Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery

Handle URI:
http://hdl.handle.net/10754/615926
Title:
Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery
Authors:
Patil, Sachin ( 0000-0003-4952-3120 ) ; Moosa, Basem ( 0000-0002-2350-4100 ) ; Alsaiari, Shahad; Alamoudi, Kholod; Alshamsan, Aws; Almailk, Abdulaziz; Adil, Karim; Eddaoudi, Mohamed ( 0000-0003-1916-9837 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light responsive nanostructures.Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible light irradiation leading up to 90% of gene silencing in live cells.
KAUST Department:
Smart Hybrid Materials (SHMs) lab; Functional Materials Design, Discovery and Development (FMD3)
Citation:
Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery 2016 Chemistry - A European Journal
Publisher:
Wiley-Blackwell
Journal:
Chemistry - A European Journal
Issue Date:
29-Jun-2016
DOI:
10.1002/chem.201601442
Type:
Article
ISSN:
09476539
Is Supplemented By:
Patil, S. P., Moosa, B. A., Alsaiari, S., Alamoudi, K., Alshamsan, A., AlMalik, A., … Khashab, N. M. (2016). CCDC 1442746: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccdc.csd.cc1kf96h; DOI:10.5517/ccdc.csd.cc1kf96h; HANDLE:http://hdl.handle.net/10754/624553
Additional Links:
http://doi.wiley.com/10.1002/chem.201601442
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPatil, Sachinen
dc.contributor.authorMoosa, Basemen
dc.contributor.authorAlsaiari, Shahaden
dc.contributor.authorAlamoudi, Kholoden
dc.contributor.authorAlshamsan, Awsen
dc.contributor.authorAlmailk, Abdulazizen
dc.contributor.authorAdil, Karimen
dc.contributor.authorEddaoudi, Mohameden
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2016-07-11T09:41:05Z-
dc.date.available2016-07-11T09:41:05Z-
dc.date.issued2016-06-29-
dc.identifier.citationSupramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery 2016 Chemistry - A European Journalen
dc.identifier.issn09476539-
dc.identifier.doi10.1002/chem.201601442-
dc.identifier.urihttp://hdl.handle.net/10754/615926-
dc.description.abstractSupramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light responsive nanostructures.Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible light irradiation leading up to 90% of gene silencing in live cells.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://doi.wiley.com/10.1002/chem.201601442en
dc.rightsThis is the peer reviewed version of the following article: Patil, S., Moosa, B., Alsaiari, S., Alamoudi, K., Alshamsan, A., Almailk, A., Adil, K., Eddaoudi, M. and Khashab, N. (2016), Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery. Chem. Eur. J.. Accepted Author Manuscript., which has been published in final form at http://doi.wiley.com/10.1002/chem.201601442. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.en
dc.titleSupramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Deliveryen
dc.typeArticleen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentFunctional Materials Design, Discovery and Development (FMD3)en
dc.identifier.journalChemistry - A European Journalen
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Pharmaceutics, College of Pharmacy and King Abdullah Institute of Nanotechnology, King Saud University, KSAen
dc.contributor.institutionCenter of Excellence in Nanomedicine, King Abdulaziz City for Science and Technology (KACST), Riyadh, KSAen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorKhashab, Niveen M.en
dc.relation.isSupplementedByPatil, S. P., Moosa, B. A., Alsaiari, S., Alamoudi, K., Alshamsan, A., AlMalik, A., … Khashab, N. M. (2016). CCDC 1442746: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccdc.csd.cc1kf96hen
dc.relation.isSupplementedByDOI:10.5517/ccdc.csd.cc1kf96hen
dc.relation.isSupplementedByHANDLE:http://hdl.handle.net/10754/624553en
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