Homogeneous Biosensing Based on Magnetic Particle Labels

Handle URI:
http://hdl.handle.net/10754/614419
Title:
Homogeneous Biosensing Based on Magnetic Particle Labels
Authors:
Schrittwieser, Stefan; Pelaz, Beatriz; Parak, Wolfgang; Lentijo-Mozo, Sergio; Soulantica, Katerina; Dieckhoff, Jan; Ludwig, Frank; Guenther, Annegret; Tschöpe, Andreas ( 0000-0003-1717-849X ) ; Schotter, Joerg
Abstract:
The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation.
KAUST Department:
NABLA Lab; Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Homogeneous Biosensing Based on Magnetic Particle Labels 2016, 16 (6):828 Sensors
Publisher:
MDPI AG
Journal:
Sensors
Issue Date:
6-Jun-2016
DOI:
10.3390/s16060828
Type:
Article
ISSN:
1424-8220
Sponsors:
Parts of this work were supported by the European Commission (project FutureNanoNeeds to WJP) and by the European Commission FP7 NAMDIATREAM project (EU NMP4-LA-2010-246479).
Additional Links:
http://www.mdpi.com/1424-8220/16/6/828
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSchrittwieser, Stefanen
dc.contributor.authorPelaz, Beatrizen
dc.contributor.authorParak, Wolfgangen
dc.contributor.authorLentijo-Mozo, Sergioen
dc.contributor.authorSoulantica, Katerinaen
dc.contributor.authorDieckhoff, Janen
dc.contributor.authorLudwig, Franken
dc.contributor.authorGuenther, Annegreten
dc.contributor.authorTschöpe, Andreasen
dc.contributor.authorSchotter, Joergen
dc.date.accessioned2016-06-23T11:05:28Z-
dc.date.available2016-06-23T11:05:28Z-
dc.date.issued2016-06-06-
dc.identifier.citationHomogeneous Biosensing Based on Magnetic Particle Labels 2016, 16 (6):828 Sensorsen
dc.identifier.issn1424-8220-
dc.identifier.doi10.3390/s16060828-
dc.identifier.urihttp://hdl.handle.net/10754/614419-
dc.description.abstractThe growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation.en
dc.description.sponsorshipParts of this work were supported by the European Commission (project FutureNanoNeeds to WJP) and by the European Commission FP7 NAMDIATREAM project (EU NMP4-LA-2010-246479).en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.urlhttp://www.mdpi.com/1424-8220/16/6/828en
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectbiosensoren
dc.subjectmagnetic nanoparticleen
dc.subjecthomogeneous assayen
dc.subjectmagnetorelaxationen
dc.subjectAC susceptibilityen
dc.subjectNMRen
dc.subjectmagnetic relaxation switchen
dc.subjectasynchronous magnetorotationen
dc.subjectmagneto-opticsen
dc.subjectnanoroden
dc.titleHomogeneous Biosensing Based on Magnetic Particle Labelsen
dc.typeArticleen
dc.contributor.departmentNABLA Laben
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalSensorsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionMolecular Diagnostics, AIT Austrian Institute of Technology, Vienna1220, Austriaen
dc.contributor.institutionFachbereich Physik, Philipps-Universität Marburg, Marburg 35037, Germanyen
dc.contributor.institutionLaboratoire de Physique et Chimie des Nano-objets (LPCNO), Université de Toulouse, INSA, UPS, CNRS, Toulouse 31077, Franceen
dc.contributor.institutionInstitute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, Braunschweig 38106, Germanyen
dc.contributor.institutionExperimentalphysik, Universität des Saarlandes, Saarbrücken 66123, Germanyen
dc.contributor.institutionDiagnostic and Interventional Radiology Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germanyen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorLentijo-Mozo, Sergioen
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