Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species

Handle URI:
http://hdl.handle.net/10754/617088
Title:
Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species
Authors:
Ansari, Hifzur Rahman ( 0000-0002-0646-1743 ) ; Templeton, Thomas J.; Subudhi, Amit Kumar; Ramaprasad, Abhinay ( 0000-0001-9372-5526 ) ; Tang, Jianxia; Lu, Feng; Naeem, Raeece ( 0000-0003-1734-1007 ) ; Hashish, Yasmeen ( 0000-0002-9855-1139 ) ; Oguike, Mary C.; Benavente, Ernest Diez; Clark, Taane G.; Sutherland, Colin J.; Barnwell, John W.; Culleton, Richard; Cao, Jun; Pain, Arnab ( 0000-0002-1755-2819 )
Abstract:
Malaria in humans is caused by six species of Plasmodium parasites, of which the nuclear genome sequences for the two Plasmodium ovale spp., P. ovale curtisi and P. ovale wallikeri, and Plasmodium malariae have not yet been analyzed. Here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. Plasmodium ovale curtisi and P. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric ranges through the tropics of Africa, Asia and Oceania. Both P. ovale spp. show expansion of the surfin variant gene family, and an amplification of the Plasmodium interspersed repeat (pir) superfamily which results in an approximately 30% increase in genome size. For comparison, we have also analyzed the draft nuclear genome of P. malariae, a malaria parasite causing mild malaria symptoms with a quartan life cycle, long-term chronic infections, and wide geographic distribution. Plasmodium malariae shows only a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family. The observed diversity in the P. ovale wallikeri and P. ovale curtisi surface antigens, combined with their phylogenetic separation, supports consideration that the two parasites be given species status.
KAUST Department:
Pathogen Genomics Laboratory; Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species 2016 International Journal for Parasitology
Publisher:
Elsevier BV
Journal:
International Journal for Parasitology
Issue Date:
5-Jul-2016
DOI:
10.1016/j.ijpara.2016.05.009
Type:
Article
ISSN:
00207519
Sponsors:
TJT was supported by a visiting professorship to the Institute of Tropical Medicine, Nagasaki University, Japan. JC was supported by grants from the National Natural Science Foundation of China (No. 81271870) and the National Natural Science Foundation of Jiangsu Province, China (No. BK20150001). AP is supported by faculty baseline funding from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia and the Global Institute for Collaborative Research and Education (GI-CoRE) at the Center for Disease Control, Hokkaido University, Japan. RC is supported by Japanese Society of Parasitology (JSPS), Japan Grant-in-Aid for Scientific Research Nos. 24255009, 25870525 and 16K21233. MCO, EDB, TGC and CJS are supported by UK Medical Research Council Project Grant MR/L008661/1 to CJS. The authors thank the staff of the Bioscience Core Laboratory in KAUST for sequencing the DNA libraries. Osamu Kaneko is thanked for discussions and critical reading of the manuscript.
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0020751916301357
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DC FieldValue Language
dc.contributor.authorAnsari, Hifzur Rahmanen
dc.contributor.authorTempleton, Thomas J.en
dc.contributor.authorSubudhi, Amit Kumaren
dc.contributor.authorRamaprasad, Abhinayen
dc.contributor.authorTang, Jianxiaen
dc.contributor.authorLu, Fengen
dc.contributor.authorNaeem, Raeeceen
dc.contributor.authorHashish, Yasmeenen
dc.contributor.authorOguike, Mary C.en
dc.contributor.authorBenavente, Ernest Diezen
dc.contributor.authorClark, Taane G.en
dc.contributor.authorSutherland, Colin J.en
dc.contributor.authorBarnwell, John W.en
dc.contributor.authorCulleton, Richarden
dc.contributor.authorCao, Junen
dc.contributor.authorPain, Arnaben
dc.date.accessioned2016-07-18T09:21:07Z-
dc.date.available2016-07-18T09:21:07Z-
dc.date.issued2016-07-05-
dc.identifier.citationGenome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species 2016 International Journal for Parasitologyen
dc.identifier.issn00207519-
dc.identifier.doi10.1016/j.ijpara.2016.05.009-
dc.identifier.urihttp://hdl.handle.net/10754/617088-
dc.description.abstractMalaria in humans is caused by six species of Plasmodium parasites, of which the nuclear genome sequences for the two Plasmodium ovale spp., P. ovale curtisi and P. ovale wallikeri, and Plasmodium malariae have not yet been analyzed. Here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. Plasmodium ovale curtisi and P. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric ranges through the tropics of Africa, Asia and Oceania. Both P. ovale spp. show expansion of the surfin variant gene family, and an amplification of the Plasmodium interspersed repeat (pir) superfamily which results in an approximately 30% increase in genome size. For comparison, we have also analyzed the draft nuclear genome of P. malariae, a malaria parasite causing mild malaria symptoms with a quartan life cycle, long-term chronic infections, and wide geographic distribution. Plasmodium malariae shows only a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family. The observed diversity in the P. ovale wallikeri and P. ovale curtisi surface antigens, combined with their phylogenetic separation, supports consideration that the two parasites be given species status.en
dc.description.sponsorshipTJT was supported by a visiting professorship to the Institute of Tropical Medicine, Nagasaki University, Japan. JC was supported by grants from the National Natural Science Foundation of China (No. 81271870) and the National Natural Science Foundation of Jiangsu Province, China (No. BK20150001). AP is supported by faculty baseline funding from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia and the Global Institute for Collaborative Research and Education (GI-CoRE) at the Center for Disease Control, Hokkaido University, Japan. RC is supported by Japanese Society of Parasitology (JSPS), Japan Grant-in-Aid for Scientific Research Nos. 24255009, 25870525 and 16K21233. MCO, EDB, TGC and CJS are supported by UK Medical Research Council Project Grant MR/L008661/1 to CJS. The authors thank the staff of the Bioscience Core Laboratory in KAUST for sequencing the DNA libraries. Osamu Kaneko is thanked for discussions and critical reading of the manuscript.en
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0020751916301357en
dc.rightsArchived with thanks to International Journal for Parasitology. Under a Creative Commons license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPlasmodium ovale spp.en
dc.subjectPlasmodium ovale wallikerien
dc.subjectPlasmodium ovale curtisien
dc.subjectPlasmodium malariaeen
dc.subjectPIRen
dc.subjectSURFINen
dc.subjectRBP-2en
dc.subjectP25/27en
dc.titleGenome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium speciesen
dc.typeArticleen
dc.contributor.departmentPathogen Genomics Laboratoryen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalInternational Journal for Parasitologyen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japanen
dc.contributor.institutionDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York 10021, USAen
dc.contributor.institutionKey Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, People’s Republic of Chinaen
dc.contributor.institutionDepartment of Immunology & Infection, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdomen
dc.contributor.institutionDepartment of Pathogen Molecular Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdomen
dc.contributor.institutionDepartment of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdomen
dc.contributor.institutionPublic Health England Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine, London, United Kingdomen
dc.contributor.institutionCenters for Disease Control and Prevention, Atlanta, GA 30329-4027, USAen
dc.contributor.institutionMalaria Unit, Department of Pathology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japanen
dc.contributor.institutionGlobal Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo 001-0020, Japanen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorRahman Ansari, Hifzuren
kaust.authorSubudhi, Amit Kumaren
kaust.authorRamaprasad, Abhinayen
kaust.authorNaeem, Raeeceen
kaust.authorHashish, Yasmeenen
kaust.authorPain, Arnaben
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