A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

Handle URI:
http://hdl.handle.net/10754/615927
Title:
A “twisted” microfluidic mixer suitable for a wide range of flow rate applications
Authors:
Sivashankar, Shilpa; Agambayev, Sumeyra; Mashraei, Yousof; Li, Erqiang ( 0000-0002-5003-0756 ) ; Thoroddsen, Sigurdur T. ( 0000-0001-6997-4311 ) ; Salama, Khaled N. ( 0000-0001-7742-1282 )
Abstract:
This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.
KAUST Department:
Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division; Physical Sciences and Engineering (PSE) Division
Citation:
A “twisted” microfluidic mixer suitable for a wide range of flow rate applications 2016, 10 (3):034120 Biomicrofluidics
Publisher:
AIP Publishing
Journal:
Biomicrofluidics
Issue Date:
27-Jun-2016
DOI:
10.1063/1.4954812
Type:
Article
ISSN:
1932-1058
Sponsors:
The authors would like to thank David Conchoso and Armando Arpys Arevalo Carreno for providing insights on fluid dynamics and the simulation environment. Shilpa Sivashankar designed and administered the experiments, collected and interpreted the data, and wrote the manuscript. Sumeyra Agambayev performed the experiments and carried out calculations. Yousof Mashraei simulated the mixer design and analyzed the simulation results. Sigurdur Thoroddsen designed, and Erqiang Li performed some of the experiments to observe the type of flow within the micro channels. Khaled Nabil Salama supervised the research, provided conceptual advice on the experiments conducted and detail review of the manuscript.
Additional Links:
http://scitation.aip.org/content/aip/journal/bmf/10/3/10.1063/1.4954812
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSivashankar, Shilpaen
dc.contributor.authorAgambayev, Sumeyraen
dc.contributor.authorMashraei, Yousofen
dc.contributor.authorLi, Erqiangen
dc.contributor.authorThoroddsen, Sigurdur T.en
dc.contributor.authorSalama, Khaled N.en
dc.date.accessioned2016-07-11T09:45:36Z-
dc.date.available2016-07-11T09:45:36Z-
dc.date.issued2016-06-27-
dc.identifier.citationA “twisted” microfluidic mixer suitable for a wide range of flow rate applications 2016, 10 (3):034120 Biomicrofluidicsen
dc.identifier.issn1932-1058-
dc.identifier.doi10.1063/1.4954812-
dc.identifier.urihttp://hdl.handle.net/10754/615927-
dc.description.abstractThis paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.en
dc.description.sponsorshipThe authors would like to thank David Conchoso and Armando Arpys Arevalo Carreno for providing insights on fluid dynamics and the simulation environment. Shilpa Sivashankar designed and administered the experiments, collected and interpreted the data, and wrote the manuscript. Sumeyra Agambayev performed the experiments and carried out calculations. Yousof Mashraei simulated the mixer design and analyzed the simulation results. Sigurdur Thoroddsen designed, and Erqiang Li performed some of the experiments to observe the type of flow within the micro channels. Khaled Nabil Salama supervised the research, provided conceptual advice on the experiments conducted and detail review of the manuscript.en
dc.language.isoenen
dc.publisherAIP Publishingen
dc.relation.urlhttp://scitation.aip.org/content/aip/journal/bmf/10/3/10.1063/1.4954812en
dc.rightsArchived with thanks to Biomicrofluidicsen
dc.titleA “twisted” microfluidic mixer suitable for a wide range of flow rate applicationsen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Science and Engineering (CEMSE) Divisionen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalBiomicrofluidicsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorSivashankar, Shilpaen
kaust.authorAgambayev, Sumeyraen
kaust.authorMashraei, Yousofen
kaust.authorLi, Erqiangen
kaust.authorThoroddsen, Sigurdur T.en
kaust.authorSalama, Khaled N.en
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