Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery

Handle URI:
http://hdl.handle.net/10754/614899
Title:
Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery
Authors:
Yassine, Omar ( 0000-0002-0117-8017 ) ; Li, Erqiang ( 0000-0002-5003-0756 ) ; Alfadhel, Ahmed ( 0000-0003-3244-0644 ) ; Zaher, A.; Kavaldzhiev, Mincho ( 0000-0003-1335-6797 ) ; Thoroddsen, Sigurdur T. ( 0000-0001-6997-4311 ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
Responsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500  µ m at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method.
KAUST Department:
Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division; Physical Sciences and Engineering (PSE) Division
Citation:
Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery 2016, 2016:1 International Journal of Polymer Science
Publisher:
Hindawi Publishing Corporation
Journal:
International Journal of Polymer Science
Issue Date:
1-Jan-2016
DOI:
10.1155/2016/1219469
Type:
Article
ISSN:
1687-9422; 1687-9430
Sponsors:
Research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST). E. Q. Li is grateful for a SABIC Postdoctoral Fellowship.
Additional Links:
http://www.hindawi.com/journals/ijps/2016/1219469/
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorYassine, Omaren
dc.contributor.authorLi, Erqiangen
dc.contributor.authorAlfadhel, Ahmeden
dc.contributor.authorZaher, A.en
dc.contributor.authorKavaldzhiev, Minchoen
dc.contributor.authorThoroddsen, Sigurdur T.en
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2016-06-28T11:22:56Z-
dc.date.available2016-06-28T11:22:56Z-
dc.date.issued2016-01-01-
dc.identifier.citationMagnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery 2016, 2016:1 International Journal of Polymer Scienceen
dc.identifier.issn1687-9422-
dc.identifier.issn1687-9430-
dc.identifier.doi10.1155/2016/1219469-
dc.identifier.urihttp://hdl.handle.net/10754/614899-
dc.description.abstractResponsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500  µ m at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method.en
dc.description.sponsorshipResearch reported in this publication was supported by King Abdullah University of Science and Technology (KAUST). E. Q. Li is grateful for a SABIC Postdoctoral Fellowship.en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.relation.urlhttp://www.hindawi.com/journals/ijps/2016/1219469/en
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/en
dc.titleMagnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Deliveryen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Science and Engineering (CEMSE) Divisionen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalInternational Journal of Polymer Scienceen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionSchool of Engineering, University of British Columbia, 3333 University Way, Kelowna, BC, Canada V1V 1V7en
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorYassine, Omaren
kaust.authorLi, Erqiangen
kaust.authorAlfadhel, Ahmeden
kaust.authorKavaldzhiev, Minchoen
kaust.authorThoroddsen, Sigurdur T.en
kaust.authorKosel, Jürgenen
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