Probing Chromatin-modifying Enzymes with Chemical Tools

Handle URI:
http://hdl.handle.net/10754/600475
Title:
Probing Chromatin-modifying Enzymes with Chemical Tools
Authors:
Fischle, Wolfgang ( 0000-0002-2335-8932 ) ; Schwarzer, Dirk
Abstract:
Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.
KAUST Department:
Environmental Epigenetics Program
Citation:
Probing Chromatin-modifying Enzymes with Chemical Tools 2016 ACS Chemical Biology
Publisher:
American Chemical Society (ACS)
Journal:
ACS Chemical Biology
Issue Date:
4-Feb-2016
DOI:
10.1021/acschembio.5b01023
Type:
Article
ISSN:
1554-8929; 1554-8937
Sponsors:
This work was funded by the priority program SPP1623 of the Deutsche Forschungsgemeinschaft (W.F. and D.S., Grants: FL 1513/3-1 and SCHW 1163/4-1) as well as intramural programs of the King Abdullah University of Science and Technology (KAUST) and the Max Planck Society (W.F.).
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/acschembio.5b01023
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorFischle, Wolfgangen
dc.contributor.authorSchwarzer, Dirken
dc.date.accessioned2016-03-02T06:38:55Zen
dc.date.available2016-03-02T06:38:55Zen
dc.date.issued2016-02-04en
dc.identifier.citationProbing Chromatin-modifying Enzymes with Chemical Tools 2016 ACS Chemical Biologyen
dc.identifier.issn1554-8929en
dc.identifier.issn1554-8937en
dc.identifier.doi10.1021/acschembio.5b01023en
dc.identifier.urihttp://hdl.handle.net/10754/600475en
dc.description.abstractChromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.en
dc.description.sponsorshipThis work was funded by the priority program SPP1623 of the Deutsche Forschungsgemeinschaft (W.F. and D.S., Grants: FL 1513/3-1 and SCHW 1163/4-1) as well as intramural programs of the King Abdullah University of Science and Technology (KAUST) and the Max Planck Society (W.F.).en
dc.language.isoenen
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acschembio.5b01023en
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acschembio.5b01023.en
dc.titleProbing Chromatin-modifying Enzymes with Chemical Toolsen
dc.typeArticleen
dc.contributor.departmentEnvironmental Epigenetics Programen
dc.identifier.journalACS Chemical Biologyen
dc.eprint.versionPost-printen
dc.contributor.institutionMax Planck Institute for Biophysical Chemistry, Laboratory of Chromatin Biochemistry, Am Fassberg 11, 37077 Göttingen, Germanyen
dc.contributor.institutionInterfaculty Institute of Biochemistry (IFIB), University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germanyen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorFischle, Wolfgangen
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