Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo

Handle URI:
http://hdl.handle.net/10754/600522
Title:
Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo
Authors:
Deng, Lin ( 0000-0001-8954-5610 ) ; Li, Qiujin; Al-Rehili, Safa'a; Omar, Haneen; Almalik, Abdulaziz; Alshamsan, Aws; Zhang, Jianfei; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Premature drug release is a common drawback in stimuli responsive drug delivery systems (DDS) especially if it depends on internal triggers, that are hard to control, or a single external stimulus, that can only have one function. Thus, many DDS systems were reported combining different triggers, however limited success has been established in fine-tuning the release process mainly due to the poor bioavailability and complexity of the reported designs. This paper reports the design of a hybrid microcapsule (h-MC) by a simple layer-by-layer technique comprising polysaccharides (Alg, Chi, HA), iron oxide, and graphene oxide. Electrostatic assembly of the oppositely charged polysaccharides and graphene sheets provided a robust structure to load drugs through pH control. The polysaccharides component ensured high biocompatibility, bioavailability, and tumor cells targeting. Magnetic field and near infrared laser triggerable Fe3O4@GO component provided dual high energy and high penetration hyperthermia therapy. On-demand drug release from h-MC can be achieved by synchronizing these external triggers, making it highly controllable. The synergistic effect of hyperthermia and chemotherapy was successfully confirmed in vitro and in vivo.
KAUST Department:
Smart Hybrid Materials (SHMs) lab; Advanced Membranes and Porous Materials Research Center
Citation:
Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo 2016 ACS Applied Materials & Interfaces
Publisher:
American Chemical Society (ACS)
Journal:
ACS Applied Materials & Interfaces
Issue Date:
25-Feb-2016
DOI:
10.1021/acsami.6b00322
Type:
Article
ISSN:
1944-8244; 1944-8252
Sponsors:
This work was supported by King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, and the Natural Science Foundation of Tianjin, China (15JCYBJC18000).
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/acsami.6b00322
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorDeng, Linen
dc.contributor.authorLi, Qiujinen
dc.contributor.authorAl-Rehili, Safa'aen
dc.contributor.authorOmar, Haneenen
dc.contributor.authorAlmalik, Abdulazizen
dc.contributor.authorAlshamsan, Awsen
dc.contributor.authorZhang, Jianfeien
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2016-03-03T12:22:18Zen
dc.date.available2016-03-03T12:22:18Zen
dc.date.issued2016-02-25en
dc.identifier.citationHybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo 2016 ACS Applied Materials & Interfacesen
dc.identifier.issn1944-8244en
dc.identifier.issn1944-8252en
dc.identifier.doi10.1021/acsami.6b00322en
dc.identifier.urihttp://hdl.handle.net/10754/600522en
dc.description.abstractPremature drug release is a common drawback in stimuli responsive drug delivery systems (DDS) especially if it depends on internal triggers, that are hard to control, or a single external stimulus, that can only have one function. Thus, many DDS systems were reported combining different triggers, however limited success has been established in fine-tuning the release process mainly due to the poor bioavailability and complexity of the reported designs. This paper reports the design of a hybrid microcapsule (h-MC) by a simple layer-by-layer technique comprising polysaccharides (Alg, Chi, HA), iron oxide, and graphene oxide. Electrostatic assembly of the oppositely charged polysaccharides and graphene sheets provided a robust structure to load drugs through pH control. The polysaccharides component ensured high biocompatibility, bioavailability, and tumor cells targeting. Magnetic field and near infrared laser triggerable Fe3O4@GO component provided dual high energy and high penetration hyperthermia therapy. On-demand drug release from h-MC can be achieved by synchronizing these external triggers, making it highly controllable. The synergistic effect of hyperthermia and chemotherapy was successfully confirmed in vitro and in vivo.en
dc.description.sponsorshipThis work was supported by King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, and the Natural Science Foundation of Tianjin, China (15JCYBJC18000).en
dc.language.isoenen
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.6b00322en
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.6b00322.en
dc.titleHybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivoen
dc.typeArticleen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.identifier.journalACS Applied Materials & Interfacesen
dc.eprint.versionPost-printen
dc.contributor.institutionSchool of Textiles, Tianjin Polytechnic University; Key Laboratory of Advanced Textile Composites (Tianjin Polytechnic University), Ministry of Education, Tianjin 300387, Chinaen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
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