Review of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers of psychiatric disorders

Handle URI:
http://hdl.handle.net/10754/618208
Title:
Review of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers of psychiatric disorders
Authors:
Marquet, Pierre; Depeursinge, Christian; Magistretti, Pierre J. ( 0000-0002-6678-320X )
Abstract:
Quantitative phase microscopy (QPM) has recently emerged as a new powerful quantitative imaging technique well suited to noninvasively explore a transparent specimen with a nanometric axial sensitivity. In this review, we expose the recent developments of quantitative phase-digital holographic microscopy (QP-DHM). Quantitative phase-digital holographic microscopy (QP-DHM) represents an important and efficient quantitative phase method to explore cell structure and dynamics. In a second part, the most relevant QPM applications in the field of cell biology are summarized. A particular emphasis is placed on the original biological information, which can be derived from the quantitative phase signal. In a third part, recent applications obtained, with QP-DHM in the field of cellular neuroscience, namely the possibility to optically resolve neuronal network activity and spine dynamics, are presented. Furthermore, potential applications of QPM related to psychiatry through the identification of new and original cell biomarkers that, when combined with a range of other biomarkers, could significantly contribute to the determination of high risk developmental trajectories for psychiatric disorders, are discussed.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Review of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers of psychiatric disorders 2014, 1 (2):020901 Neurophotonics
Publisher:
SPIE-Intl Soc Optical Eng
Journal:
Neurophotonics
Issue Date:
22-Sep-2014
DOI:
10.1117/1.NPh.1.2.020901
Type:
Article
ISSN:
2329-423X
Sponsors:
The work presented in this review is the result of a close collaboration between the microvision and microdiagnosis group (SCI/STI/CHD group) of EPFL with Florian Charrière, Jonas Kühn, Nicolas Pavillon, Etienne Shafer, Fatih Toy, Yann Cotte, the Laboratory of Neuroenergetics and Cellular Dynamics, Brain and Mind Institute of EPFL with Benjamin Rappaz, Pascal Jourdain, the Center for Psychiatric neuroscience, CHUV with Daniel Boss, Kaspar Rothefusser and the company Lyncée Tec SA, Lausanne (http://www.lynceetec.com). We thank the Swiss National Science Foundation (SNSF) Grant No. CR3213_132993 the National Center of competence in research Synapsy (http://www.nccr-synapsy.ch/) as well as the fondation de Préfargier.
Additional Links:
http://neurophotonics.spiedigitallibrary.org/article.aspx?doi=10.1117/1.NPh.1.2.020901
Appears in Collections:
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Full metadata record

DC FieldValue Language
dc.contributor.authorMarquet, Pierreen
dc.contributor.authorDepeursinge, Christianen
dc.contributor.authorMagistretti, Pierre J.en
dc.date.accessioned2016-08-10T12:06:51Z-
dc.date.available2016-08-10T12:06:51Z-
dc.date.issued2014-09-22-
dc.identifier.citationReview of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers of psychiatric disorders 2014, 1 (2):020901 Neurophotonicsen
dc.identifier.issn2329-423X-
dc.identifier.doi10.1117/1.NPh.1.2.020901-
dc.identifier.urihttp://hdl.handle.net/10754/618208-
dc.description.abstractQuantitative phase microscopy (QPM) has recently emerged as a new powerful quantitative imaging technique well suited to noninvasively explore a transparent specimen with a nanometric axial sensitivity. In this review, we expose the recent developments of quantitative phase-digital holographic microscopy (QP-DHM). Quantitative phase-digital holographic microscopy (QP-DHM) represents an important and efficient quantitative phase method to explore cell structure and dynamics. In a second part, the most relevant QPM applications in the field of cell biology are summarized. A particular emphasis is placed on the original biological information, which can be derived from the quantitative phase signal. In a third part, recent applications obtained, with QP-DHM in the field of cellular neuroscience, namely the possibility to optically resolve neuronal network activity and spine dynamics, are presented. Furthermore, potential applications of QPM related to psychiatry through the identification of new and original cell biomarkers that, when combined with a range of other biomarkers, could significantly contribute to the determination of high risk developmental trajectories for psychiatric disorders, are discussed.en
dc.description.sponsorshipThe work presented in this review is the result of a close collaboration between the microvision and microdiagnosis group (SCI/STI/CHD group) of EPFL with Florian Charrière, Jonas Kühn, Nicolas Pavillon, Etienne Shafer, Fatih Toy, Yann Cotte, the Laboratory of Neuroenergetics and Cellular Dynamics, Brain and Mind Institute of EPFL with Benjamin Rappaz, Pascal Jourdain, the Center for Psychiatric neuroscience, CHUV with Daniel Boss, Kaspar Rothefusser and the company Lyncée Tec SA, Lausanne (http://www.lynceetec.com). We thank the Swiss National Science Foundation (SNSF) Grant No. CR3213_132993 the National Center of competence in research Synapsy (http://www.nccr-synapsy.ch/) as well as the fondation de Préfargier.en
dc.language.isoenen
dc.publisherSPIE-Intl Soc Optical Engen
dc.relation.urlhttp://neurophotonics.spiedigitallibrary.org/article.aspx?doi=10.1117/1.NPh.1.2.020901en
dc.rightsArchived with thanks to Neurophotonicsen
dc.titleReview of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers of psychiatric disordersen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalNeurophotonicsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionCentre Hospitalier Universitaire Vaudois (CHUV), Centre de Neurosciences Psychiatriques, Département de Psychiatrie, Site de Cery, Prilly/Lausanne CH-1008, Switzerlanden
dc.contributor.institutionBrain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerlanden
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorDepeursinge, Christianen
kaust.authorMagistretti, Pierre J.en
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