Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications

Handle URI:
http://hdl.handle.net/10754/614805
Title:
Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications
Authors:
Yassine, Omar ( 0000-0002-0117-8017 ) ; Zaher, Amir ( 0000-0002-5521-5389 ) ; Li, Erqiang ( 0000-0002-5003-0756 ) ; Alfadhel, Ahmed ( 0000-0003-3244-0644 ) ; Perez, Jose E. ( 0000-0002-2206-0034 ) ; Kavaldzhiev, Mincho ( 0000-0003-1335-6797 ) ; Contreras, Maria F. ( 0000-0001-6239-5325 ) ; Thoroddsen, Sigurdur T. ( 0000-0001-6997-4311 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
Highly efficient magnetic release from nanocomposite microparticles is shown, which are made of Poly (N-isopropylacrylamide) hydrogel with embedded iron nanowires. A simple microfluidic technique was adopted to fabricate the microparticles with a high control of the nanowire concentration and in a relatively short time compared to chemical synthesis methods. The thermoresponsive microparticles were used for the remotely triggered release of Rhodamine (B). With a magnetic field of only 1 mT and 20 kHz a drug release of 6.5% and 70% was achieved in the continuous and pulsatile modes, respectively. Those release values are similar to the ones commonly obtained using superparamagnetic beads but accomplished with a magnetic field of five orders of magnitude lower power. The high efficiency is a result of the high remanent magnetization of the nanowires, which produce a large torque when exposed to a magnetic field. This causes the nanowires to vibrate, resulting in friction losses and heating. For comparison, microparticles with superparamagnetic beads were also fabricated and tested; while those worked at 73 mT and 600 kHz, no release was observed at the low field conditions. Cytotoxicity assays showed similar and high cell viability for microparticles with nanowires and beads.
KAUST Department:
Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division; Physical Sciences and Engineering (PSE) Division; Biological and Environmental Sciences and Engineering (BESE) Division; Smart Hybrid Materials (SHMs) lab; Advanced Membranes and Porous Materials Center (AMPMC)
Citation:
Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications 2016, 6:28539 Scientific Reports
Publisher:
Springer Nature
Journal:
Scientific Reports
Issue Date:
23-Jun-2016
DOI:
10.1038/srep28539
Type:
Article
ISSN:
2045-2322
Sponsors:
Research reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). EQL is grateful for a SABIC Postdoctoral Fellowship.
Additional Links:
http://www.nature.com/articles/srep28539
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorYassine, Omaren
dc.contributor.authorZaher, Amiren
dc.contributor.authorLi, Erqiangen
dc.contributor.authorAlfadhel, Ahmeden
dc.contributor.authorPerez, Jose E.en
dc.contributor.authorKavaldzhiev, Minchoen
dc.contributor.authorContreras, Maria F.en
dc.contributor.authorThoroddsen, Sigurdur T.en
dc.contributor.authorKhashab, Niveen M.en
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2016-06-27T10:45:08Z-
dc.date.available2016-06-27T10:45:08Z-
dc.date.issued2016-06-23-
dc.identifier.citationHighly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications 2016, 6:28539 Scientific Reportsen
dc.identifier.issn2045-2322-
dc.identifier.doi10.1038/srep28539-
dc.identifier.urihttp://hdl.handle.net/10754/614805-
dc.description.abstractHighly efficient magnetic release from nanocomposite microparticles is shown, which are made of Poly (N-isopropylacrylamide) hydrogel with embedded iron nanowires. A simple microfluidic technique was adopted to fabricate the microparticles with a high control of the nanowire concentration and in a relatively short time compared to chemical synthesis methods. The thermoresponsive microparticles were used for the remotely triggered release of Rhodamine (B). With a magnetic field of only 1 mT and 20 kHz a drug release of 6.5% and 70% was achieved in the continuous and pulsatile modes, respectively. Those release values are similar to the ones commonly obtained using superparamagnetic beads but accomplished with a magnetic field of five orders of magnitude lower power. The high efficiency is a result of the high remanent magnetization of the nanowires, which produce a large torque when exposed to a magnetic field. This causes the nanowires to vibrate, resulting in friction losses and heating. For comparison, microparticles with superparamagnetic beads were also fabricated and tested; while those worked at 73 mT and 600 kHz, no release was observed at the low field conditions. Cytotoxicity assays showed similar and high cell viability for microparticles with nanowires and beads.en
dc.description.sponsorshipResearch reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). EQL is grateful for a SABIC Postdoctoral Fellowship.en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.urlhttp://www.nature.com/articles/srep28539en
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.titleHighly Efficient Thermoresponsive Nanocomposite for Controlled Release Applicationsen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Science and Engineering (CEMSE) Divisionen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAdvanced Membranes and Porous Materials Center (AMPMC)en
dc.identifier.journalScientific Reportsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionSchool of Engineering, University of British Columbia, 3333 University Way, Kelowna, BC, V1V 1V7, Canadaen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorYassine, Omaren
kaust.authorLi, Erqiangen
kaust.authorAlfadhel, Ahmeden
kaust.authorPerez, Jose E.en
kaust.authorKavaldzhiev, Minchoen
kaust.authorContreras, Maria F.en
kaust.authorThoroddsen, Sigurdur T.en
kaust.authorKhashab, Niveen M.en
kaust.authorKosel, Jürgenen
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