Membrane manufacture for peptide separations

Handle URI:
http://hdl.handle.net/10754/612970
Title:
Membrane manufacture for peptide separations
Authors:
Kim, Dooli ( 0000-0003-4137-0350 ) ; Salazar Moya, Octavio; Nunes, Suzana Pereira ( 0000-0002-3669-138X )
Abstract:
Nanostructured polymeric membranes are key tools in biomedical applications such as hemodialysis, protein separations, in the food industry, and drinking water supply from seawater. Despite of the success in different separation processes, membrane manufacture itself is at risk, since the most used solvents are about to be banned in many countries due to environmental and health issues. We propose for the first time the preparation of polyethersulfone membranes based on dissolution in the ionic liquid 1-ethyl-3-methylimidazolium dimethylphosphate ([EMIM]DEP). We obtained a series of membranes tailored for separation of solutes with molecular weight of 30, 5, 1.3, and 1.25 kg mol-1 with respective water permeances of 140, 65, 30 and 20 Lm-2h-1bar-1. We demonstrate their superior efficiency in the separation of complex mixtures of peptides with molecular weights in the range of 800 to 3500 gmol-1. Furthermore, the thermodynamics and kinetics of phase separation leading to the pore formation in the membranes were investigated. The rheology of the solutions and the morphology of the prepared membranes were examed and compared to those of polyethersulfone in organic solvents currently used for membrane manufacture.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Membrane manufacture for peptide separations 2016 Green Chem.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Green Chem.
Issue Date:
7-Jun-2016
DOI:
10.1039/C6GC01259K
Type:
Article
ISSN:
1463-9262; 1463-9270
Sponsors:
The research reported in this publication was sponsored by King Abdullah University of Science and Technology (KAUST).
Additional Links:
http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01259K
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorKim, Doolien
dc.contributor.authorSalazar Moya, Octavioen
dc.contributor.authorNunes, Suzana Pereiraen
dc.date.accessioned2016-06-14T08:57:53Z-
dc.date.available2016-06-14T08:57:53Z-
dc.date.issued2016-06-07-
dc.identifier.citationMembrane manufacture for peptide separations 2016 Green Chem.en
dc.identifier.issn1463-9262-
dc.identifier.issn1463-9270-
dc.identifier.doi10.1039/C6GC01259K-
dc.identifier.urihttp://hdl.handle.net/10754/612970-
dc.description.abstractNanostructured polymeric membranes are key tools in biomedical applications such as hemodialysis, protein separations, in the food industry, and drinking water supply from seawater. Despite of the success in different separation processes, membrane manufacture itself is at risk, since the most used solvents are about to be banned in many countries due to environmental and health issues. We propose for the first time the preparation of polyethersulfone membranes based on dissolution in the ionic liquid 1-ethyl-3-methylimidazolium dimethylphosphate ([EMIM]DEP). We obtained a series of membranes tailored for separation of solutes with molecular weight of 30, 5, 1.3, and 1.25 kg mol-1 with respective water permeances of 140, 65, 30 and 20 Lm-2h-1bar-1. We demonstrate their superior efficiency in the separation of complex mixtures of peptides with molecular weights in the range of 800 to 3500 gmol-1. Furthermore, the thermodynamics and kinetics of phase separation leading to the pore formation in the membranes were investigated. The rheology of the solutions and the morphology of the prepared membranes were examed and compared to those of polyethersulfone in organic solvents currently used for membrane manufacture.en
dc.description.sponsorshipThe research reported in this publication was sponsored by King Abdullah University of Science and Technology (KAUST).en
dc.language.isoenen
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01259Ken
dc.rightsArchived with thanks to Green Chem.en
dc.titleMembrane manufacture for peptide separationsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalGreen Chem.en
dc.eprint.versionPost-printen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorKim, Doolien
kaust.authorSalazar Moya, Octavioen
kaust.authorNunes, Suzana Pereiraen
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