Sensors and Instrumentation towards early detection of osteoporosis

Handle URI:
http://hdl.handle.net/10754/621291
Title:
Sensors and Instrumentation towards early detection of osteoporosis
Authors:
Afsarimanesh, Nasrin; Mukhopadhyay, Subhas C; Kruger, Marlena; Yu, Pak-Lam; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems. © 2016 IEEE.
KAUST Department:
King Abdullah University of Science and Technology, Saudi Arabia
Citation:
Afsarimanesh N, Mukhopadhyay SC, Kruger M, Yu P-L, Kosel J (2016) Sensors and Instrumentation towards early detection of osteoporosis. 2016 IEEE International Instrumentation and Measurement Technology Conference Proceedings. Available: http://dx.doi.org/10.1109/I2MTC.2016.7520573.
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
2016 IEEE International Instrumentation and Measurement Technology Conference Proceedings
Conference/Event name:
2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016
Issue Date:
27-Jul-2016
DOI:
10.1109/I2MTC.2016.7520573
Type:
Conference Paper
Appears in Collections:
Conference Papers

Full metadata record

DC FieldValue Language
dc.contributor.authorAfsarimanesh, Nasrinen
dc.contributor.authorMukhopadhyay, Subhas Cen
dc.contributor.authorKruger, Marlenaen
dc.contributor.authorYu, Pak-Lamen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2016-11-03T06:56:59Z-
dc.date.available2016-11-03T06:56:59Z-
dc.date.issued2016-07-27en
dc.identifier.citationAfsarimanesh N, Mukhopadhyay SC, Kruger M, Yu P-L, Kosel J (2016) Sensors and Instrumentation towards early detection of osteoporosis. 2016 IEEE International Instrumentation and Measurement Technology Conference Proceedings. Available: http://dx.doi.org/10.1109/I2MTC.2016.7520573.en
dc.identifier.doi10.1109/I2MTC.2016.7520573en
dc.identifier.urihttp://hdl.handle.net/10754/621291-
dc.description.abstractA label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems. © 2016 IEEE.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.subjectComplex Non-linear Least Square (CNLS)en
dc.titleSensors and Instrumentation towards early detection of osteoporosisen
dc.typeConference Paperen
dc.contributor.departmentKing Abdullah University of Science and Technology, Saudi Arabiaen
dc.identifier.journal2016 IEEE International Instrumentation and Measurement Technology Conference Proceedingsen
dc.conference.date23 May 2016 through 26 May 2016en
dc.conference.name2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016en
dc.contributor.institutionSchool of Engineering and Advanced Technology, Massey University, Palmerston North, New Zealanden
dc.contributor.institutionInstitute of Food Science and Technology, Massey University, Palmerston North, New Zealanden
kaust.authorKosel, Jürgenen
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