Oxidative stress signaling to chromatin in health and disease

Handle URI:
http://hdl.handle.net/10754/617554
Title:
Oxidative stress signaling to chromatin in health and disease
Authors:
Kreuz, Sarah; Fischle, Wolfgang ( 0000-0002-2335-8932 )
Abstract:
Oxidative stress has a significant impact on the development and progression of common human pathologies, including cancer, diabetes, hypertension and neurodegenerative diseases. Increasing evidence suggests that oxidative stress globally influences chromatin structure, DNA methylation, enzymatic and non-enzymatic post-translational modifications of histones and DNA-binding proteins. The effects of oxidative stress on these chromatin alterations mediate a number of cellular changes, including modulation of gene expression, cell death, cell survival and mutagenesis, which are disease-driving mechanisms in human pathologies. Targeting oxidative stress-dependent pathways is thus a promising strategy for the prevention and treatment of these diseases. We summarize recent research developments connecting oxidative stress and chromatin regulation.
KAUST Department:
Environmental Epigenetics Program
Citation:
Oxidative stress signaling to chromatin in health and disease 2016, 8 (6):843 Epigenomics
Publisher:
Future Medicine Ltd
Journal:
Epigenomics
Issue Date:
20-Jun-2016
DOI:
10.2217/epi-2016-0002
Type:
Article
ISSN:
1750-1911; 1750-192X
Sponsors:
The research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Additional Links:
http://www.futuremedicine.com/doi/10.2217/epi-2016-0002
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorKreuz, Sarahen
dc.contributor.authorFischle, Wolfgangen
dc.date.accessioned2016-07-26T09:29:53Z-
dc.date.available2016-07-26T09:29:53Z-
dc.date.issued2016-06-20-
dc.identifier.citationOxidative stress signaling to chromatin in health and disease 2016, 8 (6):843 Epigenomicsen
dc.identifier.issn1750-1911-
dc.identifier.issn1750-192X-
dc.identifier.doi10.2217/epi-2016-0002-
dc.identifier.urihttp://hdl.handle.net/10754/617554-
dc.description.abstractOxidative stress has a significant impact on the development and progression of common human pathologies, including cancer, diabetes, hypertension and neurodegenerative diseases. Increasing evidence suggests that oxidative stress globally influences chromatin structure, DNA methylation, enzymatic and non-enzymatic post-translational modifications of histones and DNA-binding proteins. The effects of oxidative stress on these chromatin alterations mediate a number of cellular changes, including modulation of gene expression, cell death, cell survival and mutagenesis, which are disease-driving mechanisms in human pathologies. Targeting oxidative stress-dependent pathways is thus a promising strategy for the prevention and treatment of these diseases. We summarize recent research developments connecting oxidative stress and chromatin regulation.en
dc.description.sponsorshipThe research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.en
dc.language.isoenen
dc.publisherFuture Medicine Ltden
dc.relation.urlhttp://www.futuremedicine.com/doi/10.2217/epi-2016-0002en
dc.rightsThis work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleOxidative stress signaling to chromatin in health and diseaseen
dc.typeArticleen
dc.contributor.departmentEnvironmental Epigenetics Programen
dc.identifier.journalEpigenomicsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorKreuz, Sarahen
kaust.authorFischle, Wolfgangen
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