Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (hiv)

Handle URI:
http://hdl.handle.net/10754/620515
Title:
Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (hiv)
Authors:
O'Rourke, Aubrie ( 0000-0003-1277-9536 ) ; Kremb, Stephan; Voolstra, Christian R. ( 0000-0003-4555-3795 )
Assignee:
King Abdullah University Of Science And Technology
Abstract:
Anti-viral compounds with low cytotoxicity are identified from screening of products found in Red Sea sponges, including the sponge Stylissa carteri. The identified compounds can be brominated pyrrole-2- aminoimidazole alkaloids and derivatives thereof. Specific examples of identified compounds include oroidin, hymenialdisine, and debromohymenialdisine, as well as derivatives thereof. The compounds also can be useful scaffolds or pharmacores for further chemical modification and derivatization. Selected compounds, particularly oroidin, show selective anti-viral HIV-1 activity coupled with reduced cytotoxicity. The compounds can function as HIV reverse-transcriptase inhibitors, and molecular modeling can be used to confirm inhibition.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Issue Date:
6-May-2016
Submitted date:
2014-10-26
Type:
Patent
Application Number:
WO 2016067090 A1
Patent Status:
Published Application
Additional Links:
http://www.google.com/patents/WO2016067090A1; http://worldwide.espacenet.com/publicationDetails/biblio?CC=WO&NR=2016067090A1&KC=A1&FT=D
Appears in Collections:
Patents

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Rourke, Aubrieen
dc.contributor.authorKremb, Stephanen
dc.contributor.authorVoolstra, Christian R.en
dc.date.accessioned2016-09-19T10:35:56Z-
dc.date.available2016-09-19T10:35:56Z-
dc.date.issued2016-05-06-
dc.date.submitted2014-10-26-
dc.identifier.urihttp://hdl.handle.net/10754/620515-
dc.description.abstractAnti-viral compounds with low cytotoxicity are identified from screening of products found in Red Sea sponges, including the sponge Stylissa carteri. The identified compounds can be brominated pyrrole-2- aminoimidazole alkaloids and derivatives thereof. Specific examples of identified compounds include oroidin, hymenialdisine, and debromohymenialdisine, as well as derivatives thereof. The compounds also can be useful scaffolds or pharmacores for further chemical modification and derivatization. Selected compounds, particularly oroidin, show selective anti-viral HIV-1 activity coupled with reduced cytotoxicity. The compounds can function as HIV reverse-transcriptase inhibitors, and molecular modeling can be used to confirm inhibition.en
dc.relation.urlhttp://www.google.com/patents/WO2016067090A1en
dc.relation.urlhttp://worldwide.espacenet.com/publicationDetails/biblio?CC=WO&NR=2016067090A1&KC=A1&FT=Den
dc.titleAlkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (hiv)en
dc.typePatenten
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.description.statusPublished Applicationen
dc.contributor.assigneeKing Abdullah University Of Science And Technologyen
dc.description.countryWorld Intellectual Property Organization (WIPO)en
dc.identifier.applicationnumberWO 2016067090 A1en
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