabia) for assistance in TEM observations; Ms Marianeve Polimeno and Ms Monica Maio (Dipartimento di Biologia, Universita di Roma Tor Vergata) are acknowledged for the experiments with HaCat cells.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleCerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesisen
dc.typeArticleen
dc.contributor.departmentKing Abdullah University, Science and Technology, Thuwal, Saudi Arabiaen
dc.identifier.journalNanoscaleen
dc.contributor.institutionDipartimento di Biologia, Università di Roma Tor Vergata, Roma, Italyen
dc.contributor.institutionDipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Roma, Italyen
dc.contributor.institutionInstitute of Physics of Complex Matter, Faculty of Basic Sciences, École Polytechnique Fédéral de Lausanne, Lausanne, Switzerlanden
dc.contributor.institutionUTBIORAD, ENEA, Roma, Italyen
kaust.authorBejarano, Ignacioen
kaust.authorTraversa, Enricoen

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