Multiscale modification of the conductive PEDOT:PSS polymer for the analysis of biological mixtures in a super-hydrophobic drop

Handle URI:
http://hdl.handle.net/10754/602295
Title:
Multiscale modification of the conductive PEDOT:PSS polymer for the analysis of biological mixtures in a super-hydrophobic drop
Authors:
Coppedè, Nicola; Ferrara, Lorenzo ( 0000-0002-6157-3369 ) ; Bifulco, Paolo; Villani, Marco; Iannotta, Salvatore; Zappettini, Andrea; Cesarelli, Mario; Di Fabrizio, Enzo M. ( 0000-0001-5886-4678 ) ; Gentile, Francesco
Abstract:
Conducting polymers are materials displaying high electrical conductivity, easy of fabrication, flexibility and biocompatibility, for this, they are routinely employed in organic electronics, printed electronics, and bioelectronics. Organic electrochemical transistors (OECTs) are a second generation of organic thin transistors, in which the insulator layer is an electrolyte medium and the conductive polymer is electrochemically active. OECT devices have been demonstrated in chemical and biological sensing: while accurate in determining the size of individual ions in solution, similar devices break down if challenged with complex mixtures. Here, we combine a conductive PEODOT:PSS polymer with a super-hydrophobic scheme to obtain a family of advanced devices, in which the ability to manipulate a biological solution couples to a precise texture of the substrate (which incorporates five micro-electrodes in a line, and each is a site specific measurement point), and this permits to realize time and space resolved analysis of a solution. While the competition between convection and diffusion in a super-hydrophobic drop operates the separation of different species based on their size and charge, the described device delivers the ability to register a similar difference. In the following, we demonstrate the device in the sensing of a solution in which CTAB and adrenaline are separated with good sensitivity, selectivity and reliability.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
Multiscale modification of the conductive PEDOT:PSS polymer for the analysis of biological mixtures in a super-hydrophobic drop 2016 Microelectronic Engineering
Publisher:
Elsevier BV
Journal:
Microelectronic Engineering
Issue Date:
18-Mar-2016
DOI:
10.1016/j.mee.2016.03.033
Type:
Article
ISSN:
01679317
Sponsors:
This work has been partially funded from the Italian Minister of Health (Project no. GR-2010-2320665). NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support.
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0167931716301447
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorCoppedè, Nicolaen
dc.contributor.authorFerrara, Lorenzoen
dc.contributor.authorBifulco, Paoloen
dc.contributor.authorVillani, Marcoen
dc.contributor.authorIannotta, Salvatoreen
dc.contributor.authorZappettini, Andreaen
dc.contributor.authorCesarelli, Marioen
dc.contributor.authorDi Fabrizio, Enzo M.en
dc.contributor.authorGentile, Francescoen
dc.date.accessioned2016-03-20T13:56:32Zen
dc.date.available2016-03-20T13:56:32Zen
dc.date.issued2016-03-18en
dc.identifier.citationMultiscale modification of the conductive PEDOT:PSS polymer for the analysis of biological mixtures in a super-hydrophobic drop 2016 Microelectronic Engineeringen
dc.identifier.issn01679317en
dc.identifier.doi10.1016/j.mee.2016.03.033en
dc.identifier.urihttp://hdl.handle.net/10754/602295en
dc.description.abstractConducting polymers are materials displaying high electrical conductivity, easy of fabrication, flexibility and biocompatibility, for this, they are routinely employed in organic electronics, printed electronics, and bioelectronics. Organic electrochemical transistors (OECTs) are a second generation of organic thin transistors, in which the insulator layer is an electrolyte medium and the conductive polymer is electrochemically active. OECT devices have been demonstrated in chemical and biological sensing: while accurate in determining the size of individual ions in solution, similar devices break down if challenged with complex mixtures. Here, we combine a conductive PEODOT:PSS polymer with a super-hydrophobic scheme to obtain a family of advanced devices, in which the ability to manipulate a biological solution couples to a precise texture of the substrate (which incorporates five micro-electrodes in a line, and each is a site specific measurement point), and this permits to realize time and space resolved analysis of a solution. While the competition between convection and diffusion in a super-hydrophobic drop operates the separation of different species based on their size and charge, the described device delivers the ability to register a similar difference. In the following, we demonstrate the device in the sensing of a solution in which CTAB and adrenaline are separated with good sensitivity, selectivity and reliability.en
dc.description.sponsorshipThis work has been partially funded from the Italian Minister of Health (Project no. GR-2010-2320665). NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support.en
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0167931716301447en
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Microelectronic Engineering. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Microelectronic Engineering, 18 March 2016. DOI: 10.1016/j.mee.2016.03.033en
dc.subjectPEDOT:PSSen
dc.subjectOECTen
dc.subjectSuper-hydrophobic surfacesen
dc.subjectBiological mixturesen
dc.subjectMultiscale textureen
dc.subjectDetectionen
dc.titleMultiscale modification of the conductive PEDOT:PSS polymer for the analysis of biological mixtures in a super-hydrophobic dropen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalMicroelectronic Engineeringen
dc.eprint.versionPost-printen
dc.contributor.institutionIMEM-CNR Parco Area delle Scienze 37/A, 43124 Parma, Italyen
dc.contributor.institutionIstituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italyen
dc.contributor.institutionDepartment of Electrical Engineering and Information Technology, University Federico II, Naples, Italyen
dc.contributor.institutionDepartment of Experimental and Clinical Medicine, University of Magna Graecia, 88100 Catanzaro, Italyen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorDi Fabrizio, Enzo M.en
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