Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Handle URI:
http://hdl.handle.net/10754/612998
Title:
Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
Authors:
Croissant, Jonas; Fatieiev, Yevhen; Julfakyan, Khachatur ( 0000-0003-2482-0911 ) ; Lu, Jie; Emwas, Abdelhamid; Anjum, Dalaver; Omar, Haneen; Tamanoi, Fuyuhiko; Zink, Jeffrey; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
KAUST Department:
Smart Hybrid Materials (SHMs) lab; Advanced Membranes and Porous Materials Center (AMPMC); Imaging and Characterization Core Lab
Citation:
Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells 2016 Chemistry - A European Journal
Publisher:
Wiley-Blackwell
Journal:
Chemistry - A European Journal
Issue Date:
3-Jun-2016
DOI:
10.1002/chem.201601714
Type:
Article
ISSN:
09476539
Sponsors:
The authors gratefully acknowledge King Abdullah University of Science and Technology and the University of California, Los Angeles for the support of this work.
Additional Links:
http://doi.wiley.com/10.1002/chem.201601714
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCroissant, Jonasen
dc.contributor.authorFatieiev, Yevhenen
dc.contributor.authorJulfakyan, Khachaturen
dc.contributor.authorLu, Jieen
dc.contributor.authorEmwas, Abdelhamiden
dc.contributor.authorAnjum, Dalaveren
dc.contributor.authorOmar, Haneenen
dc.contributor.authorTamanoi, Fuyuhikoen
dc.contributor.authorZink, Jeffreyen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2016-06-14T08:04:08Z-
dc.date.available2016-06-14T08:04:08Z-
dc.date.issued2016-06-03-
dc.identifier.citationBiodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells 2016 Chemistry - A European Journalen
dc.identifier.issn09476539-
dc.identifier.doi10.1002/chem.201601714-
dc.identifier.urihttp://hdl.handle.net/10754/612998-
dc.description.abstractWe describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.en
dc.description.sponsorshipThe authors gratefully acknowledge King Abdullah University of Science and Technology and the University of California, Los Angeles for the support of this work.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://doi.wiley.com/10.1002/chem.201601714en
dc.rightsThis is the peer reviewed version of the following article: Croissant, J., Fatieiev, Y., Julfakyan, K., Lu, J., Emwas, A., Anjum, D., Omar, H., Tamanoi, F., Zink, J. and Khashab, N. (2016), Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells. Chem. Eur. J., which has been published in final form at http://doi.wiley.com/10.1002/chem.201601714. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.en
dc.titleBiodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cellsen
dc.typeArticleen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAdvanced Membranes and Porous Materials Center (AMPMC)en
dc.contributor.departmentImaging and Characterization Core Laben
dc.identifier.journalChemistry - A European Journalen
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, Unites Statesen
dc.contributor.institutionDepartment of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.en
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorKhashab, Niveen M.en
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