Characterization of piRNAs across postnatal development in mouse brain

Handle URI:
http://hdl.handle.net/10754/607207
Title:
Characterization of piRNAs across postnatal development in mouse brain
Authors:
Ghosheh, Yanal ( 0000-0002-3733-2098 ) ; Seridi, Loqmane ( 0000-0001-7028-3024 ) ; Ryu, Tae Woo; Takahashi, Hazuki; Orlando, Valerio ( 0000-0002-4906-8511 ) ; Carninci, Piero; Ravasi, Timothy ( 0000-0002-9950-465X )
Abstract:
PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
KAUST Department:
Applied Mathematics and Computational Science Program; KAUST Environmental Epigenetics Research Program (KEEP); Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Characterization of piRNAs across postnatal development in mouse brain 2016, 6:25039 Scientific Reports
Publisher:
Nature Publishing Group
Journal:
Scientific Reports
Issue Date:
26-Apr-2016
DOI:
10.1038/srep25039
Type:
Article
ISSN:
2045-2322
Sponsors:
Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Additional Links:
http://www.nature.com/articles/srep25039
Appears in Collections:
Articles; Applied Mathematics and Computational Science Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGhosheh, Yanalen
dc.contributor.authorSeridi, Loqmaneen
dc.contributor.authorRyu, Tae Wooen
dc.contributor.authorTakahashi, Hazukien
dc.contributor.authorOrlando, Valerioen
dc.contributor.authorCarninci, Pieroen
dc.contributor.authorRavasi, Timothyen
dc.date.accessioned2016-04-27T12:01:01Zen
dc.date.available2016-04-27T12:01:01Zen
dc.date.issued2016-04-26en
dc.identifier.citationCharacterization of piRNAs across postnatal development in mouse brain 2016, 6:25039 Scientific Reportsen
dc.identifier.issn2045-2322en
dc.identifier.doi10.1038/srep25039en
dc.identifier.urihttp://hdl.handle.net/10754/607207en
dc.description.abstractPIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.en
dc.description.sponsorshipY.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/articles/srep25039en
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.titleCharacterization of piRNAs across postnatal development in mouse brainen
dc.typeArticleen
dc.contributor.departmentApplied Mathematics and Computational Science Programen
dc.contributor.departmentKAUST Environmental Epigenetics Research Program (KEEP)en
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalScientific Reportsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionRIKEN Center for Life Science Technologies, Division of Genomic Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japanen
dc.contributor.institutionDepartment of Medicine, Division of Genetic, University of California, San Diego. 9500 Gilman Drive La Jolla, California 92093-0688, USAen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorGhosheh, Yanalen
kaust.authorSeridi, Loqmaneen
kaust.authorRyu, Tae Wooen
kaust.authorOrlando, Valerioen
kaust.authorRavasi, Timothyen
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