Handle URI:
http://hdl.handle.net/10754/601415
Title:
The Genomic Code: Genome Evolution and Potential Applications
Authors:
Bernardi, Giorgio
Abstract:
The genome of metazoans is organized according to a genomic code which comprises three laws: 1) Compositional correlations hold between contiguous coding and non-coding sequences, as well as among the three codon positions of protein-coding genes; these correlations are the consequence of the fact that the genomes under consideration consist of fairly homogeneous, long (≥200Kb) sequences, the isochores; 2) Although isochores are defined on the basis of purely compositional properties, GC levels of isochores are correlated with all tested structural and functional properties of the genome; 3) GC levels of isochores are correlated with chromosome architecture from interphase to metaphase; in the case of interphase the correlation concerns isochores and the three-dimensional “topological associated domains” (TADs); in the case of mitotic chromosomes, the correlation concerns isochores and chromosomal bands. Finally, the genomic code is the fourth and last pillar of molecular biology, the first three pillars being 1) the double helix structure of DNA; 2) the regulation of gene expression in prokaryotes; and 3) the genetic code.
Conference/Event name:
KAUST Research Conference on Computational and Experimental Interfaces of Big Data and Biotechnology
Issue Date:
25-Jan-2016
Type:
Presentation
Appears in Collections:
KAUST Research Conference on Computational and Experimental Interfaces of Big Data and Biotechnology, January 2016

Full metadata record

DC FieldValue Language
dc.contributor.authorBernardi, Giorgioen
dc.date.accessioned2016-03-16T12:53:37Zen
dc.date.available2016-03-16T12:53:37Zen
dc.date.issued2016-01-25en
dc.identifier.urihttp://hdl.handle.net/10754/601415en
dc.description.abstractThe genome of metazoans is organized according to a genomic code which comprises three laws: 1) Compositional correlations hold between contiguous coding and non-coding sequences, as well as among the three codon positions of protein-coding genes; these correlations are the consequence of the fact that the genomes under consideration consist of fairly homogeneous, long (≥200Kb) sequences, the isochores; 2) Although isochores are defined on the basis of purely compositional properties, GC levels of isochores are correlated with all tested structural and functional properties of the genome; 3) GC levels of isochores are correlated with chromosome architecture from interphase to metaphase; in the case of interphase the correlation concerns isochores and the three-dimensional “topological associated domains” (TADs); in the case of mitotic chromosomes, the correlation concerns isochores and chromosomal bands. Finally, the genomic code is the fourth and last pillar of molecular biology, the first three pillars being 1) the double helix structure of DNA; 2) the regulation of gene expression in prokaryotes; and 3) the genetic code.en
dc.titleThe Genomic Code: Genome Evolution and Potential Applicationsen
dc.typePresentationen
dc.conference.dateJanuary 25-27, 2016en
dc.conference.nameKAUST Research Conference on Computational and Experimental Interfaces of Big Data and Biotechnologyen
dc.conference.locationKAUST, Thuwal, Saudi Arabiaen
dc.contributor.institutionUniversita Roma Treen
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.